Diterpenoids as potential anti-inflammatory agents from Ajuga pantantha.

Ajuga / chemistry Animals Anti-Inflammatory Agents / chemistry Disease Models, Animal Diterpenes, Clerodane / pharmacology Molecular Docking Simulation / methods Molecular Structure Phytochemicals Zebrafish
Ajuga pantantha Diterpenoids Inflammation Molecular docking Nitric oxide inhibitory effects Zebrafish model

Journal

Bioorganic chemistry
ISSN: 1090-2120
Titre abrégé: Bioorg Chem
Pays: United States
ID NLM: 1303703

Informations de publication

Date de publication:
08 2020
Historique:
received: 04 12 2019
revised: 04 05 2020
accepted: 20 05 2020
pubmed: 9 6 2020
medline: 3 3 2021
entrez: 8 6 2020
Statut: ppublish

Résumé

A phytochemical survey to obtain bioactive natural products from Ajuga pantantha afforded five new neo-clerodane diterpenoids (1-5). The structures were established by analysis of their NMR spectroscopic data, and electronic circular dichroism calculations were applied to define their absolute configurations. Compounds 2 and 5 were found to have the property of inhibiting NO production (IC

Identifiants

DOI: 10.1016/j.bioorg.2020.103966 PMID: 32506016
pubmed: 32506016
pii: S0045-2068(19)32057-7
doi: 10.1016/j.bioorg.2020.103966
pii:
doi:

Substances chimiques

Anti-Inflammatory Agents 0
Diterpenes, Clerodane 0
Phytochemicals 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

103966

Informations de copyright

Copyright © 2020 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interest The authors of the present manuscript have declared that no competing interests exist.

Auteurs

Wenpei Liu (W)

State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, Tianjin Key Laboratory of Molecular Drug Research, and Drug Discovery Center for Infectious Disease, Nankai University, Tianjin 300350, China.

Ziteng Song (Z)

State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, Tianjin Key Laboratory of Molecular Drug Research, and Drug Discovery Center for Infectious Disease, Nankai University, Tianjin 300350, China; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.

Huimei Wang (H)

State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, Tianjin Key Laboratory of Molecular Drug Research, and Drug Discovery Center for Infectious Disease, Nankai University, Tianjin 300350, China.

Xueyuan Yang (X)

State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, Tianjin Key Laboratory of Molecular Drug Research, and Drug Discovery Center for Infectious Disease, Nankai University, Tianjin 300350, China.

Elizabeth Joubert (E)

Plant Bioactives Group, Post-Harvest and Agro-Processing Technologies, Agricultural Research Council (ARC), Infruitec-Nietvoorbij, Private Bag X5026, Stellenbosch 7599, South Africa; Department of Food Science, Stellenbosch University, Private Bag X1, Matieland, Stellenbosch 7602, South Africa.

Jie Zhang (J)

Key Laboratory for Green Processing of Chemical Engineering of Xinjiang Bingtuan, School of Chemistry and Chemical Engineering, Shihezi University, Shihezi 832003, China.

Shen Li (S)

State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, Tianjin Key Laboratory of Molecular Drug Research, and Drug Discovery Center for Infectious Disease, Nankai University, Tianjin 300350, China.

Muhetaer Tuerhong (M)

College of Chemistry and Environmental Sciences, Laboratory of Xinjiang Native Medicinal and Edible Plant Resources Chemistry, Kashgar University, Kashgar 844000, China.

Munira Abudukeremu (M)

College of Chemistry and Environmental Sciences, Laboratory of Xinjiang Native Medicinal and Edible Plant Resources Chemistry, Kashgar University, Kashgar 844000, China.

Jin Jin (J)

State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, Tianjin Key Laboratory of Molecular Drug Research, and Drug Discovery Center for Infectious Disease, Nankai University, Tianjin 300350, China.

Jing Xu (J)

State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, Tianjin Key Laboratory of Molecular Drug Research, and Drug Discovery Center for Infectious Disease, Nankai University, Tianjin 300350, China. Electronic address: xujing611@nankai.edu.cn.

Dongho Lee (D)

Department of Biosystems and Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 136-713, Republic of Korea.

Yuanqiang Guo (Y)

State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, Tianjin Key Laboratory of Molecular Drug Research, and Drug Discovery Center for Infectious Disease, Nankai University, Tianjin 300350, China; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China. Electronic address: victgyq@nankai.edu.cn.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Viridiplantae › Streptophyta › Embryophyta › Tracheobionta › Magnoliopsida › Lamiales › Lamiaceae › Ajuga › Diterpenoids as potential anti-inflammatory...
questionsmedicales.fr › Eucaryotes › Animaux › Diterpenoids as potential anti-inflammatory...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-inflammatoires › Diterpenoids as potential anti-inflammatory...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Diterpenoids as potential anti-inflammatory...
questionsmedicales.fr › Composés hétérocycliques › Alcaloïdes › Alcaloïdes diterpéniques › Diterpènes de type clérodane › Diterpenoids as potential anti-inflammatory...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › Simulation de docking moléculaire › Diterpenoids as potential anti-inflammatory...
questionsmedicales.fr › Phénomènes chimiques › Structure moléculaire › Diterpenoids as potential anti-inflammatory...
questionsmedicales.fr › Facteurs biologiques › Composés phytochimiques › Diterpenoids as potential anti-inflammatory...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Poissons › Cypriniformes › Cyprinidae › Danio zébré › Diterpenoids as potential anti-inflammatory...