Reactive species generated by heme impair alveolar epithelial sodium channel function in acute respiratory distress syndrome.

Animals Epithelial Sodium Channels / genetics Heme Humans Lung Mice Pulmonary Alveoli Respiratory Distress Syndrome / chemically induced
Carbonylation Cell-free heme Epithelial sodium channel Halogenated lipids Hemopexin Spectrin

Journal

Redox biology
ISSN: 2213-2317
Titre abrégé: Redox Biol
Pays: Netherlands
ID NLM: 101605639

Informations de publication

Date de publication:
09 2020
Historique:
received: 25 03 2020
revised: 08 05 2020
accepted: 20 05 2020
pubmed: 9 6 2020
medline: 22 6 2021
entrez: 8 6 2020
Statut: ppublish

Résumé

We previously reported that the highly reactive cell-free heme (CFH) is increased in the plasma of patients with chronic lung injury and causes pulmonary edema in animal model of acute respiratory distress syndrome (ARDS) post inhalation of halogen gas. However, the mechanisms by which CFH causes pulmonary edema are unclear. Herein we report for the first time that CFH and chlorinated lipids (formed by the interaction of halogen gas, Cl

Identifiants

DOI: 10.1016/j.redox.2020.101592 PMID: 32506040 PMC: PMC7276446
pubmed: 32506040
pii: S2213-2317(20)30489-4
doi: 10.1016/j.redox.2020.101592
pmc: PMC7276446
pii:
doi:

Substances chimiques

Epithelial Sodium Channels 0
Heme 42VZT0U6YR

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

101592

Subventions

Organisme : NHLBI NIH HHS
ID : K12 HL143958
Pays : United States
Organisme : NIEHS NIH HHS
ID : R21 ES032956
Pays : United States
Organisme : NIEHS NIH HHS
ID : U01 ES026458
Pays : United States
Organisme : NIEHS NIH HHS
ID : U01 ES027697
Pays : United States

Informations de copyright

Copyright © 2020 The Authors. Published by Elsevier B.V. All rights reserved.

Auteurs

Saurabh Aggarwal (S)

Division of Molecular and Translational Biomedicine, USA; Pulmonary Injury and Repair Center, USA; Department of Anesthesiology and Perioperative Medicine, School of Medicine, University of Alabama at Birmingham, Birmingham, AL, 35205-3703, USA.

Ahmed Lazrak (A)

Division of Molecular and Translational Biomedicine, USA; Pulmonary Injury and Repair Center, USA; Department of Anesthesiology and Perioperative Medicine, School of Medicine, University of Alabama at Birmingham, Birmingham, AL, 35205-3703, USA.

Israr Ahmad (I)

Division of Molecular and Translational Biomedicine, USA; Department of Anesthesiology and Perioperative Medicine, School of Medicine, University of Alabama at Birmingham, Birmingham, AL, 35205-3703, USA.

Zhihong Yu (Z)

Division of Molecular and Translational Biomedicine, USA; Pulmonary Injury and Repair Center, USA; Department of Anesthesiology and Perioperative Medicine, School of Medicine, University of Alabama at Birmingham, Birmingham, AL, 35205-3703, USA.

Ayesha Bryant (A)

Division of Molecular and Translational Biomedicine, USA; Department of Anesthesiology and Perioperative Medicine, School of Medicine, University of Alabama at Birmingham, Birmingham, AL, 35205-3703, USA.

James A Mobley (JA)

Division of Molecular and Translational Biomedicine, USA; Pulmonary Injury and Repair Center, USA; Department of Anesthesiology and Perioperative Medicine, School of Medicine, University of Alabama at Birmingham, Birmingham, AL, 35205-3703, USA.

David A Ford (DA)

Department of Biochemistry and Molecular Biology, St. Louis University, St. Louis, MO, 63104, USA.

Sadis Matalon (S)

Division of Molecular and Translational Biomedicine, USA; Pulmonary Injury and Repair Center, USA; Department of Anesthesiology and Perioperative Medicine, School of Medicine, University of Alabama at Birmingham, Birmingham, AL, 35205-3703, USA. Electronic address: smatalon@uabmc.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Reactive species generated by heme impair...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Canaux ioniques › Canaux sodiques › Canaux sodium épithéliaux › Reactive species generated by heme impair...
questionsmedicales.fr › Facteurs biologiques › Pigments biologiques › Porphyrines › Métalloporphyrines › Hème › Reactive species generated by heme impair...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Reactive species generated by heme impair...
questionsmedicales.fr › Appareil respiratoire › Poumon › Reactive species generated by heme impair...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Reactive species generated by heme impair...
questionsmedicales.fr › Appareil respiratoire › Poumon › Alvéoles pulmonaires › Reactive species generated by heme impair...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Troubles respiratoires › Syndrome de détresse respiratoire de l'adulte › Reactive species generated by heme impair...