Metabolic heterogeneity and adaptability in brain tumors.
Cell communication
Glioma
Immune cells
Metabolism
Slow-cycling cells
Tumor initiating cells
Tumor microenvironment (TME)
Journal
Cellular and molecular life sciences : CMLS
ISSN: 1420-9071
Titre abrégé: Cell Mol Life Sci
Pays: Switzerland
ID NLM: 9705402
Informations de publication
Date de publication:
Dec 2020
Dec 2020
Historique:
received:
25
02
2020
accepted:
28
05
2020
revised:
18
05
2020
pubmed:
9
6
2020
medline:
25
11
2020
entrez:
8
6
2020
Statut:
ppublish
Résumé
The metabolic complexity and flexibility commonly observed in brain tumors, especially glioblastoma, is fundamental for their development and progression. The ability of tumor cells to modify their genetic landscape and adapt metabolically, subverts therapeutic efficacy, and inevitably instigates therapeutic resistance. To overcome these challenges and develop effective therapeutic strategies targeting essential metabolic processes, it is necessary to identify the mechanisms underlying heterogeneity and define metabolic preferences and liabilities of malignant cells. In this review, we will discuss metabolic diversity in brain cancer and highlight the role of cancer stem cells in regulating metabolic heterogeneity. We will also highlight potential therapeutic modalities targeting metabolic vulnerabilities and examine how intercellular metabolic signaling can shape the tumor microenvironment.
Identifiants
pubmed: 32506168
doi: 10.1007/s00018-020-03569-w
pii: 10.1007/s00018-020-03569-w
pmc: PMC8272080
mid: NIHMS1720334
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
5101-5119Subventions
Organisme : UFHCC Cancer Therapeutics & Host Response Research grant
ID : 00096885
Organisme : Florida Center for Brain Tumor Research & Accelerate Brain Cancer Cure
ID : P0058849
Organisme : American Brain Tumor Association
ID : DG1800014
Organisme : NCI NIH HHS
ID : P50 CA165962
Pays : United States
Organisme : Pray for Dominic St Baldrick's Research Grant
ID : 638733
Organisme : Medical Research Council
ID : MR/S007709/1
Pays : United Kingdom
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