Dynamics of hematopoiesis is disrupted by impaired hematopoietic microenvironment in a mouse model of hemophagocytic lymphohistiocytosis.
Animals
Bone Marrow
/ pathology
Bone Marrow Cells
/ pathology
Cell Count
Cells, Cultured
Cellular Microenvironment
/ physiology
Disease Models, Animal
Hematopoiesis
/ physiology
Hematopoietic Stem Cells
/ pathology
Lipopolysaccharides
Lymphohistiocytosis, Hemophagocytic
/ chemically induced
Male
Mice
Stem Cell Niche
/ physiology
Stromal Cells
/ pathology
Cytokine
Hematopoiesis
Hemophagocytic lymphohistiocytosis
Senescence-accelerated mouse
Stromal cell
Journal
Annals of hematology
ISSN: 1432-0584
Titre abrégé: Ann Hematol
Pays: Germany
ID NLM: 9107334
Informations de publication
Date de publication:
Jul 2020
Jul 2020
Historique:
received:
11
02
2020
accepted:
17
05
2020
pubmed:
9
6
2020
medline:
24
7
2020
entrez:
8
6
2020
Statut:
ppublish
Résumé
Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening systemic hyperinflammatory disorder. We found recently that repeated lipopolysaccharide (LPS) treatment induces HLH-like features in senescence-accelerated mice (SAMP1/TA-1) but not in senescence-resistant control mice (SAMR1). In this study, we analyzed the dynamics of hematopoiesis in this mouse model of HLH. When treated repeatedly with LPS, the numbers of myeloid progenitor cells (CFU-GM) and B-lymphoid progenitor cells (CFU-preB) in the bone marrow (BM) rapidly decreased after each treatment in both strains. The number of CFU-GM in SAMP1/TA-1 and SAMR1, and of CFU-preB in SAMR1, returned to pretreatment levels by 7 days after each treatment. However, the recovery in the number of CFU-preB in SAMP1/TA-1 was limited. In both strains, the BM expression of genes encoding positive regulators of myelopoiesis (granulocyte colony-stimulating factor (G-CSF), granulocyte macrophage colony-stimulating factor (GM-CSF), and interleukin (IL)-6), and negative regulators of B lymphopoiesis (tumor necrosis factor (TNF)-α) was increased. The expression of genes encoding positive regulators of B lymphopoiesis (stromal-cell derived factor (SDF)-1, IL-7, and stem cell factor (SCF)) was persistently decreased in SAMP1/TA-1 but not in SAMR1. Expression of the gene encoding p16
Identifiants
pubmed: 32506245
doi: 10.1007/s00277-020-04095-2
pii: 10.1007/s00277-020-04095-2
doi:
Substances chimiques
Lipopolysaccharides
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1515-1523Subventions
Organisme : The Japan society for the promotion of science
ID : JP18K06846
Références
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