Cholic acid and deoxycholic acid induce skeletal muscle atrophy through a mechanism dependent on TGR5 receptor.

Animals Cells, Cultured Cholic Acid / pharmacology Deoxycholic Acid / pharmacology Male Mice Mice, Inbred C57BL Muscle Fibers, Skeletal / drug effects Muscle Proteins / metabolism Muscle, Skeletal / drug effects Muscular Atrophy / chemically induced Myosin Heavy Chains / drug effects Oxidative Stress / drug effects Receptors, G-Protein-Coupled / metabolism Tripartite Motif Proteins / metabolism Ubiquitin-Protein Ligases / metabolism
ROS TGR5 receptor autophagy bile acids muscle atrophy muscle wasting ubiquitin-proteasome system

Journal

Journal of cellular physiology
ISSN: 1097-4652
Titre abrégé: J Cell Physiol
Pays: United States
ID NLM: 0050222

Informations de publication

Date de publication:
01 2021
Historique:
received: 04 02 2020
revised: 04 05 2020
accepted: 21 05 2020
pubmed: 9 6 2020
medline: 28 8 2021
entrez: 8 6 2020
Statut: ppublish

Résumé

Skeletal muscle atrophy is characterized by the degradation of myofibrillar proteins, such as myosin heavy chain or troponin. An increase in the expression of two muscle-specific E3 ligases, atrogin-1 and MuRF-1, and oxidative stress are involved in muscle atrophy. Patients with chronic liver diseases (CLD) develop muscle wasting. Several bile acids increase in plasma during cholestatic CLD, among them, cholic acid (CA) and deoxycholic acid (DCA). The receptor for bile acids, TGR5, is expressed in healthy skeletal muscles. TGR5 is involved in the regulation of muscle differentiation and metabolic changes. In this paper, we evaluated the participation of DCA and CA in the generation of an atrophic condition in myotubes and isolated fibers from the muscle extracted from wild-type (WT) and TGR5-deficient (TGR5

Identifiants

DOI: 10.1002/jcp.29839 PMID: 32506638
pubmed: 32506638
doi: 10.1002/jcp.29839
doi:

Substances chimiques

Gpbar1 protein, mouse 0
Muscle Proteins 0
Receptors, G-Protein-Coupled 0
Tripartite Motif Proteins 0
Deoxycholic Acid 005990WHZZ
Ubiquitin-Protein Ligases EC 2.3.2.27
Myosin Heavy Chains EC 3.6.4.1
Cholic Acid G1JO7801AE

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

260-272

Informations de copyright

© 2020 Wiley Periodicals LLC.

Références

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Auteurs

Johanna Abrigo (J)

Laboratory of Muscle Pathology, Fragility suand Aging, Department of Biological Sciences, Faculty of Life Sciences, Universidad Andres Bello Universidad Andres Bello, Santiago, Chile.
Millennium Institute on Immunology and Immunotherapy, Santiago, Chile.
Center for the Development of Nanoscience and Nanotechnology (CEDENNA), Universidad de Santiago de Chile, Santiago, Chile.

Francisco Gonzalez (F)

Laboratory of Muscle Pathology, Fragility suand Aging, Department of Biological Sciences, Faculty of Life Sciences, Universidad Andres Bello Universidad Andres Bello, Santiago, Chile.
Millennium Institute on Immunology and Immunotherapy, Santiago, Chile.
Center for the Development of Nanoscience and Nanotechnology (CEDENNA), Universidad de Santiago de Chile, Santiago, Chile.

Francisco Aguirre (F)

Laboratory of Muscle Pathology, Fragility suand Aging, Department of Biological Sciences, Faculty of Life Sciences, Universidad Andres Bello Universidad Andres Bello, Santiago, Chile.
Millennium Institute on Immunology and Immunotherapy, Santiago, Chile.
Center for the Development of Nanoscience and Nanotechnology (CEDENNA), Universidad de Santiago de Chile, Santiago, Chile.

Franco Tacchi (F)

Laboratory of Muscle Pathology, Fragility suand Aging, Department of Biological Sciences, Faculty of Life Sciences, Universidad Andres Bello Universidad Andres Bello, Santiago, Chile.
Millennium Institute on Immunology and Immunotherapy, Santiago, Chile.
Center for the Development of Nanoscience and Nanotechnology (CEDENNA), Universidad de Santiago de Chile, Santiago, Chile.

Andrea Gonzalez (A)

Laboratory of Muscle Pathology, Fragility suand Aging, Department of Biological Sciences, Faculty of Life Sciences, Universidad Andres Bello Universidad Andres Bello, Santiago, Chile.
Millennium Institute on Immunology and Immunotherapy, Santiago, Chile.
Center for the Development of Nanoscience and Nanotechnology (CEDENNA), Universidad de Santiago de Chile, Santiago, Chile.

María Paz Meza (MP)

Laboratory of Muscle Pathology, Fragility suand Aging, Department of Biological Sciences, Faculty of Life Sciences, Universidad Andres Bello Universidad Andres Bello, Santiago, Chile.
Millennium Institute on Immunology and Immunotherapy, Santiago, Chile.
Center for the Development of Nanoscience and Nanotechnology (CEDENNA), Universidad de Santiago de Chile, Santiago, Chile.

Felipe Simon (F)

Millennium Institute on Immunology and Immunotherapy, Santiago, Chile.
Millennium Nucleus of Ion Channels-Associated Diseases (MiNICAD), Universidad de Chile, Chile.
Laboratory of Integrative Physiopathology, Department of Biological Sciences, Faculty of Life Sciences, Universidad Andres Bello Universidad Andres Bello, Santiago, Chile.

Daniel Cabrera (D)

Departamento de Gastroenterología, Escuela de Medicina-Centro de Envejecimiento y Regeneración (CARE), Facultad de Ciencias Biológicas, Pontifica Universidad Católica de Chile, Santiago, Chile.
Facultad de Ciencias Médicas, Universidad Bernardo OHiggins, Santiago, Chile.

Marco Arrese (M)

Departamento de Gastroenterología, Escuela de Medicina-Centro de Envejecimiento y Regeneración (CARE), Facultad de Ciencias Biológicas, Pontifica Universidad Católica de Chile, Santiago, Chile.

Saul Karpen (S)

Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia.

Claudio Cabello-Verrugio (C)

Laboratory of Muscle Pathology, Fragility suand Aging, Department of Biological Sciences, Faculty of Life Sciences, Universidad Andres Bello Universidad Andres Bello, Santiago, Chile.
Millennium Institute on Immunology and Immunotherapy, Santiago, Chile.
Center for the Development of Nanoscience and Nanotechnology (CEDENNA), Universidad de Santiago de Chile, Santiago, Chile.
ORCID: 0000-0001-7273-2102

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Cholic acid and deoxycholic acid induce...
questionsmedicales.fr › Cellules › Cellules cultivées › Cholic acid and deoxycholic acid induce...
questionsmedicales.fr › Composés polycycliques › Composés à cycles fusionnés › Stéroïdes › Cholanes › Acides choliques › Acide cholique › Cholic acid and deoxycholic acid induce...
questionsmedicales.fr › Composés polycycliques › Composés à cycles fusionnés › Stéroïdes › Cholanes › Acides choliques › Acide désoxycholique › Cholic acid and deoxycholic acid induce...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Cholic acid and deoxycholic acid induce...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Cholic acid and deoxycholic acid induce...
questionsmedicales.fr › Cellules › Cellules musculaires › Fibres musculaires squelettiques › Cholic acid and deoxycholic acid induce...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines contractiles › Protéines du muscle › Cholic acid and deoxycholic acid induce...
questionsmedicales.fr › Tissus › Muscles › Muscle strié › Muscles squelettiques › Cholic acid and deoxycholic acid induce...
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Manifestations neurologiques › Manifestations neuromusculaires › Amyotrophie › Cholic acid and deoxycholic acid induce...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines du cytosquelette › Protéines des microfilaments › Myosines › Chaînes lourdes de myosine › Cholic acid and deoxycholic acid induce...
questionsmedicales.fr › Phénomènes physiologiques › Stress physiologique › Stress oxydatif › Cholic acid and deoxycholic acid induce...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs couplés aux protéines G › Cholic acid and deoxycholic acid induce...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines à motif tripartite › Cholic acid and deoxycholic acid induce...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Ligases › Ubiquitin-protein ligase complexes › Ubiquitin-protein ligases › Cholic acid and deoxycholic acid induce...