Gene-environment interaction: New insights into perceived parenting and social anxiety among adolescents.
Adolescence
gene–environment interactions
parenting
social anxiety
Journal
European psychiatry : the journal of the Association of European Psychiatrists
ISSN: 1778-3585
Titre abrégé: Eur Psychiatry
Pays: England
ID NLM: 9111820
Informations de publication
Date de publication:
08 06 2020
08 06 2020
Historique:
pubmed:
9
6
2020
medline:
30
4
2021
entrez:
9
6
2020
Statut:
epublish
Résumé
Social anxiety symptoms (SAS) are among the most common mental health problems during adolescence, and it has been shown that parenting influences the adolescent's level of social anxiety. In addition, it is now widely assumed that most mental health problems, including social anxiety, originate from a complex interplay between genes and environment. However, to date, gene-environment (G × E) interactions studies in the field of social anxiety remain limited. In this study, we have examined how 274 genes involved in different neurotransmission pathways interact with five aspects of perceived parenting as environmental exposure (i.e., support, proactive control, psychological control, punitive control, and harsh punitive control) to affect SAS during adolescence. We have applied an analytical technique that allows studying genetic information at the gene level, by aggregating data from multiple single-nucleotide-polymorphisms within the same gene and by taking into account the linkage disequilibrium structure of the gene. All participants were part of the STRATEGIES cohort of 948 Flemish adolescents (mean age = 13.7), a population-based study on the development of problem behaviors in adolescence. Relevant genes were preselected based on prior findings and neurotransmitter-related functional protein networks. The results suggest that genes involved in glutamate (SLC1A1), glutathione neurotransmission (GSTZ1), and oxidative stress (CALCRL), in association with harsh punitive parenting, may contribute to social anxiety in adolescence. Isolated polymorphisms in these genes have been related to anxiety and related disorders in earlier work.Conclusions: Taken together, these findings provide new insights into possible biological pathways and environmental risk factors involved in the etiology of social anxiety symptoms' development. Taken together, these findings provide new insights into possible biological pathways and environmental risk factors involved in the etiology of social anxiety symptoms' development.
Sections du résumé
BACKGROUND
Social anxiety symptoms (SAS) are among the most common mental health problems during adolescence, and it has been shown that parenting influences the adolescent's level of social anxiety. In addition, it is now widely assumed that most mental health problems, including social anxiety, originate from a complex interplay between genes and environment. However, to date, gene-environment (G × E) interactions studies in the field of social anxiety remain limited. In this study, we have examined how 274 genes involved in different neurotransmission pathways interact with five aspects of perceived parenting as environmental exposure (i.e., support, proactive control, psychological control, punitive control, and harsh punitive control) to affect SAS during adolescence.
METHODS
We have applied an analytical technique that allows studying genetic information at the gene level, by aggregating data from multiple single-nucleotide-polymorphisms within the same gene and by taking into account the linkage disequilibrium structure of the gene. All participants were part of the STRATEGIES cohort of 948 Flemish adolescents (mean age = 13.7), a population-based study on the development of problem behaviors in adolescence. Relevant genes were preselected based on prior findings and neurotransmitter-related functional protein networks.
RESULTS
The results suggest that genes involved in glutamate (SLC1A1), glutathione neurotransmission (GSTZ1), and oxidative stress (CALCRL), in association with harsh punitive parenting, may contribute to social anxiety in adolescence. Isolated polymorphisms in these genes have been related to anxiety and related disorders in earlier work.Conclusions: Taken together, these findings provide new insights into possible biological pathways and environmental risk factors involved in the etiology of social anxiety symptoms' development.
CONCLUSIONS
Taken together, these findings provide new insights into possible biological pathways and environmental risk factors involved in the etiology of social anxiety symptoms' development.
Identifiants
pubmed: 32507125
doi: 10.1192/j.eurpsy.2020.62
pii: S0924933820000620
pmc: PMC7355173
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e64Références
J Abnorm Child Psychol. 2012 Nov;40(8):1363-73
pubmed: 22821448
Dev Psychopathol. 2018 May;30(2):449-459
pubmed: 28606214
Curr Cardiol Rep. 2017 Sep 20;19(11):111
pubmed: 28932967
Cytogenet Cell Genet. 1998;83(1-2):109-14
pubmed: 9925947
Dialogues Clin Neurosci. 2017 Jun;19(2):127-136
pubmed: 28867937
Psychol Bull. 2009 Nov;135(6):885-908
pubmed: 19883141
Int J Behav Healthc Res. 2011 Oct;2(4):320-332
pubmed: 25383095
J Abnorm Child Psychol. 2016 Oct;44(7):1267-78
pubmed: 26783026
J Child Psychol Psychiatry. 2017 Dec;58(12):1301-1309
pubmed: 28660714
Eur Arch Psychiatry Clin Neurosci. 2004 Dec;254(6):397-405
pubmed: 15538600
J Anxiety Disord. 2014 Dec;28(8):902-7
pubmed: 25445080
Protein Sci. 2012 Feb;21(2):199-210
pubmed: 22102369
Arch Gen Psychiatry. 1998 Jan;55(1):56-64
pubmed: 9435761
Psychiatry Res. 2014 Oct 30;224(1):34-41
pubmed: 25156662
Am J Med Genet B Neuropsychiatr Genet. 2017 Mar;174(2):120-131
pubmed: 28224735
J Biol Chem. 1996 May 10;271(19):11325-9
pubmed: 8626685
Neuropsychiatr. 2018 Dec;32(4):187-195
pubmed: 30218392
Am J Epidemiol. 2017 Oct 1;186(7):762-770
pubmed: 28978192
PLoS One. 2013;8(4):e58676
pubmed: 23565138
J Anxiety Disord. 2011 Jan;25(1):131-7
pubmed: 20832989
Assessment. 2019 Jan;26(1):111-124
pubmed: 28076976
Nucleic Acids Res. 2013 Jan;41(Database issue):D808-15
pubmed: 23203871
J Mol Biol. 2000 Jun 16;299(4):897-905
pubmed: 10843846
J Adolesc. 2017 Oct;60:11-15
pubmed: 28738315
Neuroimage. 2016 Jul 1;134:671-684
pubmed: 27109357
Dev Psychol. 2014 Feb;50(2):577-85
pubmed: 23815705
Assessment. 2019 Mar;26(2):235-248
pubmed: 28052690
Ann Med. 2008;40(2):92-109
pubmed: 18293140
Genet Res (Camb). 2010 Dec;92(5-6):381-95
pubmed: 21429270
Nat Protoc. 2010 Sep;5(9):1564-73
pubmed: 21085122
Psychiatry Res. 2013 Oct 30;209(3):737-9
pubmed: 23411042
J Autism Dev Disord. 2010 Sep;40(9):1139-45
pubmed: 20155310
Psychol Med. 1999 May;29(3):569-82
pubmed: 10405078
Psychol Bull. 2009 Jul;135(4):608-37
pubmed: 19586164
J Abnorm Child Psychol. 1998 Apr;26(2):83-94
pubmed: 9634131
Genome Res. 2011 Jul;21(7):1109-21
pubmed: 21536720
Biol Psychiatry. 2014 Jan 1;75(1):18-24
pubmed: 24135711
Curr Opin Neurol. 2015 Jun;28(3):250-4
pubmed: 25887765
Brain Imaging Behav. 2009 Mar 1;3(1):64-76
pubmed: 21031159
J Anxiety Disord. 2014 Oct;28(7):650-6
pubmed: 25118017
Front Hum Neurosci. 2017 Jun 20;11:316
pubmed: 28676747
PLoS Genet. 2008 Feb 29;4(2):e1000008
pubmed: 18454194
Nature. 2009 Aug 6;460(7256):748-52
pubmed: 19571811
Biometrics. 1999 Dec;55(4):997-1004
pubmed: 11315092
Arch Gen Psychiatry. 2006 Jul;63(7):778-85
pubmed: 16818867
Behav Brain Res. 2015 Apr 1;282:201-8
pubmed: 25591473
Biochim Biophys Acta. 2013 May;1830(5):3267-88
pubmed: 23201197
Biol Psychiatry. 2007 May 15;61(10):1121-6
pubmed: 17346679
Assessment. 2015 Aug;22(4):473-89
pubmed: 25225229
Depress Anxiety. 2009;26(11):1027-32
pubmed: 19750554
J Child Psychol Psychiatry. 2007 Dec;48(12):1174-83
pubmed: 18093022
Psychiatry Res. 2012 Jun 30;198(1):166-8
pubmed: 22374552
Depress Anxiety. 2016 Jan;33(1):27-34
pubmed: 26418232
Infant Child Dev. 2018 Jul-Aug;27(4):
pubmed: 30147452
Neuropsychopharmacology. 2013 Aug;38(9):1648-54
pubmed: 23463151