Bacterial Peptidoglycans from Microbiota in Neurodevelopment and Behavior.
HPA axis
NOD-like receptors
anxiety-like behavior
cognition
microbiome
peptidoglycan recognition proteins
placenta
pregnancy
Journal
Trends in molecular medicine
ISSN: 1471-499X
Titre abrégé: Trends Mol Med
Pays: England
ID NLM: 100966035
Informations de publication
Date de publication:
08 2020
08 2020
Historique:
received:
11
03
2020
revised:
05
05
2020
accepted:
08
05
2020
pubmed:
9
6
2020
medline:
8
7
2021
entrez:
9
6
2020
Statut:
ppublish
Résumé
It is increasingly recognized that the gut microbiota profoundly influences many aspects of host development and physiology, including the modulation of brain development and behavior. However, the precise molecular mechanisms and signaling pathways involved in communication between the microbiota and the developing brain remain to be fully elucidated. Germline-encoded pattern-recognition receptors (PRRs) that recognize conserved microbial molecular signatures such as bacterial surface molecules (e.g., peptidoglycans, PGNs) have emerged as potential key regulators of gut microbiota-brain interactions. We highlight current evidence supporting multiple and essential roles for PGNs and their sensing molecules beyond innate immunity, extending to neurodevelopment and behavior. In addition, the possible implications of the PGN signaling pathway for the pathogenesis of neurodevelopmental disorders such as autism spectrum disorder (ASD) are considered.
Identifiants
pubmed: 32507655
pii: S1471-4914(20)30132-5
doi: 10.1016/j.molmed.2020.05.003
pii:
doi:
Substances chimiques
Peptidoglycan
0
Receptors, Pattern Recognition
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
729-743Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.