Association of Dietary Fatty Acid Intake With the Development of Ulcerative Colitis: A Multicenter Case-Control Study in Japan.
case-control study
dietary fatty acid intake
ulcerative colitis
Journal
Inflammatory bowel diseases
ISSN: 1536-4844
Titre abrégé: Inflamm Bowel Dis
Pays: England
ID NLM: 9508162
Informations de publication
Date de publication:
15 04 2021
15 04 2021
Historique:
received:
13
10
2019
pubmed:
9
6
2020
medline:
9
2
2022
entrez:
9
6
2020
Statut:
ppublish
Résumé
Dietary fatty acids can affect chronic intestinal inflammation and have been reported to be associated with the development of ulcerative colitis (UC), mainly in Europe and the United States. The association of dietary intake of fatty acids and the risk for UC was investigated in Japan, where dietary habits lead to lower meat and higher fish consumption than in Western countries. A multicenter case-control study of 83 newly diagnosed patients with UC and 128 age- and sex-matched control patients in the hospital was conducted from 2008 to 2014. Dietary fatty acid intake in the preceding 1 month and 1 year were examined using a self-administered diet history questionnaire that was developed for Japanese people. About 92% of patients had experienced the first symptoms of UC within the preceding 11 months. Regarding dietary habits in the preceding year, the risk for UC was significantly decreased in patients who consumed n-6/n-3 polyunsaturated fatty acids at a ratio of ≥5.2 (odds ratio [OR] = 0.26; 95% confidence interval [CI], 0.10-0.68). Conversely, an increased risk for UC was observed in the highest tertiles of consumption of docosahexaenoic acid (OR = 7.22; 95% CI, 2.09-24.95), eicosapentaenoic acid (OR = 6.91; 95% CI, 1.88-25.44), and docosapentaenoic acid (OR = 4.83; 95% CI, 1.56-14.95). The ratio of n-6/n-3 polyunsaturated fatty acid intake was associated with a decreased risk for UC development. However, high intakes of docosahexaenoic acid, eicosapentaenoic acid, and docosapentaenoic acid may increase the risk for UC development.
Sections du résumé
BACKGROUND
Dietary fatty acids can affect chronic intestinal inflammation and have been reported to be associated with the development of ulcerative colitis (UC), mainly in Europe and the United States. The association of dietary intake of fatty acids and the risk for UC was investigated in Japan, where dietary habits lead to lower meat and higher fish consumption than in Western countries.
METHODS
A multicenter case-control study of 83 newly diagnosed patients with UC and 128 age- and sex-matched control patients in the hospital was conducted from 2008 to 2014. Dietary fatty acid intake in the preceding 1 month and 1 year were examined using a self-administered diet history questionnaire that was developed for Japanese people.
RESULTS
About 92% of patients had experienced the first symptoms of UC within the preceding 11 months. Regarding dietary habits in the preceding year, the risk for UC was significantly decreased in patients who consumed n-6/n-3 polyunsaturated fatty acids at a ratio of ≥5.2 (odds ratio [OR] = 0.26; 95% confidence interval [CI], 0.10-0.68). Conversely, an increased risk for UC was observed in the highest tertiles of consumption of docosahexaenoic acid (OR = 7.22; 95% CI, 2.09-24.95), eicosapentaenoic acid (OR = 6.91; 95% CI, 1.88-25.44), and docosapentaenoic acid (OR = 4.83; 95% CI, 1.56-14.95).
CONCLUSIONS
The ratio of n-6/n-3 polyunsaturated fatty acid intake was associated with a decreased risk for UC development. However, high intakes of docosahexaenoic acid, eicosapentaenoic acid, and docosapentaenoic acid may increase the risk for UC development.
Identifiants
pubmed: 32507894
pii: 5854441
doi: 10.1093/ibd/izaa140
doi:
Substances chimiques
Fatty Acids, Unsaturated
0
Docosahexaenoic Acids
25167-62-8
Eicosapentaenoic Acid
AAN7QOV9EA
docosapentaenoic acid
NS3OZT14QT
Types de publication
Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
617-628Investigateurs
Masahiro Iizuka
(M)
Yutaka Kohgo
(Y)
Yuhei Inaba
(Y)
Takashi Hisabe
(T)
Toshiyuki Matsui
(T)
Kitaro Futami
(K)
Hiroyuki Hanai
(H)
Yoh Ishiguro
(Y)
Shinji Tanaka
(S)
Yoshitaka Ueno
(Y)
Kenji Watanabe
(K)
Hiroki Ikeuchi
(H)
Hiroshi Fujita
(H)
Hirohito Tsubouchi
(H)
Kazuichi Okazaki
(K)
Kazuhiko Yoshioka
(K)
Nagamu Inoue
(N)
Toshifumi Hibi
(T)
Kiyonori Kobayashi
(K)
Kaoru Yokoyama
(K)
Hiroshi Yamasaki
(H)
Keiichi Mitsuyama
(K)
Yuji Naito
(Y)
Tsutomu Chiba
(T)
Hiroshi Nakase
(H)
Masato Kusunoki
(M)
Haruhiko Inatsu
(H)
Shojiro Yamamoto
(S)
Hisao Fujii
(H)
Ryota Hokari
(R)
Soichiro Miura
(S)
Kazuhito Sugimura
(K)
Hideki Iijima
(H)
Satoshi Motoya
(S)
Akira Andoh
(A)
Yoshihide Fujiyama
(Y)
Shunji Ishihara
(S)
Shin-Ei Kudo
(SE)
Noriyuki Ogata
(N)
Naoki Yoshimura
(N)
Toshiaki Watanabe
(T)
Kazuo Ohtsuka
(K)
Mamoru Watanabe
(M)
Shingo Kameoka
(S)
Michio Itabashi
(M)
Yuji Funayama
(Y)
Fukunori Kinjo
(F)
Atsuo Kitano
(A)
Atsushi Nakajima
(A)
Hirokazu Takahashi
(H)
Takuma Higurashi
(T)
Akira Sugita
(A)
Informations de copyright
© 2020 Crohn’s & Colitis Foundation. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.