Effect of Aerobic Physical Exercise in an Animal Model of Duchenne Muscular Dystrophy.
Animal
Duchenne muscular dystrophy
Muscle
Oxidative stress
Physical exercise
Journal
Journal of molecular neuroscience : MN
ISSN: 1559-1166
Titre abrégé: J Mol Neurosci
Pays: United States
ID NLM: 9002991
Informations de publication
Date de publication:
Oct 2020
Oct 2020
Historique:
received:
14
10
2019
accepted:
22
04
2020
pubmed:
9
6
2020
medline:
30
6
2021
entrez:
9
6
2020
Statut:
ppublish
Résumé
Duchenne muscular dystrophy (DMD) is a condition caused by an amendment to the X chromosome, inherited as a recessive trait, and affects 1:3500 live births, especially males. Low-intensity exercise is known to decrease certain parameters associated with muscular degeneration in animal models of progressive muscular dystrophies. In the present study, 28-day-old male mdx and wild-type (wild) mice were used. The animals were subjected to a low-intensity physical exercise protocol for 8 weeks. It was found that this protocol was able to reduce oxidative stress in muscle tissue and in most of the CNS structures analyzed, with a significant increase in antioxidant activity in all analyzed structures. It is thus possible to infer that this exercise protocol was able to reduce oxidative stress and improve the energy metabolism in brain tissue and in the gastrocnemius muscle of animals with DMD.
Identifiants
pubmed: 32507928
doi: 10.1007/s12031-020-01565-0
pii: 10.1007/s12031-020-01565-0
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
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