Tetraspanins in the regulation of mast cell function.
Allergy
Antiviral immune response
Exosomes
FcεRI
Mast cell degranulation
Mast cells
Tetraspanins
Journal
Medical microbiology and immunology
ISSN: 1432-1831
Titre abrégé: Med Microbiol Immunol
Pays: Germany
ID NLM: 0314524
Informations de publication
Date de publication:
Aug 2020
Aug 2020
Historique:
received:
17
02
2020
accepted:
06
05
2020
pubmed:
9
6
2020
medline:
26
1
2021
entrez:
9
6
2020
Statut:
ppublish
Résumé
Mast cells (MCs) are long-living immune cells highly specialized in the storage and release of different biologically active compounds and are involved in the regulation of innate and adaptive immunity. MC degranulation and replacement of MC granules are accompanied by active membrane remodelling. Tetraspanins represent an evolutionary conserved family of transmembrane proteins. By interacting with lipids and other membrane and intracellular proteins, they are involved in organisation of membrane protein complexes and act as "molecular facilitators" connecting extracellular and cytoplasmic signaling elements. MCs express different tetraspanins and MC degranulation is accompanied by changes in membrane organisation. Therefore, tetraspanins are very likely involved in the regulation of MC exocytosis and membrane reorganisation after degranulation. Antiviral response and production of exosomes are further aspects of MC function characterized by dynamic changes of membrane organization. In this review, we pay a particular attention to tetraspanin gene expression in different human and murine MC populations, discuss tetraspanin involvement in regulation of key MC signaling complexes, and analyze the potential contribution of tetraspanins to MC antiviral response and exosome production. In-depth knowledge of tetraspanin-mediated molecular mechanisms involved in different aspects of the regulation of MC response will be beneficial for patients with allergies, characterized by overwhelming MC reactions.
Identifiants
pubmed: 32507938
doi: 10.1007/s00430-020-00679-x
pii: 10.1007/s00430-020-00679-x
pmc: PMC7395004
doi:
Substances chimiques
Tetraspanins
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
531-543Subventions
Organisme : Deutsche Forschungsgemeinschaft
ID : GRK1727
Organisme : Deutsche Forschungsgemeinschaft
ID : B5
Organisme : Grantová Agentura České Republiky
ID : 20-16481S
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