CpG-creating mutations are costly in many human viruses.
CpG sites
Fitness costs
Mutations
Viruses
Journal
Evolutionary ecology
ISSN: 0269-7653
Titre abrégé: Evol Ecol
Pays: Germany
ID NLM: 9882858
Informations de publication
Date de publication:
2020
2020
Historique:
received:
05
07
2019
accepted:
11
03
2020
entrez:
9
6
2020
pubmed:
9
6
2020
medline:
9
6
2020
Statut:
ppublish
Résumé
Mutations can occur throughout the virus genome and may be beneficial, neutral or deleterious. We are interested in mutations that yield a C next to a G, producing CpG sites. CpG sites are rare in eukaryotic and viral genomes. For the eukaryotes, it is thought that CpG sites are rare because they are prone to mutation when methylated. In viruses, we know less about why CpG sites are rare. A previous study in HIV suggested that CpG-creating transition mutations are more costly than similar non-CpG-creating mutations. To determine if this is the case in other viruses, we analyzed the allele frequencies of CpG-creating and non-CpG-creating mutations across various strains, subtypes, and genes of viruses using existing data obtained from Genbank, HIV Databases, and Virus Pathogen Resource. Our results suggest that CpG sites are indeed costly for most viruses. By understanding the cost of CpG sites, we can obtain further insights into the evolution and adaptation of viruses.
Identifiants
pubmed: 32508375
doi: 10.1007/s10682-020-10039-z
pii: 10039
pmc: PMC7245597
doi:
Types de publication
Journal Article
Langues
eng
Pagination
339-359Subventions
Organisme : NIGMS NIH HHS
ID : R25 GM048972
Pays : United States
Organisme : NIGMS NIH HHS
ID : R25 GM059298
Pays : United States
Organisme : NIGMS NIH HHS
ID : T34 GM008574
Pays : United States
Informations de copyright
© The Author(s) 2020.
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