Transcranial Static Magnetic Field Stimulation of the Motor Cortex in Children.
motor learning
neuromodulation
neurophysiology
non-invasive brain stimulation
pediatrics
tSMS
Journal
Frontiers in neuroscience
ISSN: 1662-4548
Titre abrégé: Front Neurosci
Pays: Switzerland
ID NLM: 101478481
Informations de publication
Date de publication:
2020
2020
Historique:
received:
10
09
2019
accepted:
15
04
2020
entrez:
9
6
2020
pubmed:
9
6
2020
medline:
9
6
2020
Statut:
epublish
Résumé
Non-invasive neuromodulation is an emerging therapy for children with early brain injury but is difficult to apply to preschoolers when windows of developmental plasticity are optimal. Transcranial static magnetic field stimulation (tSMS) decreases primary motor cortex (M1) excitability in adults but effects on the developing brain are unstudied. We aimed to determine the effects of tSMS on cortical excitability and motor learning in healthy children. We hypothesized that tSMS over right M1 would reduce cortical excitability and inhibit contralateral motor learning. This randomized, sham-controlled, double-blinded, three-arm, cross-over trial enrolled 24 healthy children aged 10-18 years. Transcranial Magnetic Stimulation (TMS) assessed cortical excitability via motor-evoked potential (MEP) amplitude and paired pulse measures. Motor learning was assessed via the Purdue Pegboard Test (PPT). A tSMS magnet (677 Newtons) or sham was held over left or right M1 for 30 min while participants trained the non-dominant hand. A linear mixed effect model was used to examine intervention effects. All 72 tSMS sessions were well tolerated without serious adverse effects. Neither cortical excitability as measured by MEPs nor paired-pulse intracortical neurophysiology was altered by tSMS. Possible behavioral effects included contralateral tSMS inhibiting early motor learning ( tSMS is feasible in pediatric populations. Unlike adults, tSMS did not produce measurable changes in MEP amplitude. Possible effects of M1 tSMS on motor learning require further study. Our findings support further exploration of tSMS neuromodulation in young children with cerebral palsy.
Sections du résumé
BACKGROUND
BACKGROUND
Non-invasive neuromodulation is an emerging therapy for children with early brain injury but is difficult to apply to preschoolers when windows of developmental plasticity are optimal. Transcranial static magnetic field stimulation (tSMS) decreases primary motor cortex (M1) excitability in adults but effects on the developing brain are unstudied.
OBJECTIVE/HYPOTHESIS
OBJECTIVE
We aimed to determine the effects of tSMS on cortical excitability and motor learning in healthy children. We hypothesized that tSMS over right M1 would reduce cortical excitability and inhibit contralateral motor learning.
METHODS
METHODS
This randomized, sham-controlled, double-blinded, three-arm, cross-over trial enrolled 24 healthy children aged 10-18 years. Transcranial Magnetic Stimulation (TMS) assessed cortical excitability via motor-evoked potential (MEP) amplitude and paired pulse measures. Motor learning was assessed via the Purdue Pegboard Test (PPT). A tSMS magnet (677 Newtons) or sham was held over left or right M1 for 30 min while participants trained the non-dominant hand. A linear mixed effect model was used to examine intervention effects.
RESULTS
RESULTS
All 72 tSMS sessions were well tolerated without serious adverse effects. Neither cortical excitability as measured by MEPs nor paired-pulse intracortical neurophysiology was altered by tSMS. Possible behavioral effects included contralateral tSMS inhibiting early motor learning (
CONCLUSION
CONCLUSIONS
tSMS is feasible in pediatric populations. Unlike adults, tSMS did not produce measurable changes in MEP amplitude. Possible effects of M1 tSMS on motor learning require further study. Our findings support further exploration of tSMS neuromodulation in young children with cerebral palsy.
Identifiants
pubmed: 32508570
doi: 10.3389/fnins.2020.00464
pmc: PMC7248312
doi:
Types de publication
Journal Article
Langues
eng
Pagination
464Informations de copyright
Copyright © 2020 Hollis, Zewdie, Nettel-Aguirre, Hilderley, Kuo, Carlson and Kirton.
Références
Clin Neurophysiol. 2008 May;119(5):973-84
pubmed: 18221913
J Physiol. 2010 Jul 1;588(Pt 13):2291-304
pubmed: 20478978
Brain Stimul. 2018 Jul - Aug;11(4):676-688
pubmed: 29500043
Proc Natl Acad Sci U S A. 2009 Feb 3;106(5):1590-5
pubmed: 19164589
Clin Neurophysiol. 2015 Jul;126(7):1392-9
pubmed: 25468234
Lancet Child Adolesc Health. 2018 Sep;2(9):666-676
pubmed: 30119760
Neurosci Biobehav Rev. 2007;31(8):1125-35
pubmed: 17599407
Neurosci Biobehav Rev. 2007;31(8):1150-6
pubmed: 17624432
Clin Neurophysiol. 2015 Dec;126(12):2314-9
pubmed: 25792074
Exp Brain Res. 2006 Sep;174(2):376-85
pubmed: 16636787
Brain Stimul. 2013 May;6(3):424-32
pubmed: 22695026
Proc Natl Acad Sci U S A. 2000 Mar 28;97(7):3661-5
pubmed: 10716702
Front Neural Circuits. 2018 Sep 25;12:80
pubmed: 30310380
J Physiol. 2013 Apr 1;591(7):1987-2000
pubmed: 23339180
Neuroreport. 2006 Apr 24;17(6):671-4
pubmed: 16603933
Brain Stimul. 2016 Sep-Oct;9(5):641-661
pubmed: 27372845
Health Phys. 2009 Apr;96(4):504-14
pubmed: 19276710
BMJ. 2010 Mar 23;340:c332
pubmed: 20332509
Stroke. 2012 Jul;43(7):1849-57
pubmed: 22713491
Cephalalgia. 2018 Jul;38(8):1493-1497
pubmed: 29020806
Exp Brain Res. 2013 Feb;224(3):411-6
pubmed: 23178905
J Neurosci. 2015 Jun 17;35(24):9182-93
pubmed: 26085640
Neuromodulation. 2018 Jun;21(4):340-347
pubmed: 29024263
J Appl Psychol. 1948 Jun;32(3):234-47
pubmed: 18867059
Funct Neurol. 2017 Apr/Jun;32(2):77-82
pubmed: 28676140
Exp Brain Res. 2001 Feb;136(4):431-8
pubmed: 11291723
Neurosci Biobehav Rev. 2007;31(8):1136-49
pubmed: 18053875
Neurosci Lett. 2019 Mar 23;696:33-37
pubmed: 30552943
Front Cell Neurosci. 2015 May 12;9:181
pubmed: 26029052
Dev Med Child Neurol. 2013 Nov;55 Suppl 4:27-31
pubmed: 24237276
Cell Biochem Biophys. 2003;39(2):163-73
pubmed: 14515021
Brain Stimul. 2015 May-Jun;8(3):481-5
pubmed: 25595064
Dev Med Child Neurol. 2016 Feb;58(2):160-6
pubmed: 26010819
J Neurol Sci. 2016 Mar 15;362:209-16
pubmed: 26944150
Ann Neurol. 2007 Nov;62(5):493-503
pubmed: 17444535
Stroke. 2013 Nov;44(11):3265-71
pubmed: 24105698
Dev Med Child Neurol. 2011 Sep;53 Suppl 4:9-13
pubmed: 21950387
J Neurophysiol. 2017 Jul 1;118(1):140-148
pubmed: 28381485
Cereb Cortex. 2017 May 1;27(5):2758-2767
pubmed: 27166171
J Neuroeng Rehabil. 2017 Sep 13;14(1):95
pubmed: 28903772
Front Neurosci. 2018 Oct 31;12:787
pubmed: 30429768
Front Neurol. 2014 Nov 24;5:229
pubmed: 25505443
Brain Stimul. 2017 May - Jun;10(3):703-710
pubmed: 28302459
Front Hum Neurosci. 2018 Jul 03;12:268
pubmed: 30018543
Clin Neurophysiol Pract. 2018 Feb 23;3:49-53
pubmed: 30215008
Arch Phys Med Rehabil. 2015 Apr;96(4 Suppl):S104-13
pubmed: 25283350
Brain Stimul. 2017 Jul - Aug;10(4):867
pubmed: 28438545
Front Cell Neurosci. 2015 Sep 01;9:335
pubmed: 26388729
Phys Ther. 2010 Mar;90(3):398-410
pubmed: 20110339
Neurology. 2016 May 3;86(18):1659-67
pubmed: 27029628
J Physiol. 2011 Oct 15;589(Pt 20):4949-58
pubmed: 21807616
Curr Opin Neurol. 2011 Dec;24(6):590-6
pubmed: 21968548
Dev Med Child Neurol. 2014 Jan;56(1):44-52
pubmed: 23962321
Sci Rep. 2016 Oct 04;6:34509
pubmed: 27698365
Pediatr Neurol. 2013 Feb;48(2):81-94
pubmed: 23337000
Exp Brain Res. 2010 Aug;205(1):57-68
pubmed: 20574685
Eur J Paediatr Neurol. 2018 May;22(3):358-368
pubmed: 29456128
J Neurosci. 2017 Apr 5;37(14):3840-3847
pubmed: 28280254
Eur J Paediatr Neurol. 2004;8(1):7-19
pubmed: 15023371
Dev Med Child Neurol. 2007 Aug;49(8):564
pubmed: 17635196
Brain Stimul. 2013 Sep;6(5):817-20
pubmed: 23598254
Front Hum Neurosci. 2016 Nov 25;10:598
pubmed: 27932966
Neurology. 2017 Jan 17;88(3):259-267
pubmed: 27927938