Postretrieval Microinjection of Baclofen Into the Agranular Insular Cortex Inhibits Morphine-Induced CPP by Disrupting Reconsolidation.

agranular insular cortex baclofen conditioned place preference morphine addiction reconsolidation

Journal

Frontiers in pharmacology
ISSN: 1663-9812
Titre abrégé: Front Pharmacol
Pays: Switzerland
ID NLM: 101548923

Informations de publication

Date de publication:
2020
Historique:
received: 20 12 2019
accepted: 04 05 2020
entrez: 9 6 2020
pubmed: 9 6 2020
medline: 9 6 2020
Statut: epublish

Résumé

Environmental cues associated with drug abuse are powerful mediators of drug craving and relapse in substance-abuse disorders. Consequently, attenuating the strength of cue-drug memories could reduce the number of factors that cause drug craving and relapse. Interestingly, impairing cue-drug memory reconsolidation is a generally accepted strategy aimed at reducing the intensity of cues that trigger drug-seeking and drug-taking behaviors. In addition, the agranular insular cortex (AI) is an important component of the neural circuits underlying drug-related memory reconsolidation. GABA

Identifiants

pubmed: 32508658
doi: 10.3389/fphar.2020.00743
pmc: PMC7248341
doi:

Types de publication

Journal Article

Langues

eng

Pagination

743

Informations de copyright

Copyright © 2020 Sun, Mu, Chang, Zhang, Wang, Rong, Liu, Zuo, He, Wan, Yang, Wang and Sun.

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Auteurs

Kuisheng Sun (K)

Ningxia Key Laboratory of Cerebrocranial Disease, Incubation Base of National Key Laboratory, Ningxia Medical University, Yinchuan, China.
Department of Neurosurgery, General Hospital of Ningxia Medical University, Yinchuan, China.
Department of Neurosurgery, The People's Hospital of Gaozhou, Gaozhou, China.

Qingchun Mu (Q)

Department of Neurosurgery, The People's Hospital of Gaozhou, Gaozhou, China.

Haigang Chang (H)

Ningxia Key Laboratory of Cerebrocranial Disease, Incubation Base of National Key Laboratory, Ningxia Medical University, Yinchuan, China.
Department of Neurosurgery, General Hospital of Ningxia Medical University, Yinchuan, China.

Chun Zhang (C)

Ningxia Key Laboratory of Cerebrocranial Disease, Incubation Base of National Key Laboratory, Ningxia Medical University, Yinchuan, China.

Yehua Wang (Y)

Ningxia Key Laboratory of Cerebrocranial Disease, Incubation Base of National Key Laboratory, Ningxia Medical University, Yinchuan, China.

Shikuo Rong (S)

Ningxia Key Laboratory of Cerebrocranial Disease, Incubation Base of National Key Laboratory, Ningxia Medical University, Yinchuan, China.

Shenhai Liu (S)

Ningxia Key Laboratory of Cerebrocranial Disease, Incubation Base of National Key Laboratory, Ningxia Medical University, Yinchuan, China.

Di Zuo (D)

Ningxia Key Laboratory of Cerebrocranial Disease, Incubation Base of National Key Laboratory, Ningxia Medical University, Yinchuan, China.

Zhenquan He (Z)

Ningxia Key Laboratory of Cerebrocranial Disease, Incubation Base of National Key Laboratory, Ningxia Medical University, Yinchuan, China.

Ding Wan (D)

Ningxia Key Laboratory of Cerebrocranial Disease, Incubation Base of National Key Laboratory, Ningxia Medical University, Yinchuan, China.
Department of Neurosurgery, General Hospital of Ningxia Medical University, Yinchuan, China.

Hua Yang (H)

Department of Critical Care Medicine, The People's Hospital of Ningxia Hui Autonomous Region, Yinchuan, China.

Feng Wang (F)

Ningxia Key Laboratory of Cerebrocranial Disease, Incubation Base of National Key Laboratory, Ningxia Medical University, Yinchuan, China.
Department of Neurosurgery, General Hospital of Ningxia Medical University, Yinchuan, China.

Tao Sun (T)

Ningxia Key Laboratory of Cerebrocranial Disease, Incubation Base of National Key Laboratory, Ningxia Medical University, Yinchuan, China.
Department of Neurosurgery, General Hospital of Ningxia Medical University, Yinchuan, China.

Classifications MeSH