Inhibition of K
KCa2 channel inhibitor
Kv11.1 blockers
SK channel
SK channel inhibitor
antiarrhythmic drug
arrhythmia
dofetilide
hypokalemia
Journal
Frontiers in pharmacology
ISSN: 1663-9812
Titre abrégé: Front Pharmacol
Pays: Switzerland
ID NLM: 101548923
Informations de publication
Date de publication:
2020
2020
Historique:
received:
26
02
2020
accepted:
06
05
2020
entrez:
9
6
2020
pubmed:
9
6
2020
medline:
9
6
2020
Statut:
epublish
Résumé
Hypokalemia reduces the cardiac repolarization reserve. This prolongs the QT-interval and increases the risk of ventricular arrhythmia; a risk that is exacerbated by administration of classical class 3 anti-arrhythmic agents.Small conductance Ca To study the effects of pharmacological K The current at +10 mV was compared in HEK293 cells stably expressing K Hypokalemia slightly increased K Hypokalemia was associated with an increased incidence of VF, an effect that also seen in the presence of dofetilide. In comparison, the structurally and functionally different K
Sections du résumé
BACKGROUND
BACKGROUND
Hypokalemia reduces the cardiac repolarization reserve. This prolongs the QT-interval and increases the risk of ventricular arrhythmia; a risk that is exacerbated by administration of classical class 3 anti-arrhythmic agents.Small conductance Ca
PURPOSE
OBJECTIVE
To study the effects of pharmacological K
METHODS
METHODS
The current at +10 mV was compared in HEK293 cells stably expressing K
RESULTS
RESULTS
Hypokalemia slightly increased K
CONCLUSION
CONCLUSIONS
Hypokalemia was associated with an increased incidence of VF, an effect that also seen in the presence of dofetilide. In comparison, the structurally and functionally different K
Identifiants
pubmed: 32508659
doi: 10.3389/fphar.2020.00749
pmc: PMC7251152
doi:
Types de publication
Journal Article
Langues
eng
Pagination
749Informations de copyright
Copyright © 2020 Diness, Abildgaard, Bomholtz, Skarsfeldt, Edvardsson, Sørensen, Grunnet and Bentzen.
Références
Cardiovasc Res. 2014 Jul 1;103(1):156-67
pubmed: 24817686
J Am Heart Assoc. 2013 Jan 03;2(1):e004713
pubmed: 23525437
Pflugers Arch. 1992 Feb;420(2):180-6
pubmed: 1620577
Circ Res. 2011 Apr 15;108(8):971-9
pubmed: 21350217
Annu Rev Physiol. 1997;59:171-91
pubmed: 9074760
Circ Arrhythm Electrophysiol. 2017 Oct;10(10):
pubmed: 29018164
Am J Physiol Heart Circ Physiol. 2012 Mar 1;302(5):H1023-30
pubmed: 22159993
Cardiovasc Res. 2003 Apr 1;58(1):32-45
pubmed: 12667944
J Pharmacol Toxicol Methods. 2014 Jan-Feb;69(1):61-101
pubmed: 23689033
Circulation. 2015 Oct 20;132(16):1528-1537
pubmed: 26269574
J Cardiovasc Pharmacol. 2015 Sep;66(3):294-9
pubmed: 25978690
Heart Rhythm. 2013 Oct;10(10):1516-24
pubmed: 23835258
Cardiovasc Res. 1995 Jul;30(1):31-8
pubmed: 7553721
Circ Arrhythm Electrophysiol. 2017 Mar;10(3):
pubmed: 28314851
Circ Res. 2020 Mar 27;126(7):889-906
pubmed: 32070187
Exp Physiol. 2009 Apr;94(4):434-46
pubmed: 19151074
Am J Med. 2015 Jan;128(1):60-7.e1
pubmed: 25107385
Front Pharmacol. 2020 Feb 28;11:159
pubmed: 32180722
Acta Physiol (Oxf). 2009 Dec;197(4):273-87
pubmed: 19656123
Front Pharmacol. 2019 Jun 19;10:668
pubmed: 31275147
Heart Rhythm. 2015 Apr;12(4):825-35
pubmed: 25542425
Pflugers Arch. 2017 Jun;469(5-6):739-750
pubmed: 28285409
Biophys J. 2001 May;80(5):2207-15
pubmed: 11325723
J Physiol. 2015 Mar 15;593(6):1509-21
pubmed: 25772299
Br Heart J. 1984 Feb;51(2):157-62
pubmed: 6197982
Circ Arrhythm Electrophysiol. 2010 Aug;3(4):380-90
pubmed: 20562443
PLoS One. 2014 Oct 01;9(10):e108824
pubmed: 25271970
Circulation. 2015 Oct 13;132(15):1377-86
pubmed: 26362634
Am J Physiol Heart Circ Physiol. 2013 Jan 1;304(1):H118-30
pubmed: 23086994
Circulation. 2014 Jan 28;129(4):430-40
pubmed: 24190961
Circ Res. 1997 Jun;80(6):782-9
pubmed: 9168780