Aerobic Exercise Training in Patients With mtDNA-Related Mitochondrial Myopathy.
mitochondrial DNA
mitochondrial myopathies
oxidative capacity
training
treatment
Journal
Frontiers in physiology
ISSN: 1664-042X
Titre abrégé: Front Physiol
Pays: Switzerland
ID NLM: 101549006
Informations de publication
Date de publication:
2020
2020
Historique:
received:
05
11
2019
accepted:
26
03
2020
entrez:
9
6
2020
pubmed:
9
6
2020
medline:
9
6
2020
Statut:
epublish
Résumé
In patients with mitochondrial DNA (mtDNA) mutation, a pathogenic mtDNA mutation is heteroplasmically distributed among tissues. The ratio between wild-type and mutated mtDNA copies determines the mtDNA mutation load of the tissue, which correlates inversively with oxidative capacity of the tissue. In patients with mtDNA mutation, the mutation load is often very high in skeletal muscle compared to other tissues. Additionally, skeletal muscle can increase its oxygen demand up to 100-fold from rest to exercise, which is unmatched by any other tissue. Thus, exercise intolerance is the most common symptom in patients with mtDNA mutation. The impaired oxidative capacity in skeletal muscle in patients with mtDNA mutation results in limitation in physical capacity that interferes with daily activities and impairs quality of life. Additionally, patients with mitochondrial disease due to mtDNA mutation often live a sedentary lifestyle, which further impair oxidative capacity and exercise tolerance. Since aerobic exercise training increase mitochondrial function and volume density in healthy individuals, studies have investigated if aerobic training could be used to counteract the progressive exercise intolerance in patients with mtDNA mutation. Overall studies investigating the effect of aerobic training in patients with mtDNA mutation have shown that aerobic training is an efficient way to improve oxidative capacity in this condition, and aerobic training seems to be safe even for patients with high mtDNA mutation in skeletal muscle.
Identifiants
pubmed: 32508662
doi: 10.3389/fphys.2020.00349
pmc: PMC7253634
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
349Informations de copyright
Copyright © 2020 Jeppesen.
Références
Cells. 2019 Mar 12;8(3):
pubmed: 30871120
J Hypertens. 2013 Apr;31(4):639-48
pubmed: 23325392
Neurology. 2007 Jan 2;68(1):59-61
pubmed: 17200494
Hum Mol Genet. 1996 Nov;5(11):1835-40
pubmed: 8923013
J Clin Invest. 1958 Apr;37(4):538-47
pubmed: 13539193
Am J Physiol Endocrinol Metab. 2001 Feb;280(2):E301-7
pubmed: 11158934
Brain. 2006 Dec;129(Pt 12):3402-12
pubmed: 16815877
J Appl Physiol. 1975 Nov;39(5):697-701
pubmed: 1184506
Med Sci Sports Exerc. 1992 Jan;24(1):30-7
pubmed: 1548993
Mol Genet Metab. 2003 Nov;80(3):321-9
pubmed: 14680979
J Appl Physiol (1985). 2016 Sep 1;121(3):699-708
pubmed: 27445303
J Physiol. 2012 Jul 15;590(14):3349-60
pubmed: 22586215
J Clin Invest. 1989 Jul;84(1):155-61
pubmed: 2544623
J Neurol Neurosurg Psychiatry. 1964 Oct;27:361-80
pubmed: 14213465
Am J Hum Genet. 1997 Feb;60(2):373-80
pubmed: 9012410
Ann Neurol. 2002 Jan;51(1):38-44
pubmed: 11782982
Biochem Biophys Res Commun. 1995 Aug 15;213(2):432-8
pubmed: 7646496
Acta Physiol Scand. 1997 Dec;161(4):459-64
pubmed: 9429652
Acta Med Scand Suppl. 1986;711:11-24
pubmed: 3535402
Am J Hum Genet. 1992 Apr;50(4):852-8
pubmed: 1550128
Med Sci Sports Exerc. 2005 Dec;37(12):2094-101
pubmed: 16331135
J Clin Invest. 1998 Apr 15;101(8):1654-60
pubmed: 9541495
Ann Neurol. 2001 Aug;50(2):133-41
pubmed: 11506394
Ciba Found Symp. 1981;82:41-58
pubmed: 6913477
J Med Genet. 2006 Aug;43(8):671-7
pubmed: 16490799
J Appl Physiol Respir Environ Exerc Physiol. 1979 Feb;46(2):322-5
pubmed: 422448
J Intern Med. 1991 Feb;229(2):125-30
pubmed: 1997637
Fed Proc. 1985 Apr;44(7):2260-70
pubmed: 3920083
Clin J Am Soc Nephrol. 2010 Jun;5(6):996-1002
pubmed: 20498251
Brain. 2003 Feb;126(Pt 2):413-23
pubmed: 12538407
Am J Physiol Endocrinol Metab. 2003 Jan;284(1):E193-205
pubmed: 12388120
J Gerontol A Biol Sci Med Sci. 2006 Jun;61(6):534-40
pubmed: 16799133
Am J Physiol Regul Integr Comp Physiol. 2011 Oct;301(4):R873-84
pubmed: 21813873
Brain. 2008 Nov;131(Pt 11):2824-31
pubmed: 18776212
Muscle Nerve. 1996 Apr;19(4):456-62
pubmed: 8622724
Neuromuscul Disord. 2000 Jan;10(1):40-5
pubmed: 10677862
J Endocrinol. 2017 Sep;234(3):R159-R181
pubmed: 28778962
Arch Neurol. 2009 Mar;66(3):365-70
pubmed: 19273755
Neurology. 1998 Apr;50(4):1055-60
pubmed: 9566394
Adv Exp Med Biol. 1988;227:257-76
pubmed: 3289319
J Physiol. 2010 Dec 1;588(Pt 23):4795-810
pubmed: 20921196
News Physiol Sci. 1988 Jun;3:100-2
pubmed: 11538851
Brain. 2006 Dec;129(Pt 12):3391-401
pubmed: 17085458
Neuromuscul Disord. 2012 Dec;22 Suppl 3:S172-7
pubmed: 23182634
Proc Natl Acad Sci U S A. 1989 Mar;86(5):1583-7
pubmed: 2922400
Med Sci Sports Exerc. 1982;14(5):339-43
pubmed: 7154888
J Physiol. 1985 Sep;366:233-49
pubmed: 4057091
Mitochondrion. 2009 Apr;9(2):144-8
pubmed: 19460295
Med Sci Sports Exerc. 2004 Jul;36(7):1196-201
pubmed: 15235325
Arch Neurol. 2006 Dec;63(12):1701-6
pubmed: 17172609
N Engl J Med. 1989 May 18;320(20):1293-9
pubmed: 2541333
Ann Neurol. 2003 Jul;54(1):86-92
pubmed: 12838523
Eur J Appl Physiol. 2003 Oct;90(3-4):420-9
pubmed: 12910345
Pediatr Res. 1990 Aug;28(2):131-6
pubmed: 2395603
Mol Cell Biochem. 1997 Sep;174(1-2):7-10
pubmed: 9309658
J Neurol Sci. 1998 Aug 14;159(2):176-80
pubmed: 9741404
Am J Hum Genet. 1999 Apr;64(4):1158-65
pubmed: 10090901
J Exp Biol. 1998 Apr;201(Pt 8):1051-64
pubmed: 9510519
Med Sci Sports. 1975 Fall;7(3):155-64
pubmed: 173969
J Biol Chem. 1967 May 10;242(9):2278-82
pubmed: 4290225
Biochim Biophys Acta. 2009 Aug;1792(8):783-90
pubmed: 19477272
Mol Neurobiol. 2010 Jun;41(2-3):256-66
pubmed: 20411357
Exp Physiol. 2013 Apr;98(4):883-98
pubmed: 23204290
Med Sci Sports Exerc. 1984 Oct;16(5):456-9
pubmed: 6595492
J Appl Physiol (1985). 2011 Mar;110(3):834-45
pubmed: 21030665
Mitochondrion. 2012 May;12(3):414-22
pubmed: 22155147
Mol Metab. 2016 Jul 01;5(8):635-645
pubmed: 27656401
Am J Respir Crit Care Med. 2001 Aug 1;164(3):425-32
pubmed: 11500344
Muscle Nerve. 1999 Sep;22(9):1239-43
pubmed: 10454720
Eur J Neurol. 2009 Dec;16(12):1336-9
pubmed: 19486129
Med Sci Sports Exerc. 2003 Jan;35(1):95-104
pubmed: 12544642
Neuromuscul Disord. 2013 Aug;23(8):629-36
pubmed: 23838278
J Appl Physiol (1985). 2013 Sep;115(6):785-93
pubmed: 23788574
Am J Physiol Endocrinol Metab. 2007 Sep;293(3):E672-80
pubmed: 17551003
Fed Proc. 1985 Apr;44(7):2293-300
pubmed: 3920084
Neurology. 1997 Sep;49(3):837-41
pubmed: 9305350
Ann Neurol. 1994 Dec;36(6):830-7
pubmed: 7998768
Eur J Appl Physiol Occup Physiol. 1983;50(3):383-92
pubmed: 6683162
Eur J Appl Physiol Occup Physiol. 1977 Mar 15;36(3):151-69
pubmed: 323004
Trans Am Neurol Assoc. 1978;103:6-10
pubmed: 757091
J Physiol. 1993 Sep;469:459-78
pubmed: 8271208
PLoS Med. 2007 Mar;4(3):e76
pubmed: 17341128
Am J Physiol Regul Integr Comp Physiol. 2007 Mar;292(3):R1271-8
pubmed: 17095651
Am J Clin Nutr. 1993 May;57(5 Suppl):752S-757S; discussion 757S-758S
pubmed: 8475892
Muscle Nerve. 2005 Sep;32(3):342-50
pubmed: 15962332
Am J Physiol Regul Integr Comp Physiol. 2000 Sep;279(3):R899-906
pubmed: 10956247
J Biol Chem. 2003 Dec 26;278(52):52873-80
pubmed: 14561769
Neurology. 1996 Aug;47(2):529-34
pubmed: 8757032