Cardiomyocyte Senescence and Cellular Communications Within Myocardial Microenvironments.
cardiomyocytes
inflammation
metabolism
microenvironment
senescence
Journal
Frontiers in endocrinology
ISSN: 1664-2392
Titre abrégé: Front Endocrinol (Lausanne)
Pays: Switzerland
ID NLM: 101555782
Informations de publication
Date de publication:
2020
2020
Historique:
received:
14
02
2020
accepted:
15
04
2020
entrez:
9
6
2020
pubmed:
9
6
2020
medline:
20
5
2021
Statut:
epublish
Résumé
Cardiovascular diseases have become the leading cause of human death. Aging is an independent risk factor for cardiovascular diseases. Cardiac aging is associated with maladaptation of cellular metabolism, dysfunction (or senescence) of cardiomyocytes, a decrease in angiogenesis, and an increase in tissue scarring (fibrosis). These events eventually lead to cardiac remodeling and failure. Senescent cardiomyocytes show the hallmarks of DNA damage, endoplasmic reticulum stress, mitochondria dysfunction, contractile dysfunction, hypertrophic growth, and senescence-associated secreting phenotype (SASP). Metabolism within cardiomyocytes is essential not only to fuel the pump function of the heart but also to maintain the functional homeostasis and participate in the senescence of cardiomyocytes. The senescence of cardiomyocyte is also regulated by the non-myocytes (endothelial cells, fibroblasts, and immune cells) in the local microenvironment. On the other hand, the senescent cardiomyocytes alter their phenotypes and subsequently affect the non-myocytes in the local microenvironment and contribute to cardiac aging and pathological remodeling. In this review, we first summarized the hallmarks of the senescence of cardiomyocytes. Then, we discussed the metabolic switch within senescent cardiomyocytes and provided a discussion of the cellular communications between dysfunctional cardiomyocytes and non-myocytes in the local microenvironment. We also addressed the functions of metabolic regulators within non-myocytes in modulating myocardial microenvironment. Finally, we pointed out some interesting and important questions that are needed to be addressed by further studies.
Identifiants
pubmed: 32508749
doi: 10.3389/fendo.2020.00280
pmc: PMC7253644
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
280Informations de copyright
Copyright © 2020 Tang, Li and Chen.
Références
ESC Heart Fail. 2020 Feb;7(1):284-288
pubmed: 31981320
J Biol Chem. 2010 Mar 5;285(10):7097-110
pubmed: 20042607
Circulation. 2018 Jun 12;137(24):2551-2553
pubmed: 29643058
Nat Rev Cardiol. 2019 Jun;16(6):361-378
pubmed: 30683889
Sci Transl Med. 2019 Sep 25;11(511):
pubmed: 31554736
Nat Rev Cardiol. 2018 Aug;15(8):445-456
pubmed: 29748594
Circulation. 2016 Feb 23;133(8):706-16
pubmed: 26819374
Front Immunol. 2014 Sep 02;5:420
pubmed: 25228902
J Mol Cell Cardiol. 2019 Feb;127:83-96
pubmed: 30529267
Basic Res Cardiol. 2016 Nov;111(6):63
pubmed: 27660282
Circ Res. 2011 Jul 22;109(3):272-80
pubmed: 21636802
Basic Res Cardiol. 2013 Mar;108(2):335
pubmed: 23381122
Basic Res Cardiol. 2013 Jul;108(4):357
pubmed: 23740215
Annu Rev Pathol. 2010;5:99-118
pubmed: 20078217
Cell. 2017 Apr 20;169(3):510-522.e20
pubmed: 28431249
Science. 2001 Mar 23;291(5512):2376-8
pubmed: 11269319
Atherosclerosis. 2010 Jul;211(1):1-8
pubmed: 20117784
Endocrinology. 2016 Jan;157(1):336-45
pubmed: 26469138
Circulation. 2019 Mar 19;139(12):1530-1547
pubmed: 30586758
Circulation. 2017 Nov 21;136(21):2051-2067
pubmed: 28947430
Life Sci. 2020 Feb 1;242:117158
pubmed: 31837328
Circulation. 2008 Mar 4;117(9):1172-82
pubmed: 18285568
PLoS One. 2018 Jan 18;13(1):e0190935
pubmed: 29346407
Circ Res. 2010 Jan 8;106(1):47-57
pubmed: 20056945
Proc Natl Acad Sci U S A. 2015 Jun 9;112(23):7249-54
pubmed: 25941360
Trends Cell Biol. 2018 Jun;28(6):436-453
pubmed: 29477613
Nat Rev Cardiol. 2018 Sep;15(9):543-554
pubmed: 30042431
J Endocrinol. 2009 Jun;201(3):419-27
pubmed: 19342398
Nature. 2017 Dec 7;552(7683):110-115
pubmed: 29160304
Front Physiol. 2014 May 06;5:175
pubmed: 24834056
J Am Coll Cardiol. 2019 Jan 22;73(2):190-209
pubmed: 30654892
Front Endocrinol (Lausanne). 2018 Dec 06;9:748
pubmed: 30574122
Circ Res. 2015 Jun 19;117(1):89-98
pubmed: 26089366
Int J Cardiol. 2018 Dec 1;272:194-201
pubmed: 30173922
J Mol Cell Cardiol. 2015 Mar;80:101-9
pubmed: 25584774
J Clin Invest. 2014 May;124(5):2136-46
pubmed: 24743145
Sci Signal. 2018 Nov 13;11(556):
pubmed: 30425165
Cardiovasc Res. 2010 Jul 1;87(1):127-36
pubmed: 20164120
Front Cardiovasc Med. 2018 Jul 26;5:101
pubmed: 30175102
PLoS One. 2012;7(3):e32765
pubmed: 22427880
IUBMB Life. 2012 Mar;64(3):231-41
pubmed: 22279035
J Genet Genomics. 2018 Jan 20;45(1):25-32
pubmed: 29396144
Physiol Rep. 2017 Nov;5(20):
pubmed: 29084842
J Am Heart Assoc. 2018 Sep 18;7(18):e009111
pubmed: 30371213
Mol Cell Biol. 2017 Mar 1;37(6):
pubmed: 28031326
Aging Dis. 2011 Apr;2(2):158-173
pubmed: 21837283
Nat Rev Cardiol. 2018 Sep;15(9):523-542
pubmed: 30054574
Cell Metab. 2017 Jun 6;25(6):1282-1293.e7
pubmed: 28416194
Circ Res. 2016 Jul 8;119(2):197-209
pubmed: 27217398
J Am Heart Assoc. 2017 Oct 24;6(10):
pubmed: 29066441
Aging Cell. 2016 Oct;15(5):973-7
pubmed: 26864908
Clin Sci (Lond). 2017 Jul 24;131(16):2063-2078
pubmed: 28739840
Annu Rev Physiol. 2013;75:49-67
pubmed: 23020580
Circ Res. 2016 Jan 22;118(2):279-95
pubmed: 26838314
Arterioscler Thromb Vasc Biol. 2016 Jan;36(1):145-55
pubmed: 26586663
Nat Commun. 2018 Jun 26;9(1):2432
pubmed: 29946151
Lancet. 2014 May 31;383(9932):1933-43
pubmed: 24831770
J Physiol. 2016 Apr 15;594(8):2061-73
pubmed: 26391109
Biochim Biophys Acta Mol Basis Dis. 2018 Oct;1864(10):3339-3352
pubmed: 30031229
J Mol Cell Cardiol. 2015 Apr;81:12-4
pubmed: 25647277
Eur Heart J. 2017 May 7;38(18):1389-1398
pubmed: 27099261
Immunol Cell Biol. 2014 Apr;92(4):340-5
pubmed: 24638063
Circulation. 2019 May 21;139(21):2495-2498
pubmed: 31107624
Exp Gerontol. 2019 May;119:120-127
pubmed: 30639303
Circ Res. 2008 Mar 28;102(6):703-10
pubmed: 18239138
Circ Res. 2019 Jan 18;124(2):263-278
pubmed: 30582448
Nat Commun. 2019 Mar 21;10(1):1307
pubmed: 30898999
J Cell Biochem. 2014 Apr;115(4):785-93
pubmed: 24255018
Circulation. 2012 Oct 2;126(14):1705-16
pubmed: 22932257
Cell Stem Cell. 2017 Feb 2;20(2):218-232.e5
pubmed: 27867037
Arterioscler Thromb Vasc Biol. 2013 May;33(5):894-902
pubmed: 23471235
Nat Med. 2012 Nov;18(11):1643-50
pubmed: 23086477
Aging Cell. 2010 Aug;9(4):592-606
pubmed: 20477759
Nat Rev Cardiol. 2019 Aug;16(8):491-502
pubmed: 30867577
Sci Rep. 2016 Nov 07;6:36576
pubmed: 27819261
Trends Cardiovasc Med. 2017 Aug;27(6):383-393
pubmed: 28438397
Biochim Biophys Acta. 2016 Jan;1863(1):128-38
pubmed: 26518453
J Clin Invest. 2015 Aug 3;125(8):2927-30
pubmed: 26214519
Biochim Biophys Acta Mol Basis Dis. 2018 Nov;1864(11):3639-3649
pubmed: 30251683
Circ Res. 2020 Feb 14;126(4):533-551
pubmed: 32078451
Int J Mol Sci. 2019 Jan 18;20(2):
pubmed: 30669312
Annu Rev Physiol. 2006;68:51-66
pubmed: 16460266
J Clin Invest. 2014 Mar;124(3):1382-92
pubmed: 24569380
Am J Physiol Cell Physiol. 2008 Jun;294(6):C1509-20
pubmed: 18367586
Nat Commun. 2016 Nov 24;7:13344
pubmed: 27882934
Nat Med. 2019 Nov;25(11):1667-1679
pubmed: 31700182
Aging Cell. 2005 Feb;4(1):21-30
pubmed: 15659210
Nat Commun. 2016 Mar 29;7:11074
pubmed: 27020607
Transl Res. 2019 Jun;208:1-14
pubmed: 30738862
J Mol Cell Cardiol. 2000 Nov;32(11):2075-82
pubmed: 11040110
JCI Insight. 2017 Sep 7;2(17):
pubmed: 28878126
Circulation. 2019 May 28;139(22):2585-2587
pubmed: 31136219
Sci Rep. 2017 Jul 25;7(1):6444
pubmed: 28744004
JACC Basic Transl Sci. 2019 Apr 29;4(2):200-203
pubmed: 31061922
Nat Med. 2007 Aug;13(8):952-61
pubmed: 17660828
Basic Res Cardiol. 2017 Jan;112(1):6
pubmed: 28000001
Arterioscler Thromb Vasc Biol. 2013 Dec;33(12):2830-8
pubmed: 24115032
Circ Res. 2013 Aug 16;113(5):603-16
pubmed: 23948585
Nat Commun. 2017 Mar 06;8:14680
pubmed: 28262700
Hypertension. 2015 Feb;65(2):328-34
pubmed: 25403608
Cell Death Dis. 2018 Jan 23;9(2):82
pubmed: 29362483
J Mol Cell Cardiol. 2016 Jan;90:84-93
pubmed: 26705059
Aging Cell. 2008 Mar;7(2):125-36
pubmed: 18031568
J Am Coll Cardiol. 2012 Jan 24;59(4):420-9
pubmed: 22261166
J Mol Cell Cardiol. 2015 Dec;89(Pt B):268-79
pubmed: 26497614
Circulation. 2018 Sep 18;138(12):1236-1252
pubmed: 29653926
Nature. 2009 Jul 2;460(7251):103-7
pubmed: 19494812
Am J Physiol Cell Physiol. 2020 Feb 1;318(2):C380-C391
pubmed: 31913702
Adv Exp Med Biol. 2018;1086:55-75
pubmed: 30232752
Oxid Med Cell Longev. 2017;2017:4175353
pubmed: 29201272
Circ Res. 2018 Sep 14;123(7):868-885
pubmed: 30355082
Circulation. 2009 Jun 9;119(22):2904-12
pubmed: 19470887
FASEB J. 2006 May;20(7):1024-6
pubmed: 16585059
J Histochem Cytochem. 2006 May;54(5):515-23
pubmed: 16344327
Circ Res. 2015 Mar 27;116(7):1231-44
pubmed: 25814684
J Mol Cell Cardiol. 2014 Sep;74:139-50
pubmed: 24825548
Biochem Pharmacol. 2018 Jun;152:362-372
pubmed: 29674003
Int J Cardiol. 2017 Feb 1;228:543-552
pubmed: 27875732
Nat Commun. 2013;4:2308
pubmed: 23917356
Nat Commun. 2018 Jan 25;9(1):374
pubmed: 29371602
Clin Sci (Lond). 2020 Mar 27;134(6):657-676
pubmed: 32219347
Nat Rev Mol Cell Biol. 2018 Feb;19(2):121-135
pubmed: 28974774
Nat Rev Genet. 2019 May;20(5):299-309
pubmed: 30760854
Arch Biochem Biophys. 2019 Feb 15;662:143-150
pubmed: 30543786
Gastroenterology. 2019 Sep;157(3):777-792.e14
pubmed: 31078624
Mol Metab. 2014 Aug 13;3(7):754-69
pubmed: 25353003
Circulation. 2014 Apr 1;129(13):1428-39
pubmed: 24637557
Circulation. 2016 Feb 23;133(8):698-705
pubmed: 26819376
J Clin Invest. 1996 Aug 15;98(4):930-6
pubmed: 8770864
Acta Pharmacol Sin. 2017 Dec;38(12):1589-1600
pubmed: 28748915
J Physiol. 2019 Feb 28;:
pubmed: 30816576
Circ Res. 2016 Oct 28;119(10):1049-1051
pubmed: 27789580
J Cell Mol Med. 2015 Sep;19(9):2153-61
pubmed: 25824442
Theranostics. 2018 Apr 3;8(9):2565-2582
pubmed: 29721099
J Gerontol A Biol Sci Med Sci. 2007 Dec;62(12):1326-36
pubmed: 18166682
Transl Res. 2014 Oct;164(4):323-35
pubmed: 24880146
J Mol Cell Cardiol. 2013 Oct;63:26-36
pubmed: 23871790
J Exp Med. 2016 Jun 27;213(7):1353-74
pubmed: 27353089
Aging Cell. 2019 Jun;18(3):e12945
pubmed: 30920115
EMBO J. 2019 Mar 1;38(5):
pubmed: 30737259