Impact of Acute and Chronic Amyloid-β Peptide Exposure on Gut Microbial Commensals in the Mouse.
5xFAD
Alzheimer’s disease
Amyloid-β peptide
anti-microbial
microbiome
mouse model
Journal
Frontiers in microbiology
ISSN: 1664-302X
Titre abrégé: Front Microbiol
Pays: Switzerland
ID NLM: 101548977
Informations de publication
Date de publication:
2020
2020
Historique:
received:
17
02
2020
accepted:
24
04
2020
entrez:
9
6
2020
pubmed:
9
6
2020
medline:
9
6
2020
Statut:
epublish
Résumé
Alzheimer's disease (AD) is the most common form of dementia. Besides its cognitive phenotype, AD leads to crucial changes in gut microbiome composition in model mice and in patients, but the reported data are still highly inconsistent. Therefore, we investigated chronic effects of AD-characteristic neurotoxic amyloid-β (Aβ) peptides as provided by transgenic overexpression (5xFAD mouse model) and acute effects due to oral application of Aβ on gut microbes. Astonishingly, one-time feeding of wild type mice with Aβ
Identifiants
pubmed: 32508799
doi: 10.3389/fmicb.2020.01008
pmc: PMC7251927
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1008Informations de copyright
Copyright © 2020 dos Santos Guilherme, Todorov, Osterhof, Möllerke, Cub, Hankeln, Gerber and Endres.
Références
Sci Rep. 2017 Oct 19;7(1):13537
pubmed: 29051531
Cell. 2016 Jun 16;165(7):1762-1775
pubmed: 27315483
Diabetes. 2008 Jun;57(6):1470-81
pubmed: 18305141
Magn Reson Med. 2002 Aug;48(2):255-61
pubmed: 12210933
J Nutr Health Aging. 2012 Mar;16(3):231-6
pubmed: 22456778
Cell. 2016 Dec 1;167(6):1469-1480.e12
pubmed: 27912057
Nat Rev Neurosci. 2011 Jul 13;12(8):453-66
pubmed: 21750565
J Alzheimers Dis. 2017;60(4):1241-1257
pubmed: 29036812
J Alzheimers Dis. 2017;56(1):385-390
pubmed: 27911317
Neurobiol Dis. 2012 Jun;46(3):559-64
pubmed: 22048068
Parkinsonism Relat Disord. 2016 Nov;32:66-72
pubmed: 27591074
Genome Med. 2017 Nov 28;9(1):103
pubmed: 29183332
Nature. 2006 Dec 21;444(7122):1027-31
pubmed: 17183312
Mov Disord. 2012 May;27(6):716-9
pubmed: 22550057
Arch Neurol. 2005 Oct;62(10):1556-60
pubmed: 16216938
Eur J Neurol. 2018 Jan;25(1):59-70
pubmed: 28872215
Alzheimers Dement. 2018 Dec;14(12):1602-1614
pubmed: 30314800
Front Immunol. 2017 Jun 30;8:754
pubmed: 28713378
Nat Methods. 2016 Jul;13(7):581-3
pubmed: 27214047
Proc Natl Acad Sci U S A. 2019 Jun 25;116(26):12672-12677
pubmed: 31182571
Microbiome. 2017 Mar 3;5(1):27
pubmed: 28253908
Brain Behav Immun. 2007 Aug;21(6):727-35
pubmed: 17604598
Curr Alzheimer Res. 2019;16(5):405-417
pubmed: 30907321
Genome Biol. 2014;15(12):550
pubmed: 25516281
Sci Rep. 2016 Sep 14;6:32228
pubmed: 27624303
Sci Transl Med. 2016 May 25;8(340):340ra72
pubmed: 27225182
J Alzheimers Dis. 2018;63(4):1337-1346
pubmed: 29758946
Science. 1992 Apr 10;256(5054):184-5
pubmed: 1566067
Science. 1982 Mar 5;215(4537):1237-9
pubmed: 7058341
Prog Neurobiol. 2006 Jun;79(2):95-111
pubmed: 16904810
Mol Pharm. 2012 Apr 2;9(4):708-17
pubmed: 22081976
Lett Appl Microbiol. 2018 Jun;66(6):464-471
pubmed: 29575030
Nat Med. 2003 Jan;9(1):3-4
pubmed: 12514700
Front Mol Neurosci. 2017 Mar 17;10:56
pubmed: 28367112
Neurobiol Aging. 2017 Jan;49:60-68
pubmed: 27776263
Front Neurosci. 2019 Mar 05;13:113
pubmed: 30890906
Curr Neurol Neurosci Rep. 2017 Oct 17;17(12):94
pubmed: 29039142
Biol Sex Differ. 2018 Jun 18;9(1):26
pubmed: 29914546
Dement Geriatr Cogn Disord. 2005;20(2-3):192-7
pubmed: 16088144
Sci Rep. 2018 Jan 22;8(1):1329
pubmed: 29358714
Brain. 2017 May 1;140(5):1486-1498
pubmed: 28383676
Immunity. 2013 Aug 22;39(2):400-12
pubmed: 23973225
J Neurosci. 2006 Oct 4;26(40):10129-40
pubmed: 17021169
Aging (Albany NY). 2018 Dec 18;10(12):4054-4065
pubmed: 30562162
Gut. 2009 Aug;58(8):1091-103
pubmed: 19240062
Front Neurosci. 2018 Nov 13;12:830
pubmed: 30542257
Sci Rep. 2017 Feb 08;7:41802
pubmed: 28176819
Gut. 2011 May;60(5):631-7
pubmed: 21209126
Ann Neurol. 1987 Nov;22(5):639-43
pubmed: 3122646
Nature. 1989 Sep 21;341(6239):226-30
pubmed: 2528696
Eur J Neurol. 2008 Apr;15 Suppl 1:14-20
pubmed: 18353132
Nat Methods. 2010 May;7(5):335-6
pubmed: 20383131
Am J Pathol. 1989 Jun;134(6):1365-71
pubmed: 2502927
Arch Neurol. 2009 Mar;66(3):336-42
pubmed: 19273752
J Alzheimers Dis. 2017;56(2):775-788
pubmed: 28035935
PLoS One. 2010 Mar 03;5(3):e9505
pubmed: 20209079
Alzheimer Dis Assoc Disord. 2012 Apr-Jun;26(2):101-5
pubmed: 21666429
Aging (Albany NY). 2018 Jun 10;10(6):1257-1267
pubmed: 29886457