Klotho Alleviates Lung Injury Caused by Paraquat via Suppressing ROS/P38 MAPK-Regulated Inflammatory Responses and Apoptosis.
A549 Cells
Acute Lung Injury
/ metabolism
Aging
/ physiology
Animals
Apoptosis
Disease Models, Animal
Glucuronidase
/ metabolism
Humans
Interleukin-1beta
/ metabolism
Interleukin-6
/ metabolism
Klotho Proteins
Lipid Peroxidation
Male
Membrane Potential, Mitochondrial
Mice
Mice, Inbred C57BL
Paraquat
Signal Transduction
p38 Mitogen-Activated Protein Kinases
/ metabolism
Journal
Oxidative medicine and cellular longevity
ISSN: 1942-0994
Titre abrégé: Oxid Med Cell Longev
Pays: United States
ID NLM: 101479826
Informations de publication
Date de publication:
2020
2020
Historique:
received:
15
02
2020
revised:
26
04
2020
accepted:
28
04
2020
entrez:
9
6
2020
pubmed:
9
6
2020
medline:
22
12
2020
Statut:
epublish
Résumé
Acute lung injury (ALI) induced by paraquat (PQ) progresses rapidly with high mortality; however, there is no effective treatment, and the specific mechanism is not well understood. The antiaging protein klotho (KL) has multiple functions and exerts significant influences on various pathophysiological processes. This work evaluated the impact of KL on PQ-induced ALI and investigated its underlying mechanisms. As for
Identifiants
pubmed: 32509139
doi: 10.1155/2020/1854206
pmc: PMC7244968
doi:
Substances chimiques
Interleukin-1beta
0
Interleukin-6
0
p38 Mitogen-Activated Protein Kinases
EC 2.7.11.24
Glucuronidase
EC 3.2.1.31
Klotho Proteins
EC 3.2.1.31
Paraquat
PLG39H7695
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1854206Informations de copyright
Copyright © 2020 Zhiqiang Zhang et al.
Déclaration de conflit d'intérêts
The authors declare that they have no conflicts of interest.
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