Emerging roles of ATG proteins and membrane lipids in autophagosome formation.
Endoplasmic reticulum
Macroautophagy
Journal
Cell discovery
ISSN: 2056-5968
Titre abrégé: Cell Discov
Pays: England
ID NLM: 101661034
Informations de publication
Date de publication:
2020
2020
Historique:
received:
03
12
2019
accepted:
21
03
2020
entrez:
9
6
2020
pubmed:
9
6
2020
medline:
9
6
2020
Statut:
epublish
Résumé
Autophagosome biogenesis is a dynamic membrane event, which is executed by the sequential function of autophagy-related (ATG) proteins. Upon autophagy induction, a cup-shaped membrane structure appears in the cytoplasm, then elongates sequestering cytoplasmic materials, and finally forms a closed double membrane autophagosome. However, how this complex vesicle formation event is strictly controlled and achieved is still enigmatic. Recently, there is accumulating evidence showing that some ATG proteins have the ability to directly interact with membranes, transfer lipids between membranes and regulate lipid metabolism. A novel role for various membrane lipids in autophagosome formation is also emerging. Here, we highlight past and recent key findings on the function of ATG proteins related to autophagosome biogenesis and consider how ATG proteins control this dynamic membrane formation event to organize the autophagosome by collaborating with membrane lipids.
Identifiants
pubmed: 32509328
doi: 10.1038/s41421-020-0161-3
pii: 161
pmc: PMC7248066
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
32Subventions
Organisme : Cancer Research UK
ID : FC001187
Pays : United Kingdom
Organisme : Arthritis Research UK
ID : FC001187
Pays : United Kingdom
Informations de copyright
© The Author(s) 2020.
Déclaration de conflit d'intérêts
Conflict of interestThe authors declare that they have no conflict of interest.
Références
J Cell Sci. 2006 Sep 15;119(Pt 18):3888-900
pubmed: 16940348
Nature. 2008 Nov 13;456(7219):264-8
pubmed: 18849965
EMBO Rep. 2018 Apr;19(4):
pubmed: 29437695
Autophagy. 2020 Jun;16(6):1007-1020
pubmed: 31352862
J Biol Chem. 2007 Dec 28;282(52):37298-302
pubmed: 17986448
Proc Natl Acad Sci U S A. 2008 Dec 9;105(49):19211-6
pubmed: 19050071
Elife. 2019 Feb 27;8:
pubmed: 30810528
Mol Biol Cell. 2004 Aug;15(8):3553-66
pubmed: 15155809
FEBS Lett. 1993 Oct 25;333(1-2):169-74
pubmed: 8224160
Nat Commun. 2017 May 31;8:15637
pubmed: 28561066
EMBO J. 2017 Jul 14;36(14):2018-2033
pubmed: 28550152
Biochem Biophys Res Commun. 2011 Jul 15;410(4):786-91
pubmed: 21703229
Proc Natl Acad Sci U S A. 2013 Nov 26;110(48):19432-7
pubmed: 24218626
Mol Biol Cell. 2012 May;23(10):1860-73
pubmed: 22456507
EMBO J. 1995 Jul 17;14(14):3339-48
pubmed: 7628435
EMBO Rep. 2020 Mar 4;21(3):e48412
pubmed: 32009292
Nat Commun. 2014;5:3207
pubmed: 24492518
Nat Commun. 2018 Sep 27;9(1):3958
pubmed: 30262884
EMBO Rep. 2013 Mar 1;14(3):284-91
pubmed: 23392225
Traffic. 2013 Feb;14(2):233-46
pubmed: 23078654
Curr Biol. 2014 Mar 17;24(6):609-20
pubmed: 24613307
Traffic. 2014 Nov;15(11):1235-46
pubmed: 25131297
Autophagy. 2010 Aug;6(6):764-76
pubmed: 20639694
Mol Cell. 2017 Aug 3;67(3):528-534.e3
pubmed: 28757208
J Cell Biol. 1967 Nov;35(2):C11-6
pubmed: 6055998
Nat Commun. 2017 Mar 22;8:14846
pubmed: 28327644
Biochim Biophys Acta. 2016 Aug;1861(8 Pt B):952-961
pubmed: 26898182
Sci Rep. 2015 Oct 19;5:15213
pubmed: 26477494
EMBO J. 2010 Jan 6;29(1):27-40
pubmed: 19893488
J Biol Chem. 2004 Sep 3;279(36):37741-50
pubmed: 15194695
Autophagy. 2020 Mar;16(3):391-407
pubmed: 31142229
J Biol Chem. 2012 Sep 14;287(38):31681-90
pubmed: 22851171
EMBO J. 2012 Nov 14;31(22):4304-17
pubmed: 23064152
Mol Biol Cell. 2004 Jun;15(6):2652-63
pubmed: 15020712
Mol Cell Biol. 2014 May;34(9):1695-706
pubmed: 24591649
J Biol Chem. 2008 Jan 25;283(4):1921-8
pubmed: 18039664
EMBO J. 2004 May 5;23(9):1922-33
pubmed: 15103325
J Cell Biol. 2019 May 6;218(5):1634-1652
pubmed: 30917996
Nat Commun. 2014 May 22;5:3920
pubmed: 24849286
Nat Commun. 2016 Dec 22;7:13889
pubmed: 28004827
Cell. 2010 May 14;141(4):656-67
pubmed: 20478256
Nat Cell Biol. 2009 Dec;11(12):1433-7
pubmed: 19898463
J Biol Chem. 2000 Jan 14;275(2):992-8
pubmed: 10625637
Nature. 2004 Dec 23;432(7020):1032-6
pubmed: 15525940
Science. 2008 Jul 4;321(5885):117-20
pubmed: 18599786
Nat Struct Mol Biol. 2013 Jan;20(1):59-66
pubmed: 23202584
J Cell Sci. 2006 Jan 15;119(Pt 2):259-70
pubmed: 16390869
FEBS Lett. 2017 Dec;591(23):3819-3830
pubmed: 29113029
Cell Metab. 2009 Nov;10(5):430-5
pubmed: 19883620
J Biol Chem. 2004 Apr 30;279(18):18384-91
pubmed: 14970205
J Biol Chem. 2018 Apr 13;293(15):5386-5395
pubmed: 29371398
Annu Rev Cell Dev Biol. 2011;27:107-32
pubmed: 21801009
Proc Natl Acad Sci U S A. 2011 May 10;108(19):7769-74
pubmed: 21518905
J Biol Chem. 2006 Mar 31;281(13):8518-27
pubmed: 16415355
Proc Natl Acad Sci U S A. 2012 May 1;109(18):6981-6
pubmed: 22509044
J Biol Chem. 2014 Sep 19;289(38):26021-26037
pubmed: 25086043
J Biol Chem. 2008 Aug 29;283(35):23972-80
pubmed: 18586673
Elife. 2016 Nov 18;5:
pubmed: 27855785
J Biol Chem. 2012 Dec 28;287(53):44261-9
pubmed: 23129774
Mol Cell. 2014 Jul 17;55(2):238-52
pubmed: 24954904
Cell Death Dis. 2018 Jun 4;9(6):670
pubmed: 29867196
Proc Natl Acad Sci U S A. 2016 Jul 19;113(29):8224-9
pubmed: 27385829
Science. 1993 Apr 2;260(5104):88-91
pubmed: 8385367
Proc Natl Acad Sci U S A. 1978 Oct;75(10):5039-42
pubmed: 283412
EMBO J. 2017 Nov 15;36(22):3274-3291
pubmed: 29030482
J Biol Chem. 2008 Aug 8;283(32):21847-52
pubmed: 18544538
Autophagy. 2009 Nov;5(8):1180-5
pubmed: 19855179
Sci Rep. 2017 Oct 25;7(1):14008
pubmed: 29070817
Nat Commun. 2016 Aug 11;7:12420
pubmed: 27510922
J Cell Biol. 2010 Aug 23;190(4):511-21
pubmed: 20713597
Mol Cell. 2014 Feb 6;53(3):471-83
pubmed: 24440502
J Cell Biol. 2001 Feb 5;152(3):519-30
pubmed: 11157979
J Cell Biol. 2008 Aug 25;182(4):685-701
pubmed: 18725538
Mol Biol Cell. 2013 Sep;24(18):2918-31
pubmed: 23904270
Genes Cells. 2007 Feb;12(2):209-18
pubmed: 17295840
Autophagy. 2016 Nov;12(11):2129-2144
pubmed: 27630019
J Biol Chem. 2014 Aug 22;289(34):23938-50
pubmed: 25023287
Nature. 2000 Nov 23;408(6811):488-92
pubmed: 11100732
PLoS One. 2016 Nov 18;11(11):e0166499
pubmed: 27861594
Cell Res. 2017 Aug;27(8):989-1001
pubmed: 28731030
PLoS Comput Biol. 2017 Oct 24;13(10):e1005817
pubmed: 29065154
J Cell Biol. 2019 Jun 3;218(6):1787-1798
pubmed: 30952800
J Biol Chem. 2012 Nov 16;287(47):39275-90
pubmed: 23043107
J Cell Biol. 1995 Nov;131(3):591-602
pubmed: 7593182
Nat Commun. 2010;1:142
pubmed: 21266992
Autophagy. 2018;14(5):862-879
pubmed: 29164996
J Biol Chem. 2011 Dec 9;286(49):42534-42544
pubmed: 21859708
Nat Cell Biol. 2010 Aug;12(8):747-57
pubmed: 20639872
FEBS Lett. 2015 Mar 12;589(6):744-9
pubmed: 25680528
J Cell Biol. 2018 Oct 1;217(10):3625-3639
pubmed: 30093493
EMBO J. 2018 Feb 15;37(4):
pubmed: 29317426
Mol Biol Cell. 2008 Jul;19(7):2916-25
pubmed: 18448665
Mol Cell. 2019 Jan 17;73(2):339-353.e6
pubmed: 30581147
Biophys J. 2015 May 5;108(9):2223-34
pubmed: 25954880
Cell Death Dis. 2014 May 22;5:e1245
pubmed: 24853423
J Biol Chem. 2010 Apr 9;285(15):11476-88
pubmed: 20154084
J Pharmacol Exp Ther. 2011 Nov;339(2):487-98
pubmed: 21856859
EBioMedicine. 2018 Apr;30:261-272
pubmed: 29606629
Nat Rev Mol Cell Biol. 2009 Jul;10(7):458-67
pubmed: 19491929
J Biol Chem. 2009 Jan 30;284(5):2719-2728
pubmed: 19029119
Mol Cell. 2015 Oct 1;60(1):89-104
pubmed: 26431026
PLoS Genet. 2018 Apr 26;14(4):e1007363
pubmed: 29698489
Sci Rep. 2017 Nov 15;7(1):15614
pubmed: 29142222
Nature. 2006 Jun 15;441(7095):880-4
pubmed: 16625205
J Cell Sci. 2013 Nov 1;126(Pt 21):4963-73
pubmed: 23986483
FEBS Lett. 1994 Aug 1;349(2):275-80
pubmed: 8050581
Biol Open. 2017 Jan 15;6(1):35-40
pubmed: 27881438
Cell Res. 2017 Feb;27(2):184-201
pubmed: 27934868
EMBO J. 2019 Apr 15;38(8):e100312
pubmed: 31368593
FEBS Lett. 2015 Jan 16;589(2):269-76
pubmed: 25500271
EMBO J. 2016 Feb 1;35(3):281-301
pubmed: 26711178
Traffic. 2015 Feb;16(2):172-90
pubmed: 25385507
Nature. 2006 Jun 15;441(7095):885-9
pubmed: 16625204
Autophagy. 2020 Mar;16(3):575-583
pubmed: 31276439
Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):9800-5
pubmed: 23716696
Biochem J. 1998 Oct 15;335 ( Pt 2):217-24
pubmed: 9761717
PLoS Biol. 2019 Apr 1;17(4):e2007044
pubmed: 30933966
Nature. 2009 Apr 30;458(7242):1131-5
pubmed: 19339967
J Biol Chem. 2004 Sep 24;279(39):40584-92
pubmed: 15277523
Proc Natl Acad Sci U S A. 2012 Jul 24;109(30):E2042-9
pubmed: 22753491
Apoptosis. 2015 May;20(5):658-70
pubmed: 25682163
J Mol Biol. 2016 May 8;428(9 Pt A):1725-41
pubmed: 27059781
Proc Natl Acad Sci U S A. 2008 Nov 11;105(45):17402-7
pubmed: 18981422
Science. 2015 Oct 9;350(6257):aac7365
pubmed: 26450213
J Biol Chem. 2010 Dec 3;285(49):38568-79
pubmed: 20876532
Cell Death Differ. 2014 Jul;21(7):1132-41
pubmed: 24632948
FASEB J. 2017 Sep;31(9):3757-3773
pubmed: 28522593
Autophagy. 2009 Oct;5(7):980-90
pubmed: 19587536
J Biol Chem. 2012 May 11;287(20):16256-66
pubmed: 22437838
Mol Biol Cell. 2001 Nov;12(11):3690-702
pubmed: 11694599
Dev Cell. 2018 Apr 9;45(1):114-131.e8
pubmed: 29634932
Cell Death Differ. 2014 Apr;21(4):533-46
pubmed: 24317201
J Cell Sci. 2013 Nov 15;126(Pt 22):5224-38
pubmed: 24013547
J Cell Biol. 2010 Sep 20;190(6):1005-22
pubmed: 20855505
Oncotarget. 2016 Apr 12;7(15):20855-68
pubmed: 26980706
Proc Natl Acad Sci U S A. 2018 Oct 9;115(41):10363-10368
pubmed: 30254161
Proc Natl Acad Sci U S A. 2015 Jun 2;112(22):7015-20
pubmed: 26038556
Nat Cell Biol. 2019 Mar;21(3):372-383
pubmed: 30778222
EMBO Rep. 2018 Sep;19(9):
pubmed: 30126924
FEBS Lett. 2009 Apr 2;583(7):1078-83
pubmed: 19285500
Dev Cell. 2011 Aug 16;21(2):343-57
pubmed: 21802374
Nat Struct Mol Biol. 2013 Feb;20(2):144-9
pubmed: 23262492
Autophagy. 2010 May;6(4):506-22
pubmed: 20505359
EMBO J. 2015 Apr 15;34(8):1025-41
pubmed: 25586377
J Cell Sci. 2013 Jan 15;126(Pt 2):593-604
pubmed: 23230146
Nature. 2013 Mar 21;495(7441):389-93
pubmed: 23455425
J Biol Chem. 2012 Nov 16;287(47):39898-910
pubmed: 23035115
Ultramicroscopy. 2014 Aug;143:77-87
pubmed: 24238600
Annu Rev Cell Dev Biol. 2019 Oct 6;35:453-475
pubmed: 31283377
Nat Struct Mol Biol. 2019 Apr;26(4):281-288
pubmed: 30911189
Autophagy. 2017 May 4;13(5):885-899
pubmed: 28521611
J Cell Biol. 2016 Mar 14;212(6):621-31
pubmed: 26953354
Elife. 2013 Aug 06;2:e00947
pubmed: 23930225
Cell. 2012 Dec 21;151(7):1501-1512
pubmed: 23219485
Cancer Res. 2004 Jun 15;64(12):4286-93
pubmed: 15205343
Mol Biol Cell. 2008 Aug;19(8):3442-53
pubmed: 18550798
PLoS One. 2012;7(5):e36188
pubmed: 22563482
PLoS One. 2012;7(3):e32753
pubmed: 22427874
Nature. 2006 Feb 2;439(7076):604-7
pubmed: 16452979
EMBO J. 2019 May 2;38(9):
pubmed: 30936093
Elife. 2019 Jul 04;8:
pubmed: 31271352
Cell Death Differ. 2011 Feb;18(2):350-61
pubmed: 20798685
Proc Natl Acad Sci U S A. 1982 Mar;79(6):1889-92
pubmed: 6952238
J Biol Chem. 2012 Apr 27;287(18):14364-76
pubmed: 22408252
J Biol Chem. 2015 Mar 27;290(13):8146-53
pubmed: 25645919
Trends Biochem Sci. 2016 Nov;41(11):907-923
pubmed: 27595473
J Cell Biol. 1992 Oct;119(2):301-11
pubmed: 1400575
Mol Biol Cell. 2008 Dec;19(12):5360-72
pubmed: 18843052
Elife. 2019 Sep 17;8:
pubmed: 31526472
Elife. 2014 Dec 09;3:
pubmed: 25490155
Nat Struct Mol Biol. 2013 Apr;20(4):433-9
pubmed: 23503366
Proc Natl Acad Sci U S A. 2017 Dec 12;114(50):E10697-E10706
pubmed: 29180427
J Cell Biol. 2012 May 28;197(5):659-75
pubmed: 22613832
J Biol Chem. 2006 Feb 10;281(6):3017-24
pubmed: 16303767
Biochem J. 2014 Jul 15;461(2):315-22
pubmed: 24785657
EMBO J. 2015 Aug 13;34(16):2117-31
pubmed: 26162625
J Cell Biol. 2019 May 6;218(5):1503-1510
pubmed: 30787039
Cell. 2014 Jan 30;156(3):469-81
pubmed: 24485455
EMBO J. 2017 Jun 14;36(12):1719-1735
pubmed: 28495679
Nat Cell Biol. 2014 May;16(5):415-24
pubmed: 24747438
Cell Rep. 2019 Aug 13;28(7):1744-1757.e5
pubmed: 31412244
J Cell Biol. 2012 Jul 23;198(2):219-33
pubmed: 22826123
Mol Cell Biol. 2009 Jan;29(1):157-71
pubmed: 18936157
Nature. 1999 Dec 9;402(6762):672-6
pubmed: 10604474
Autophagy. 2019 Aug;15(8):1333-1355
pubmed: 30767700
J Biol Chem. 2012 Jun 15;287(25):21110-20
pubmed: 22556413
Mol Biol Cell. 2008 May;19(5):2092-100
pubmed: 18321988
Cell. 2010 Jun 11;141(6):1042-55
pubmed: 20550938
Proc Natl Acad Sci U S A. 2014 Sep 2;111(35):12793-8
pubmed: 25139988
J Cell Biol. 2018 Aug 6;217(8):2743-2763
pubmed: 29848619
EMBO J. 2001 Nov 1;20(21):5971-81
pubmed: 11689437
Mol Cell. 2012 Aug 10;47(3):339-48
pubmed: 22704557
Proc Natl Acad Sci U S A. 2018 Oct 16;115(42):E9792-E9801
pubmed: 30185561
J Biol Chem. 2012 Nov 2;287(45):37964-72
pubmed: 22977244
J Cell Sci. 2016 Oct 15;129(20):3781-3791
pubmed: 27587839
EMBO Rep. 2017 Sep;18(9):1586-1603
pubmed: 28754694
Science. 2012 Apr 27;336(6080):474-7
pubmed: 22539722
J Biol Chem. 2012 Aug 17;287(34):28503-7
pubmed: 22778255
Mol Biol Cell. 2018 May 15;29(10):1228-1237
pubmed: 29540529
Science. 2004 Nov 5;306(5698):1037-40
pubmed: 15528445
Curr Biol. 2018 Apr 23;28(8):1234-1245.e4
pubmed: 29628370
J Struct Biol. 2016 Oct;196(1):29-36
pubmed: 27251905
Cell Res. 2012 Mar;22(3):473-89
pubmed: 22310240
J Cell Biol. 2013 Oct 14;203(1):115-28
pubmed: 24100292
Eur J Biochem. 1997 Jan 15;243(1-2):240-6
pubmed: 9030745
Traffic. 2018 Aug;19(8):624-638
pubmed: 29761602
Nat Struct Mol Biol. 2014 Jun;21(6):513-21
pubmed: 24793651
Genes Cells. 2009 May;14(5):525-38
pubmed: 19371383
J Lipid Res. 2014 Dec;55(12):2521-31
pubmed: 25332431
EMBO J. 2015 Apr 1;34(7):955-73
pubmed: 25691244
Dev Cell. 2016 Jul 11;38(1):86-99
pubmed: 27404361
Proc Natl Acad Sci U S A. 2015 Mar 17;112(11):3350-5
pubmed: 25737544
Autophagy. 2016 May 3;12(5):833-49
pubmed: 27070082
EMBO Rep. 2014 Apr;15(4):392-401
pubmed: 24603492
J Cell Biol. 2013 Aug 19;202(4):685-98
pubmed: 23940117
J Cell Sci. 2013 Jun 1;126(Pt 11):2534-44
pubmed: 23549786
J Cell Biol. 2001 Feb 19;152(4):657-68
pubmed: 11266458
J Cell Biol. 1990 Sep;111(3):941-53
pubmed: 2391370
Nat Cell Biol. 2009 Apr;11(4):385-96
pubmed: 19270696
EMBO J. 2012 Sep 12;31(18):3691-703
pubmed: 22885598
Nat Rev Mol Cell Biol. 2013 Dec;14(12):759-74
pubmed: 24201109
Autophagy. 2013 Oct;9(10):1491-9
pubmed: 23884233
J Cell Biol. 2018 Nov 5;217(11):3817-3828
pubmed: 30093494
Mol Cell. 2017 Sep 21;67(6):974-989.e6
pubmed: 28890335
Nat Commun. 2016 Jan 12;7:10338
pubmed: 26753620
Am J Physiol Cell Physiol. 2009 Aug;297(2):C451-8
pubmed: 19474291
Science. 2010 Mar 26;327(5973):1638-42
pubmed: 20339072
Adv Cancer Res. 2018;140:27-60
pubmed: 30060813
J Cell Biol. 2013 Oct 28;203(2):299-313
pubmed: 24165940
Cell. 2013 Sep 12;154(6):1285-99
pubmed: 24034251
Cell Death Dis. 2016 Nov 3;7(11):e2448
pubmed: 27809301
Autophagy. 2017;13(11):1870-1883
pubmed: 28820312
J Cell Biol. 1990 Jun;110(6):1923-33
pubmed: 2351689
Mol Cell. 2017 Sep 21;67(6):907-921.e7
pubmed: 28844862