High expression of stromal signatures correlated with macrophage infiltration, angiogenesis and poor prognosis in glioma microenvironment.
Angiogenesis
Glioma
Macrophage
Stromal signature
Tumor microenvironment
Journal
PeerJ
ISSN: 2167-8359
Titre abrégé: PeerJ
Pays: United States
ID NLM: 101603425
Informations de publication
Date de publication:
2020
2020
Historique:
received:
10
12
2019
accepted:
01
04
2020
entrez:
9
6
2020
pubmed:
9
6
2020
medline:
9
6
2020
Statut:
epublish
Résumé
Glioma is one of the most fatal tumors in central nervous system. Previous studies gradually revealed the association between tumor microenvironment and the prognosis of gliomas patients. However, the correlation between tumor-infiltrating immune cell and stromal signatures are unknown. In our study, we obtained gliomas samples from the Chinese Glioma Genome Atlas (CGGA) and The Cancer Genome Atlas (TCGA). The landscape of tumor infiltrating immune cell subtypes in gliomas was calculated by CIBERSORT. As a result, we found high infiltration of macrophages was correlated with poor outcome (
Identifiants
pubmed: 32509446
doi: 10.7717/peerj.9038
pii: 9038
pmc: PMC7245335
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e9038Informations de copyright
© 2020 Tian et al.
Déclaration de conflit d'intérêts
The authors declare that they have no competing interests.
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