Respiratory Syncytial Virus's Non-structural Proteins: Masters of Interference.
antiviral pathway
innate immunity
mitochondria
nonstructural (NS) proteins
respiratory syncitial virus
Journal
Frontiers in cellular and infection microbiology
ISSN: 2235-2988
Titre abrégé: Front Cell Infect Microbiol
Pays: Switzerland
ID NLM: 101585359
Informations de publication
Date de publication:
2020
2020
Historique:
received:
25
02
2020
accepted:
22
04
2020
entrez:
9
6
2020
pubmed:
9
6
2020
medline:
18
5
2021
Statut:
epublish
Résumé
Respiratory Syncytial Virus (RSV) is a highly prevalent virus that affects the majority of the population. The virus can cause severe disease in vulnerable populations leading to high hospitalization rates from bronchiolitis or secondary bacterial infections leading to pneumonia. Two early and non-structural proteins (Ns1 and Ns2), strongly over-ride the antiviral innate system but also diminish the adaptive response as well. This review will cover interactions of Ns1 and Ns2 with the host antiviral response with a focus on alterations to signaling pathways, cytokine gene expression, and effects of the Ns proteins on mitochondria.
Identifiants
pubmed: 32509597
doi: 10.3389/fcimb.2020.00225
pmc: PMC7248305
doi:
Substances chimiques
Cytokines
0
Viral Nonstructural Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
225Informations de copyright
Copyright © 2020 Thornhill and Verhoeven.
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