Investigating the etiologic agents of aseptic meningitis outbreak in Iranian children.
Aseptic meningitis
Iran
outbreak
quantitative PCR
Journal
Journal of family medicine and primary care
ISSN: 2249-4863
Titre abrégé: J Family Med Prim Care
Pays: India
ID NLM: 101610082
Informations de publication
Date de publication:
Mar 2020
Mar 2020
Historique:
received:
12
11
2019
revised:
25
01
2020
accepted:
07
02
2020
entrez:
9
6
2020
pubmed:
9
6
2020
medline:
9
6
2020
Statut:
epublish
Résumé
This study aimed to determine the viral agent (s) and their genome burden associated with an aseptic meningitis outbreak that occurred in Yasuj, Iran. During April to August 2015, 104 CSF samples from 104 patients under 14 years old admitted to the hospital of Yasuj, Iran, with aseptic meningitis associated clinical signs were collected. 200 μl CSF specimens was prepared for DNA and RNA viral genome extraction each and then subjected to diagnostic Taq-man real time PCR assays for the present of Enteroviruses, HSV, VZV, mumps, measles and rubella in the samples. The majority of them had experienced clinical meningitis sign. Primary laboratory differentiated tests were in favor of viral meningitis. Among a total of 104 patients diagnosed with clinically aseptic meningitis, enterovirus as the most significant viral agent was detected in 53 subjects. However, mumps, HSV and VZV, as the endemic causes of viral meningitis, were detected in 6, 6 and 2 of the affected patients. It was revealed that two HSV and one VZV affected patients were co-infected with enteroviruses. All affected children with relatively variable viral load recovered without any sequels. The present study revealed enterovirus as the main predominant cause of pediatric aseptic meningitis that broke out in Yasuj-Iran. Also, the co-circulation of mumps, HSV and VZV, as the endemic cause during the same aseptic meningitis outbreak, was demonstrated in some cases.
Identifiants
pubmed: 32509652
doi: 10.4103/jfmpc.jfmpc_1003_19
pii: JFMPC-9-1573
pmc: PMC7266184
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1573-1577Informations de copyright
Copyright: © 2020 Journal of Family Medicine and Primary Care.
Déclaration de conflit d'intérêts
There are no conflicts of interest.
Références
Pediatr Infect Dis J. 2016 May;35(5):567-9
pubmed: 26862675
Virol J. 2012 Feb 15;9:38
pubmed: 22336050
J Clin Microbiol. 2002 Dec;40(12):4439-44
pubmed: 12454133
J Clin Virol. 2017 Sep;94:110-114
pubmed: 28806629
Rev Med Virol. 2020 Jan;30(1):e2082
pubmed: 31588651
Hosp Pediatr. 2017 Feb;7(2):96-102
pubmed: 28082417
Medicine (Baltimore). 2019 Apr;98(14):e15077
pubmed: 30946358
BMC Infect Dis. 2018 Dec 29;18(1):709
pubmed: 30594238
J Med Virol. 2011 May;83(5):884-8
pubmed: 21412795
Einstein (Sao Paulo). 2017 Apr-Jun;15(2):167-172
pubmed: 28767914
BMJ Open Ophthalmol. 2019 Apr 9;4(1):e000247
pubmed: 31179395
Arch Virol. 2007;152(10):1807-17
pubmed: 17610124
BMC Infect Dis. 2019 May 2;19(1):370
pubmed: 31046684
Virus Genes. 2015 Apr;50(2):177-88
pubmed: 25537948
MMWR Morb Mortal Wkly Rep. 2015 Jan 2;63(51):1228
pubmed: 25551596
Lancet Infect Dis. 2018 Dec;18(12):1385-1396
pubmed: 30389482
Pol J Microbiol. ;65(2):231-5
pubmed: 28520332
Virol J. 2013 Aug 23;10:263
pubmed: 23968330
J Clin Virol. 2008 Jun;42(2):225-8
pubmed: 18358773
Virology. 2018 Mar;516:196-201
pubmed: 29407377
Curr Opin Infect Dis. 2007 Jun;20(3):272-7
pubmed: 17471037
Braz J Infect Dis. 2009 Oct;13(5):367-70
pubmed: 20428638
J Med Virol. 2002 Feb;66(2):224-8
pubmed: 11782931
JAMA Pediatr. 2017 Oct 1;171(10):992-998
pubmed: 28806450
Jundishapur J Microbiol. 2016 Mar 07;9(5):e19955
pubmed: 27478556
Infect Genet Evol. 2019 Nov;75:103965
pubmed: 31319177
Curr Opin Infect Dis. 2017 Apr;30(2):248-256
pubmed: 28118219
Vaccine. 2007 Aug 1;25(31):5793-802
pubmed: 17574313
Viruses. 2016 Jan 06;8(1):
pubmed: 26751470
J Clin Microbiol. 2006 Nov;44(11):4142-8
pubmed: 16957029