Small Molecule Chaperones for the Treatment of Gaucher Disease and

GBA1 Parkinson disease gaucher disease glucocerebrosidase lysosome small molecule chaperones

Journal

Frontiers in cell and developmental biology
ISSN: 2296-634X
Titre abrégé: Front Cell Dev Biol
Pays: Switzerland
ID NLM: 101630250

Informations de publication

Date de publication:
2020
Historique:
received: 25 01 2020
accepted: 30 03 2020
entrez: 9 6 2020
pubmed: 9 6 2020
medline: 9 6 2020
Statut: epublish

Résumé

Parkinson disease, the second most common movement disorder, is a complex neurodegenerative disorder hallmarked by the accumulation of alpha-synuclein, a neural-specific small protein associated with neuronal synapses. Mutations in the glucocerebrosidase gene (

Identifiants

pubmed: 32509770
doi: 10.3389/fcell.2020.00271
pmc: PMC7248408
doi:

Types de publication

Journal Article Review

Langues

eng

Pagination

271

Informations de copyright

Copyright © 2020 Han, Sam and Sidransky.

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Auteurs

Tae-Un Han (TU)

Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, United States.

Richard Sam (R)

Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, United States.

Ellen Sidransky (E)

Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, United States.

Classifications MeSH