Near-atomic structures of the BBSome reveal the basis for BBSome activation and binding to GPCR cargoes.
BBSome
Bardet-Biedl Syndrome
Cilia
GPCR
cell biology
hedgehog signaling
molecular biophysics
mouse
smoothened
structural biology
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
08 06 2020
08 06 2020
Historique:
received:
12
02
2020
accepted:
08
06
2020
pubmed:
9
6
2020
medline:
13
3
2021
entrez:
9
6
2020
Statut:
epublish
Résumé
Dynamic trafficking of G protein-coupled receptors (GPCRs) out of cilia is mediated by the BBSome. In concert with its membrane recruitment factor, the small GTPase ARL6/BBS3, the BBSome ferries GPCRs across the transition zone, a diffusion barrier at the base of cilia. Here, we present the near-atomic structures of the BBSome by itself and in complex with ARL6
Identifiants
pubmed: 32510327
doi: 10.7554/eLife.55954
pii: 55954
pmc: PMC7311171
doi:
pii:
Substances chimiques
Carrier Proteins
0
Receptors, G-Protein-Coupled
0
Recombinant Proteins
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIGMS NIH HHS
ID : P41 GM103311
Pays : United States
Organisme : Research to Prevent Blindness
ID : A131667
Pays : International
Organisme : NCRR NIH HHS
ID : M01 RR001271
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK098722
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY031462
Pays : United States
Organisme : Austrian Science Fund FWF
ID : P 30162
Pays : Austria
Organisme : NIGMS NIH HHS
ID : R01 GM089933
Pays : United States
Organisme : NEI NIH HHS
ID : P30 EY002162
Pays : United States
Informations de copyright
© 2020, Yang et al.
Déclaration de conflit d'intérêts
SY, KB, HC, JW, US, TW, MN No competing interests declared
Références
Nature. 2013 May 16;497(7449):338-43
pubmed: 23636324
Cell. 2010 Jun 25;141(7):1208-19
pubmed: 20603001
Mol Cell. 2004 Mar 12;13(5):677-88
pubmed: 15023338
Cell. 2013 Feb 14;152(4):755-67
pubmed: 23415225
Biochemistry. 2002 Jul 2;41(26):8298-309
pubmed: 12081478
Proc Natl Acad Sci U S A. 2011 Dec 20;108(51):20678-83
pubmed: 22139371
Proc Natl Acad Sci U S A. 2020 Feb 4;117(5):2496-2505
pubmed: 31953262
Nat Methods. 2017 Apr;14(4):331-332
pubmed: 28250466
Int J Mol Sci. 2016 Nov 18;17(11):
pubmed: 27869740
J Cell Biol. 2018 May 7;217(5):1847-1868
pubmed: 29483145
EMBO J. 1998 Sep 15;17(18):5374-87
pubmed: 9736615
Mol Biol Cell. 2008 Apr;19(4):1540-7
pubmed: 18256283
Elife. 2017 Jun 16;6:
pubmed: 28621666
FEBS Lett. 2010 May 3;584(9):1840-7
pubmed: 19837069
Nat Genet. 2011 Jun;43(6):547-53
pubmed: 21552265
Essays Biochem. 2018 Dec 7;62(6):753-763
pubmed: 30287585
Cell Rep. 2015 Sep 1;12(9):1519-30
pubmed: 26299969
Nat Commun. 2014 Jul 10;5:4355
pubmed: 25008467
J Cell Biol. 2017 Mar 6;216(3):743-760
pubmed: 28154160
Cell. 2013 Jan 17;152(1-2):210-23
pubmed: 23332756
PLoS One. 2013 Aug 02;8(8):e70857
pubmed: 23936473
J Comput Chem. 2004 Oct;25(13):1605-12
pubmed: 15264254
Nat Commun. 2014;5:3309
pubmed: 24525480
Cell. 2019 Nov 27;179(6):1289-1305.e21
pubmed: 31761534
Nature. 2016 Jul 28;535(7613):517-522
pubmed: 27437577
J Struct Biol. 2015 Nov;192(2):216-21
pubmed: 26278980
Nat Methods. 2017 Mar;14(3):290-296
pubmed: 28165473
Cell. 2007 Jun 15;129(6):1201-13
pubmed: 17574030
Elife. 2020 Jan 15;9:
pubmed: 31939736
J Cell Sci. 2019 May 15;132(10):
pubmed: 30975916
Nat Commun. 2016 May 13;7:11491
pubmed: 27173435
Dev Cell. 2014 Nov 10;31(3):279-290
pubmed: 25446516
Proc Natl Acad Sci U S A. 2014 Jul 15;111(28):10335-40
pubmed: 24982149
Cell. 2018 Jul 12;174(2):312-324.e16
pubmed: 29804838
PLoS One. 2015 Jun 08;10(6):e0128422
pubmed: 26053317
J Mol Biol. 2003 Oct 31;333(4):721-45
pubmed: 14568533
Nat Rev Mol Cell Biol. 2019 Jul;20(7):389-405
pubmed: 30948801
EMBO J. 2012 May 30;31(11):2590-603
pubmed: 22522702
PLoS Genet. 2011 Nov;7(11):e1002358
pubmed: 22072986
Mol Biol Cell. 2019 May 15;30(11):1249-1271
pubmed: 31084567
Biochim Biophys Acta. 2004 Nov 3;1666(1-2):40-50
pubmed: 15519307
J Cell Biol. 2013 Oct 14;203(1):129-47
pubmed: 24100294
Nucleic Acids Res. 2018 Jan 4;46(D1):D440-D446
pubmed: 29155946
Nat Commun. 2017 May 17;8:15383
pubmed: 28513578
Proc Natl Acad Sci U S A. 2015 Jul 7;112(27):8320-5
pubmed: 26100903
Nat Struct Mol Biol. 2014 Dec;21(12):1035-41
pubmed: 25402481
Biol Open. 2019 Sep 17;8(9):
pubmed: 31471295
Nature. 2019 Jul;571(7764):279-283
pubmed: 31168089
Mol Pharmacol. 2015 Sep;88(3):536-51
pubmed: 26152196
J Struct Biol. 2005 Oct;152(1):36-51
pubmed: 16182563
Acta Crystallogr D Biol Crystallogr. 2004 Dec;60(Pt 12 Pt 1):2126-32
pubmed: 15572765
PLoS One. 2017 Mar 14;12(3):e0173399
pubmed: 28291807
Curr Opin Cell Biol. 2018 Apr;51:124-131
pubmed: 29579578
Acta Crystallogr D Biol Crystallogr. 2010 Feb;66(Pt 2):213-21
pubmed: 20124702
Nat Genet. 2018 Feb;50(2):180-185
pubmed: 29311635
Elife. 2018 Nov 09;7:
pubmed: 30412051
Curr Opin Struct Biol. 2014 Dec;29:67-76
pubmed: 25460270
Nucleic Acids Res. 2018 Jul 2;46(W1):W296-W303
pubmed: 29788355
Nat Rev Nephrol. 2019 Apr;15(4):199-219
pubmed: 30733609
J Cell Biol. 2009 Nov 2;187(3):365-74
pubmed: 19948480
Cold Spring Harb Perspect Biol. 2017 Feb 1;9(2):
pubmed: 27770015
PLoS One. 2010 May 28;5(5):e10902
pubmed: 20531939
Cell Rep. 2013 Dec 12;5(5):1316-29
pubmed: 24316073
Nature. 2019 Jul;571(7764):284-288
pubmed: 31263273
Elife. 2017 Nov 15;6:
pubmed: 29168691
Dev Cell. 2007 Nov;13(5):635-45
pubmed: 17981133
Trends Cell Biol. 2013 Jun;23(6):279-88
pubmed: 23414967
Structure. 2015 Nov 3;23(11):1977-88
pubmed: 26365802
Dev Cell. 2014 Sep 8;30(5):610-24
pubmed: 25203211
Structure. 2019 Sep 3;27(9):1384-1394.e4
pubmed: 31303482
Elife. 2020 Jan 17;9:
pubmed: 31951201
Cell. 2010 Jun 25;141(7):1220-9
pubmed: 20603002
Nat Methods. 2017 Dec;14(12):1213-1221
pubmed: 29039417
Proc Natl Acad Sci U S A. 2018 Jan 30;115(5):E934-E943
pubmed: 29339469
Cold Spring Harb Perspect Biol. 2017 May 1;9(5):
pubmed: 27881449
Mol Cell. 2003 Oct;12(4):863-74
pubmed: 14580338
Cell. 2012 Feb 3;148(3):530-42
pubmed: 22304919