Effect of Nigella sativa oil supplement on risk factors for cardiovascular diseases in patients with type 2 diabetes mellitus.
Nigella sativa
diabetes
hs-CRP
oxidative stress
serum lipids
Journal
Phytotherapy research : PTR
ISSN: 1099-1573
Titre abrégé: Phytother Res
Pays: England
ID NLM: 8904486
Informations de publication
Date de publication:
Oct 2020
Oct 2020
Historique:
received:
24
11
2019
revised:
23
03
2020
accepted:
07
04
2020
pubmed:
9
6
2020
medline:
1
12
2020
entrez:
9
6
2020
Statut:
ppublish
Résumé
This study aimed to evaluate the effects of Nigella sativa oil on serum level of systemic inflammation, oxidative stress, fasting blood glucose (FBG), and lipid profile in patients with type 2 diabetes mellitus (T2DM). This double-blind randomized clinical trial study was based on 50 patients with T2DM. Patients were allocated randomly to either N. sativa oil or placebo groups. The intervention group received 1,000 mg N. sativa oil as two capsules, daily for 8 weeks, whereas the placebo group received a corresponding placebo. At baseline and the end of the study, 5 ml blood was collected from each patient after 14-hour fasting for measuring serum C-reactive protein (hs-CRP), malondialdehyde (MDA), FBS, and lipid profile. Analyses covariance was performed to compare investigated parameters between two groups, controlled for relevant covariates. Using N. sativa supplement was significantly associated with decrease in FBS (p < .001), triglyceride (p < .001), total cholesterol (p < .001), low-density lipoprotein cholesterol (p < .001), serum hs-CRP, MDA (p < .001) and increase in serum level of high-density lipoprotein cholesterol (p < .001) in intervention group compared with placebo group. Nigella sativa oil supplement has cardiovascular protective effects in patients with T2DM, by improving the lipid profile and glycemia, by reducing the C-reactive protein level and the lipid peroxidation.
Substances chimiques
Plant Oils
0
caraway oil
C2J9B08Q3I
Types de publication
Journal Article
Randomized Controlled Trial
Langues
eng
Sous-ensembles de citation
IM
Pagination
2706-2711Informations de copyright
© 2020 John Wiley & Sons, Ltd.
Références
Al Wafai, R. J. (2013). Nigella sativa and thymoquinone suppress cyclooxygenase-2 and oxidative stress in pancreatic tissue of streptozotocin-induced diabetic rats. Pancreas, 42(5), 841-849.
Asgary, S., Sahebkar, A., & Goli-Malekabadi, N. (2015). Ameliorative effects of Nigella sativa on dyslipidemia. Journal of Endocrinological Investigation, 38(10), 1039-1046.
Badar, A., Kaatabi, H., Bamosa, A., Al-Elq, A., Abou-Hozaifa, B., Lebda, F., … Al-Almaie, S. (2017). Effect of Nigella sativa supplementation over a one-year period on lipid levels, blood pressure and heart rate in type-2 diabetic patients receiving oral hypoglycemic agents: Nonrandomized clinical trial. Annals of Saudi Medicine, 37(1), 56-63.
Balbaa, M., El-Zeftawy, M., Ghareeb, D., Taha, N., & Mandour, A. W. (2016). Nigella sativa relieves the altered insulin receptor signaling in streptozotocin-induced diabetic rats fed with a high-fat diet. Oxidative Medicine and Cellular Longevity, 2016, 1.
Bensiameur-Touati, K., Kacimi, G., Haffaf, E.-M., Berdja, S., & Aouichat-Bouguerra, S. (2017). In vivo subacute toxicity and antidiabetic effect of aqueous extract of Nigella sativa. Evidence-based Complementary and Alternative Medicine, 2017, 1.
Borm, G. F., Fransen, J., & Lemmens, W. A. J. G. (2007). A simple sample size formula for analysis of covariance in randomized clinical trials. Journal of Clinical Epidemiology, 60(12), 1234-1238. https://doi.org/10.1016/j.jclinepi.2007.02.006
Caskurlu, T., Kanter, M., Erboga, M., Erboga, Z. F., Ozgul, M., & Atis, G. (2016). Protective effect of Nigella sativa on renal reperfusion injury in rat. Iranian Journal of Kidney Diseases, 10(3), 135-143.
Daryabeygi-Khotbehsara, R., Golzarand, M., Ghaffari, M. P., & Djafarian, K. (2017). Nigella sativa improves glucose homeostasis and serum lipids in type 2 diabetes: A systematic review and meta-analysis. Complementary Therapies in Medicine, 35, 6-13.
Datau, E., Surachmanto, E., Pandelaki, K., & Langi, J. (2010). Efficacy of Nigella sativa on serum free testosterone and metabolic disturbances in central obese male. Acta Medica Indonesiana, 42(3), 130-134.
El-Deeb, H., Elrehany, M., Elbawb Elsaid, M., & Younis, H. (2010). Biochemical effect of Nigella sativa on patients with coronary artery disease. El-Minia Medical Bulletin, 21, 25-36.
Elsherbiny, N. M., Maysarah, N. M., El-Sherbiny, M., & Al-Gayyar, M. M. (2017). Renal protective effects of thymoquinone against sodium nitrite-induced chronic toxicity in rats: Impact on inflammation and apoptosis. Life Sciences, 180, 1-8.
Franz, M. J., Bantle, J. P., Beebe, C. A., Brunzell, J. D., Chiasson, J. L., Garg, A., … Mooradian, A. D. (2003). Evidence-based nutrition principles and recommendations for the treatment and prevention of diabetes and related complications. Diabetes Care, 26, S51.
Greenland, P., Knoll, M. D., Stamler, J., Neaton, J. D., Dyer, A. R., Garside, D. B., & Wilson, P. W. (2003). Major risk factors as antecedents of fatal and nonfatal coronary heart disease events. JAMA, 290(7), 891-897.
Heshmati, J., Farsi, F., Shokri, F., Rezaeinejad, M., Almasi-Hashiani, A., Vesali, S., & Sepidarkish, M. (2018). A systematic review and meta-analysis of the probiotics and synbiotics effects on oxidative stress. Journal of Functional Foods, 46, 66-84. https://doi.org/10.1016/j.jff.2018.04.049
Heshmati, J., Morvaridzadeh, M., Maroufizadeh, S., Akbari, A., Yavari, M., Amirinejad, A., … Sepidarkish, M. (2019). Omega-3 fatty acids supplementation and oxidative stress parameters: A systematic review and meta-analysis of clinical trials. Pharmacological Research, 149, 104462. https://doi.org/10.1016/j.phrs.2019.104462
Heshmati, J., Namazi, N., Memarzadeh, M.-R., Taghizadeh, M., & Kolahdooz, F. (2015). Nigella sativa oil affects glucose metabolism and lipid concentrations in patients with type 2 diabetes: A randomized, double-blind, placebo-controlled trial. Food Research International, 70, 87-93. https://doi.org/10.1016/j.foodres.2015.01.030
Jager, A., van Hinsbergh, V. W., Kostense, P. J., Emeis, J. J., Yudkin, J. S., Nijpels, G., … Stehouwer, C. D. (1999). von Willebrand factor, C-reactive protein, and 5-year mortality in diabetic and nondiabetic subjects: The Hoorn study. Arteriosclerosis, Thrombosis, and Vascular Biology, 19(12), 3071-3078.
Kaatabi, H., Bamosa, A. O., Lebda, F. M., Al Elq, A. H., & Al-Sultan, A. I. (2012). Favorable impact of Nigella sativa seeds on lipid profile in type 2 diabetic patients. Journal of Family & Community Medicine, 19(3), 155-161.
Kheirouri, S., Hadi, V., & Alizadeh, M. (2016). Immunomodulatory effect of Nigella sativa oil on T lymphocytes in patients with rheumatoid arthritis. Immunological Investigations, 45(4), 271-283.
Kooshki, A., & Golafrooz, M. (2009). Nutrient intakes affecting bone formation compared with dietary reference intake (DRI) in Sabzevar elderly subjects. Pakistan Journal of Nutrition, 8(3), 218-221. https://doi.org/10.3923/pjn.2009.218.221
Mahdavi, R., Namazi, N., Alizadeh, M., & Farajnia, S. (2016). Nigella sativa oil with a calorie-restricted diet can improve biomarkers of systemic inflammation in obese women: A randomized double-blind, placebo-controlled clinical trial. Journal of Clinical Lipidology, 10(5), 1203-1211. https://doi.org/10.1016/j.jacl.2015.11.019
Mendes-Braz, M., & Martins, J. O. (2018). Diabetes mellitus and liver surgery: The effect of diabetes on oxidative stress and inflammation. Mediators of Inflammation, 2018, 1.
Mohebbati, R., Shafei, M. N., Soukhtanloo, M., Roshan, N. M., Rad, A. K., Anaeigoudari, A., … Beheshti, F. (2016). Adriamycin-induced oxidative stress is prevented by mixed hydro-alcoholic extract of Nigella sativa and Curcuma longa in rat kidney. Avicenna Journal of Phytomedicine, 6(1), 86-94.
Mohtashami, A., & Entezari, M. H. (2016). Effects of Nigella sativa supplementation on blood parameters and anthropometric indices in adults: A systematic review on clinical trials. Journal of Research in Medical Sciences, 21, 3.
Nagi, M. N., & Mansour, M. A. (2000). Protective effect of thymoquinone against doxorubicin-induced cardiotoxicity in rats: A possible mechanism of protection. Pharmacological Research, 41(3), 283-289.
Namazi, N., Mahdavi, R., Alizadeh, M., & Farajnia, S. (2015). Oxidative stress responses to Nigella sativa oil concurrent with a low-calorie diet in obese women: A randomized, double-blind controlled clinical trial. Phytotherapy Research, 29(11), 1722-1728.
Nasir, A., Siddiqui, M. Y., & Mohsin, M. (2017). Therapeutic uses of Shoneez (Nigella sativa Linn.) mentioned in Unani system of medicine-a review. International Journal of Pharmaceutical and Phytopharmacological Research, 4(1), 47-49.
Pickup, J., Mattock, M., Chusney, G., & Burt, D. (1997). NIDDM as a disease of the innate immune system: Association of acute-phase reactants and interleukin-6 with metabolic syndrome X. Diabetologia, 40(11), 1286-1292.
Ragheb, A., Attia, A., Eldin, W. S., Elbarbry, F., Gazarin, S., & Shoker, A. (2009). The protective effect of thymoquinone, an anti-oxidant and anti-inflammatory agent, against renal injury: A review. Saudi Journal of Kidney Diseases and Transplantation, 20(5), 741-752.
Randhawa, M. A., & Alghamdi, M. S. (2011). Anticancer activity of Nigella sativa (black seed)-A review. The American Journal of Chinese Medicine, 39(06), 1075-1091.
Sahebkar, A., Beccuti, G., Simental-Mendía, L. E., Nobili, V., & Bo, S. (2016). Nigella sativa (black seed) effects on plasma lipid concentrations in humans: A systematic review and meta-analysis of randomized placebo-controlled trials. Pharmacological Research, 106, 37-50.
Sepidarkish, M., Farsi, F., Akbari-Fakhrabadi, M., Namazi, N., Almasi-Hashiani, A., Maleki Hagiagha, A., & Heshmati, J. (2019). The effect of vitamin D supplementation on oxidative stress parameters: A systematic review and meta-analysis of clinical trials. Pharmacological Research, 139, 141-152. https://doi.org/10.1016/j.phrs.2018.11.011
Shirzadeh, E., Kooshki, A., & Mohammadi, M. (2016). The relationship between breastfeeding and measurements of refraction and visual acuity in primary school children. Breastfeeding Medicine, 11(5), 235-238. https://doi.org/10.1089/bfm.2016.0010
Stehouwer, C. D., Gall, M.-A., Twisk, J. W., Knudsen, E., Emeis, J. J., & Parving, H.-H. (2002). Increased urinary albumin excretion, endothelial dysfunction, and chronic low-grade inflammation in type 2 diabetes: Progressive, interrelated, and independently associated with risk of death. Diabetes, 51(4), 1157-1165.
Sultan, M. T., Butt, M. S., Karim, R., Zia-Ul-Haq, M., Batool, R., Ahmad, S., … De Feo, V. (2014). Nigella sativa fixed and essential oil supplementation modulates hyperglycemia and allied complications in streptozotocin-induced diabetes mellitus. Evidence-based Complementary and Alternative Medicine, 2014, 1.
Who & Organization (2003). Diet, nutrition and the prevention of chronic diseases: report of a joint WH.
Wild, S., Roglic, G., Green, A., Sicree, R., & King, H. (2004). Global prevalence of diabetes: Estimates for the year 2000 and projections for 2030. Diabetes Care, 27(5), 1047-1053.