SARS-CoV-2 seroprevalence and neutralizing activity in donor and patient blood from the San Francisco Bay Area.

Journal

medRxiv : the preprint server for health sciences

Titre abrégé: medRxiv

Pays: United States

ID NLM: 101767986

Informations de publication

Date de publication:
25 May 2020

Historique:

entrez: 9 6 2020

pubmed: 9 6 2020

medline: 9 6 2020

Statut: epublish

Résumé

We report very low SARS-CoV-2 seroprevalence in two San Francisco Bay Area populations. Seropositivity was 0.26% in 387 hospitalized patients admitted for non-respiratory indications and 0.1% in 1,000 blood donors. We additionally describe the longitudinal dynamics of immunoglobulin-G, immunoglobulin-M, and in vitro neutralizing antibody titers in COVID-19 patients. Neutralizing antibodies rise in tandem with immunoglobulin levels following symptom onset, exhibiting median time to seroconversion within one day of each other, and there is >93% positive percent agreement between detection of immunoglobulin-G and neutralizing titers.

Identifiants

DOI: 10.1101/2020.05.19.20107482 PMID: 32511477 PMC: PMC7273245

pubmed: 32511477

doi: 10.1101/2020.05.19.20107482

pmc: PMC7273245

pii:

doi:

Types de publication

Preprint

Langues

eng

Subventions

Organisme : NIAID NIH HHS

ID : L40 AI140341

Pays : United States

Organisme : NHLBI NIH HHS

ID : R01 HL105704

Pays : United States

Organisme : NHLBI NIH HHS

ID : R38 HL143581

Pays : United States

Commentaires et corrections

Type : UpdateIn

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Auteurs

Dianna L Ng (DL)

Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA, USA.

Department of Pathology, University of California, San Francisco, San Francisco, CA, USA.

Gregory M Goldgof (GM)

Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA, USA.

Brian R Shy (BR)

Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA, USA.

Andrew G Levine (AG)

Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA, USA.

Joanna Balcerek (J)

Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA, USA.

Sagar P Bapat (SP)

Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA, USA.

John Prostko (J)

Applied Research and Technology, Abbott Diagnostics, Abbott Park, IL, USA.

Mary Rodgers (M)

Applied Research and Technology, Abbott Diagnostics, Abbott Park, IL, USA.

Kelly Coller (K)

Applied Research and Technology, Abbott Diagnostics, Abbott Park, IL, USA.

Sandy Pearce (S)

Applied Research and Technology, Abbott Diagnostics, Abbott Park, IL, USA.

Sergej Franz (S)

Vitalant Research Institute, San Francisco, CA, USA.

Li Du (L)

Vitalant Research Institute, San Francisco, CA, USA.

Mars Stone (M)

Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA, USA.

Vitalant Research Institute, San Francisco, CA, USA.

Satish K Pillai (SK)

Vitalant Research Institute, San Francisco, CA, USA.

Alicia Sotomayor-Gonzalez (A)

Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA, USA.

UCSF-Abbott Viral Diagnostics and Discovery Center, San Francisco, CA, USA.

Venice Servellita (V)

Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA, USA.

UCSF-Abbott Viral Diagnostics and Discovery Center, San Francisco, CA, USA.

Claudia Sanchez San Martin (CSS)

Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA, USA.

UCSF-Abbott Viral Diagnostics and Discovery Center, San Francisco, CA, USA.

Andrea Granados (A)

Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA, USA.

UCSF-Abbott Viral Diagnostics and Discovery Center, San Francisco, CA, USA.

Dustin R Glasner (DR)

Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA, USA.

UCSF-Abbott Viral Diagnostics and Discovery Center, San Francisco, CA, USA.

Lucy M Han (LM)

Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA, USA.

Department of Pathology, University of California, San Francisco, San Francisco, CA, USA.

Kent Truong (K)

Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA, USA.

Department of Pathology, University of California, San Francisco, San Francisco, CA, USA.

Naomi Akagi (N)

Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA, USA.

Department of Pathology, University of California, San Francisco, San Francisco, CA, USA.

David N Nguyen (DN)

Department of Medicine, Division of Infectious Diseases, University of California, San Francisco, San Francisco, CA, USA.

Neil M Neumann (NM)

Department of Pathology, University of California, San Francisco, San Francisco, CA, USA.

Daniel Qazi (D)

Department of Pathology, University of California, San Francisco, San Francisco, CA, USA.

Elaine Hsu (E)

Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA, USA.

Wei Gu (W)

Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA, USA.

Yale A Santos (YA)

Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA, USA.

UCSF-Abbott Viral Diagnostics and Discovery Center, San Francisco, CA, USA.

Brian Custer (B)

Vitalant Research Institute, San Francisco, CA, USA.

Valerie Green (V)

Creative Testing Solutions, Tempe, AZ, USA.

Phillip Williamson (P)

Creative Testing Solutions, Tempe, AZ, USA.

Nancy K Hills (NK)

Department of Neurology, University of California, San Francisco, San Francisco, CA, USA.

Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, USA.

Chuanyi M Lu (CM)

Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA, USA.

Lab Medicine Service, San Francisco VA Healthcare System.

Jeffrey D Whitman (JD)

Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA, USA.

Susan Stramer (S)

American Red Cross, Gaithersburg, MD, USA.

Candace Wang (C)

Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA, USA.

UCSF-Abbott Viral Diagnostics and Discovery Center, San Francisco, CA, USA.

Kevin Reyes (K)

Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA, USA.

UCSF-Abbott Viral Diagnostics and Discovery Center, San Francisco, CA, USA.

Jill M C Hakim (JMC)

Department of Medicine at ZSFG, the Division of HIV, ID & Global Medicine.

Kirk Sujishi (K)

Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA, USA.

Fariba Alazzeh (F)

Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA, USA.

Lori Pham (L)

Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA, USA.

Ching-Ying Oon (CY)

Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA, USA.

Steve Miller (S)

Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA, USA.

UCSF-Abbott Viral Diagnostics and Discovery Center, San Francisco, CA, USA.

Theodore Kurtz (T)

Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA, USA.

John Hackett (J)

Applied Research and Technology, Abbott Diagnostics, Abbott Park, IL, USA.

Graham Simmons (G)

Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA, USA.

Vitalant Research Institute, San Francisco, CA, USA.

Michael P Busch (MP)

Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA, USA.

Vitalant Research Institute, San Francisco, CA, USA.

Charles Y Chiu (CY)

Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA, USA.

UCSF-Abbott Viral Diagnostics and Discovery Center, San Francisco, CA, USA.

Department of Medicine, Division of Infectious Diseases, University of California, San Francisco, San Francisco, CA, USA.

Classifications MeSH