The effect of insulin-like growth factor 1 on the recovery of facial nerve function in a guinea pig model of facial palsy.
Electroneurography
Gelatin-based hydrogel
Insulin-like growth factor 1
Peripheral facial nerve palsy
Physiological function
Journal
The journal of physiological sciences : JPS
ISSN: 1880-6562
Titre abrégé: J Physiol Sci
Pays: Japan
ID NLM: 101262417
Informations de publication
Date de publication:
08 Jun 2020
08 Jun 2020
Historique:
received:
09
09
2019
accepted:
21
05
2020
entrez:
10
6
2020
pubmed:
10
6
2020
medline:
19
5
2021
Statut:
epublish
Résumé
The efficacy of insulin-like growth factor 1 (IGF-1) in the treatment of peripheral facial nerve palsy was investigated using an animal model. The facial nerve within the temporal bone was exposed and compressed by clamping. The animals were treated with either IGF-1 or saline which was topically administered by a gelatin-based sustained-release hydrogel via an intratemporal route. The recovery from facial nerve palsy was evaluated at 8 weeks postoperatively based on eyelid closure, complete recovery rate, electroneurography and number of axons found on the facial nerve. IGF-1 treatment resulted in significant improvement in the changes of the degree of eyelid closure over the total time period and complete recovery rate. A separate study showed that IGF-1 receptor mRNA was expressed in facial nerves up to 14 days after the nerve-clamping procedure. IGF-1 was thus found to be effective in the treatment of peripheral facial nerve palsy when topically applied using a sustained-release gelatin-based hydrogel via an intratemporal route.
Identifiants
pubmed: 32513097
doi: 10.1186/s12576-020-00755-0
pii: 10.1186/s12576-020-00755-0
pmc: PMC10717557
doi:
Substances chimiques
Insulin-Like Growth Factor I
67763-96-6
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
28Subventions
Organisme : JSPS Grants-in-Aid For Scientific Research
ID : 18K16873
Organisme : JSPS Grants-in-Aid For Scientific Research
ID : 16H05479
Organisme : JSPS Grants-in-Aid For Scientific Research
ID : 17K16888
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