Drug dosing in the critically ill obese patient-a focus on sedation, analgesia, and delirium.
Analgesia
/ methods
Analgesics, Non-Narcotic
/ administration & dosage
Analgesics, Opioid
/ administration & dosage
Benzodiazepines
/ administration & dosage
Critical Illness
/ therapy
Deep Sedation
/ methods
Delirium
/ etiology
Dexmedetomidine
/ administration & dosage
Dose-Response Relationship, Drug
Etomidate
/ administration & dosage
Haloperidol
/ administration & dosage
Humans
Ketamine
/ administration & dosage
Obesity
/ drug therapy
Pain Management
/ methods
Quetiapine Fumarate
/ administration & dosage
Critical illness
Drug-dosing
Obesity
Pharmacokinetics
Journal
Critical care (London, England)
ISSN: 1466-609X
Titre abrégé: Crit Care
Pays: England
ID NLM: 9801902
Informations de publication
Date de publication:
08 06 2020
08 06 2020
Historique:
received:
10
03
2020
accepted:
27
05
2020
entrez:
10
6
2020
pubmed:
10
6
2020
medline:
2
3
2021
Statut:
epublish
Résumé
Practice guidelines provide clear evidence-based recommendations for the use of drug therapy to manage pain, agitation, and delirium associated with critical illness. Dosing recommendations however are often based on strategies used in patients with normal body habitus. Recommendations specific to critically ill patients with extreme obesity are lacking. Nonetheless, clinicians must craft dosing regimens for this population. This paper is intended to help clinicians design initial dosing regimens for medications commonly used in the management of pain, agitation, and delirium in critically ill patients with extreme obesity. A detailed literature search was conducted with an emphasis on obesity, pharmacokinetics, and dosing. Relevant manuscripts were reviewed and strategies for dosing are provided.
Identifiants
pubmed: 32513237
doi: 10.1186/s13054-020-03040-z
pii: 10.1186/s13054-020-03040-z
pmc: PMC7282067
doi:
Substances chimiques
Analgesics, Non-Narcotic
0
Analgesics, Opioid
0
Benzodiazepines
12794-10-4
Quetiapine Fumarate
2S3PL1B6UJ
Dexmedetomidine
67VB76HONO
Ketamine
690G0D6V8H
Haloperidol
J6292F8L3D
Etomidate
Z22628B598
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
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