Assessment of insulin resistance in the skeletal muscle of mice using positron emission tomography/computed tomography imaging.
Animals
Diabetes Mellitus, Experimental
/ diagnostic imaging
Diet, High-Fat
/ adverse effects
Fluorodeoxyglucose F18
Glucose
/ metabolism
Insulin Resistance
/ physiology
Male
Mice
Mice, Inbred C57BL
Mice, Mutant Strains
Muscle, Skeletal
/ diagnostic imaging
Obesity
/ diagnostic imaging
Physical Exertion
/ physiology
Positron Emission Tomography Computed Tomography
Radiopharmaceuticals
FDG
Insulin resistance
PET/CT
Skeletal muscle
Journal
Biochemical and biophysical research communications
ISSN: 1090-2104
Titre abrégé: Biochem Biophys Res Commun
Pays: United States
ID NLM: 0372516
Informations de publication
Date de publication:
30 07 2020
30 07 2020
Historique:
received:
14
05
2020
accepted:
22
05
2020
pubmed:
10
6
2020
medline:
9
2
2021
entrez:
10
6
2020
Statut:
ppublish
Résumé
Measuring glucose uptake in the skeletal muscle in vivo is an effective method to determine glucose metabolism abnormalities as the skeletal muscle is the principal tissue responsible for glucose disposal and is a major site of peripheral insulin resistance. In this study, we investigated the pathological glucose metabolism dynamics of the skeletal muscle of C57BL/6J mice in a noninvasive and time-sequential manner using positron emission tomography/computed tomography (PET/CT), an imaging technique that uses radioactive substances to visualize and measure metabolic processes in the body, with [
Identifiants
pubmed: 32513534
pii: S0006-291X(20)31101-3
doi: 10.1016/j.bbrc.2020.05.165
pii:
doi:
Substances chimiques
Radiopharmaceuticals
0
Fluorodeoxyglucose F18
0Z5B2CJX4D
Glucose
IY9XDZ35W2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
499-505Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.