Nectin-2 Expression on Malignant Plasma Cells Is Associated with Better Response to TIGIT Blockade in Multiple Myeloma.
Adult
Aged
Aged, 80 and over
Biomarkers, Tumor
/ analysis
Bone Marrow
/ pathology
Clinical Decision-Making
Female
Humans
Male
Middle Aged
Multiple Myeloma
/ drug therapy
Nectins
/ analysis
Patient Selection
Plasma Cells
/ metabolism
Receptors, Immunologic
/ antagonists & inhibitors
Receptors, Virus
/ analysis
Treatment Outcome
Journal
Clinical cancer research : an official journal of the American Association for Cancer Research
ISSN: 1557-3265
Titre abrégé: Clin Cancer Res
Pays: United States
ID NLM: 9502500
Informations de publication
Date de publication:
01 09 2020
01 09 2020
Historique:
received:
13
11
2019
revised:
08
04
2020
accepted:
03
06
2020
pubmed:
10
6
2020
medline:
26
11
2021
entrez:
10
6
2020
Statut:
ppublish
Résumé
T-cell immunoreceptor with Ig and ITIM domain (TIGIT) blockade could represent an alternative therapeutic option to release the immune response in patients with multiple myeloma. Here we analyzed the expression of TIGIT and its ligands poliovirus receptor (PVR) and nectin-2 in the bone marrow (BM) of patients with monoclonal gammopathies and the efficacy of TIGIT blockade activating antimyeloma immunity. Expression levels of TIGIT and its ligands were characterized by flow cytometry and ELISA. TIGIT blockade was analyzed in TIGIT and its ligands are highly expressed in the BM of patients with multiple myeloma, suggesting that may play a role in restraining immune activation. TIGIT blockade depleted FoxP3 TIGIT blockade efficiently reinvigorated peripheral T cells from patients with multiple myeloma. However, in the BM, the efficacy of blocking anti-TIGIT mAb to achieve tumor cell death may depend on the expression of TIGIT and nectin-2, becoming potential predictive biomarkers for identifying patients who may benefit from TIGIT blockade.
Identifiants
pubmed: 32513837
pii: 1078-0432.CCR-19-3673
doi: 10.1158/1078-0432.CCR-19-3673
doi:
Substances chimiques
Biomarkers, Tumor
0
NECTIN2 protein, human
0
Nectins
0
Receptors, Immunologic
0
Receptors, Virus
0
TIGIT protein, human
0
poliovirus receptor
0
Types de publication
Journal Article
Observational Study
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
4688-4698Informations de copyright
©2020 American Association for Cancer Research.