Combined alcoholic and non-alcoholic steatohepatitis.
ACC, acetyl-CoA carboxylase
ALD
ALD, alcohol-related liver disease
ASH
ASH, alcohol-related steatohepatitis
ASK-1, apoptosis signal-regulating kinase 1
Alcohol
BMI, body mass index
CLD, chronic liver disease
CPT, carnitine palmitoyltransferase
DNL, de novo lipogenesis
EASL, European Association for the Study of the Liver
ER, endoplasmic reticulum
FXR, farnesoid X receptor
HCC, hepatocellular carcinoma
HSD17B13, hydroxysteroid 17-beta dehydrogenase 13
IL, interleukin
LPS, lipopolysaccharide
MBOAT7, membrane bound O-acyl transferase 7
MELD, model for end-stage liver disease
NAFLD
NAFLD, non-alcoholic fatty liver disease
NASH
NASH, non-alcoholic steatohepatitis
OR, odds ratio
PAMP, pathogen-associated molecular pattern
PI3K, phosphatidylinositol-3-kinase
PIP3, phosphatidylinositol 3,4,5-triphosphate
PNPLA3, palatin-like phospholipase domain-containing 3
PRKCE, protein kinase C Epsilon
ROS, reactive oxygen species
SREBP-1c, sterol regulatory element binding protein-1c
TLR, Toll-like receptor
TM6SF2, transmembrane 6 superfamily member 2
TNF-α, tumour necrosis factor-α
WHO, World Health Organization
diabetes
metabolic syndrome
obesity
Journal
JHEP reports : innovation in hepatology
ISSN: 2589-5559
Titre abrégé: JHEP Rep
Pays: Netherlands
ID NLM: 101761237
Informations de publication
Date de publication:
Jun 2020
Jun 2020
Historique:
received:
04
12
2019
revised:
18
02
2020
accepted:
10
03
2020
entrez:
10
6
2020
pubmed:
10
6
2020
medline:
10
6
2020
Statut:
epublish
Résumé
While metabolic syndrome and alcohol consumption are the two main causes of chronic liver disease, one of the two conditions is often predominant, with the other acting as a cofactor of morbimortality. It has been shown that obesity and alcohol act synergistically to increase the risk of fibrosis progression, hepatic carcinogenesis and mortality, while genetic polymorphisms can strongly influence disease progression. Based on common pathogenic pathways, there are several potential targets that could be used to treat both diseases; based on the prevalence and incidence of these diseases, new therapies and clinical trials are needed urgently.
Identifiants
pubmed: 32514497
doi: 10.1016/j.jhepr.2020.100101
pii: S2589-5559(20)30035-5
pii: 100101
pmc: PMC7267467
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
100101Informations de copyright
© 2020 The Authors.
Déclaration de conflit d'intérêts
The authors declare no conflicts of interest that pertain to this work. Please refer to the accompanying ICMJE disclosure forms for further details.
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