Amikacin pharmacokinetic/pharmacodynamic in intensive care unit: a prospective database.
Amikacin
Intensive care unit
Pharmacodynamic
Pharmacokinetic
Journal
Annals of intensive care
ISSN: 2110-5820
Titre abrégé: Ann Intensive Care
Pays: Germany
ID NLM: 101562873
Informations de publication
Date de publication:
08 Jun 2020
08 Jun 2020
Historique:
received:
10
03
2020
accepted:
20
05
2020
entrez:
10
6
2020
pubmed:
10
6
2020
medline:
10
6
2020
Statut:
epublish
Résumé
Aminoglycosides have a concentration-dependent therapeutic effect when peak serum concentration (C Retrospective analysis from February 2016 to December 2017 of a prospective database conducted in 2 intensive care units (ICU). All patients with documented severe GNB infections treated with amikacin (single daily dose of 25 mg/kg of total body weight (TBW)) with both MIC and C 93 patients with 98 GNB-documented infections were included. The median C According to PK/PD parameters observed in our study, single daily dose of amikacin 25 mg/kg of TBW appears to be sufficient in most critically ill patients treated for severe GNB infections.
Sections du résumé
BACKGROUND
BACKGROUND
Aminoglycosides have a concentration-dependent therapeutic effect when peak serum concentration (C
METHODS
METHODS
Retrospective analysis from February 2016 to December 2017 of a prospective database conducted in 2 intensive care units (ICU). All patients with documented severe GNB infections treated with amikacin (single daily dose of 25 mg/kg of total body weight (TBW)) with both MIC and C
RESULTS
RESULTS
93 patients with 98 GNB-documented infections were included. The median C
CONCLUSION
CONCLUSIONS
According to PK/PD parameters observed in our study, single daily dose of amikacin 25 mg/kg of TBW appears to be sufficient in most critically ill patients treated for severe GNB infections.
Identifiants
pubmed: 32514769
doi: 10.1186/s13613-020-00685-5
pii: 10.1186/s13613-020-00685-5
pmc: PMC7276966
doi:
Types de publication
Journal Article
Langues
eng
Pagination
75Références
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