Combined Chemisorption and Complexation Generate siRNA Nanocarriers with Biophysics Optimized for Efficient Gene Knockdown and Air-Blood Barrier Crossing.
biodistribution
gold nanoparticle
intratracheal
linear polyethylenimine
pulmonary delivery
siRNA knockdown
tomographic optical imaging
Journal
ACS applied materials & interfaces
ISSN: 1944-8252
Titre abrégé: ACS Appl Mater Interfaces
Pays: United States
ID NLM: 101504991
Informations de publication
Date de publication:
08 Jul 2020
08 Jul 2020
Historique:
pubmed:
10
6
2020
medline:
2
3
2021
entrez:
10
6
2020
Statut:
ppublish
Résumé
Current nucleic acid (NA) nanotherapeutic approaches face challenges because of shortcomings such as limited control on loading efficiency, complex formulation procedure involving purification steps, low load of NA cargo per nanoparticle, endosomal trapping, and hampered release inside the cell. When combined, these factors significantly limit the amount of biologically active NA delivered per cell
Identifiants
pubmed: 32515194
doi: 10.1021/acsami.0c06608
pmc: PMC7467563
doi:
Substances chimiques
RNA, Small Interfering
0
Gold
7440-57-5
Polyethyleneimine
9002-98-6
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
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