Human Telomerase RNA: Telomerase Component or More?
alternative function
ribonucleoprotein particles
telomerase
telomere
Journal
Biomolecules
ISSN: 2218-273X
Titre abrégé: Biomolecules
Pays: Switzerland
ID NLM: 101596414
Informations de publication
Date de publication:
06 06 2020
06 06 2020
Historique:
received:
18
04
2020
revised:
04
06
2020
accepted:
05
06
2020
entrez:
11
6
2020
pubmed:
11
6
2020
medline:
13
4
2021
Statut:
epublish
Résumé
Telomerase is a ribonucleoprotein complex that maintains the lengths of telomeres. Most studies of telomerase function have focused on the involvement of telomerase activation in the immortalization of cancer cells and cellular rejuvenation. However, some studies demonstrated that the results do not meet expectations for telomerase action in telomere maintenance. Recent results give reason to think that major telomerase components-the reverse transcriptase protein subunit and telomerase RNA-may participate in many cellular processes, including the regulation of apoptosis and autophagy, cell survival, pro-proliferative effects, regulation of gene expression, and protection against oxidative stress. However, the difficulties faced by scientist when researching telomerase component functions often reduce confidence in the minor effects observed in experiments. In this review, we focus on the analysis of the functions of telomerase components (paying more attention to the telomerase RNA component), both as a complex and as independent components, providing effects that are not associated with telomerase activity and telomere length maintenance. Despite the fact that the data on alternative roles of telomerase components look illusory, it would be wrong to completely reject the possibility of their involvement in other biological processes excluded from research/discussion. Investigations to improve the understanding of every aspect of the functioning of telomerase components will provide the basis for a more precise development of approaches to regulate cellular homeostasis, which is important for carcinogenesis and aging.
Identifiants
pubmed: 32517215
pii: biom10060873
doi: 10.3390/biom10060873
pmc: PMC7355840
pii:
doi:
Substances chimiques
telomerase RNA
0
RNA
63231-63-0
Telomerase
EC 2.7.7.49
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Russian Science Foundation
ID : 19-14-00065
Pays : International
Organisme : Russian Foundation for Basic Research
ID : 18-29-07031 mk
Pays : International
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
Références
Front Cell Dev Biol. 2019 Dec 10;7:332
pubmed: 31911897
Nucleic Acids Res. 2002 Jan 15;30(2):592-7
pubmed: 11788723
J Exp Med. 1996 Jun 1;183(6):2471-9
pubmed: 8676067
Biochimie. 2003 Nov;85(11):1161-73
pubmed: 14726021
EMBO Rep. 2019 Feb;20(2):
pubmed: 30591524
DNA Repair (Amst). 2010 Dec 10;9(12):1249-55
pubmed: 21036674
Nature. 2003 Nov 13;426(6963):194-8
pubmed: 14608368
Genes (Basel). 2019 Apr 24;10(4):
pubmed: 31022960
Proc Natl Acad Sci U S A. 2011 Dec 20;108(51):20333-8
pubmed: 22123986
Dokl Akad Nauk SSSR. 1971;201(6):1496-9
pubmed: 5158754
Cell Rep. 2018 Sep 4;24(10):2589-2595
pubmed: 30184494
Elife. 2016 Aug 15;5:
pubmed: 27525486
Mol Cell Biol. 1996 Jul;16(7):3765-72
pubmed: 8668193
Mol Cell Biol. 2012 Jul;32(13):2428-39
pubmed: 22527283
Cell Growth Differ. 1998 Sep;9(9):805-13
pubmed: 9751124
J Biol Chem. 2010 Feb 12;285(7):4375-86
pubmed: 20022961
Cell. 2016 Aug 25;166(5):1188-1197.e9
pubmed: 27523609
Nucleic Acids Res. 2019 Sep 5;47(15):8084-8095
pubmed: 31294790
Biochem J. 2009 Feb 1;417(3):639-50
pubmed: 19133841
Blood. 2014 Dec 11;124(25):3675-84
pubmed: 25320237
RNA. 2009 Feb;15(2):235-43
pubmed: 19095616
Trends Biochem Sci. 2011 Mar;36(3):133-40
pubmed: 20947357
Science. 1994 Dec 23;266(5193):2011-5
pubmed: 7605428
Mol Cell Biol. 1991 Sep;11(9):4572-80
pubmed: 1875940
Proc Natl Acad Sci U S A. 2003 Jan 21;100(2):449-54
pubmed: 12525685
Cell Rep. 2015 Dec 15;13(10):2232-43
pubmed: 26628367
Mol Biol Cell. 2000 Mar;11(3):999-1010
pubmed: 10712515
Nature. 2009 Jul 2;460(7251):66-72
pubmed: 19571879
PLoS Genet. 2012;8(6):e1002747
pubmed: 22719262
Cell. 1985 Dec;43(2 Pt 1):405-13
pubmed: 3907856
Nat Struct Mol Biol. 2014 Jun;21(6):507-12
pubmed: 24793650
Nat Genet. 1996 Feb;12(2):200-4
pubmed: 8563761
Biochimie. 2008 Jan;90(1):122-30
pubmed: 17825470
Cell. 2018 Jun 28;174(1):218-230.e13
pubmed: 29804836
Oncotarget. 2016 Nov 29;7(48):78297-78309
pubmed: 27823970
Cell Rep. 2020 Feb 4;30(5):1358-1372.e5
pubmed: 32023455
Mol Cell. 2007 Sep 21;27(6):882-9
pubmed: 17889662
Nucleic Acids Res. 2018 Sep 28;46(17):8966-8977
pubmed: 30102362
Genome Biol. 2014 Jan 07;15(1):R6
pubmed: 24393600
Genes Dev. 2015 Jun 1;29(11):1095-105
pubmed: 26063571
Proc Natl Acad Sci U S A. 2007 May 1;104(18):7552-7
pubmed: 17460043
Nat Rev Genet. 2005 Aug;6(8):611-22
pubmed: 16136653
Curr Opin Struct Biol. 2019 Apr;55:185-193
pubmed: 31202023
Mol Cell Biol. 2011 Feb;31(4):736-43
pubmed: 21149580
Biochim Biophys Acta. 2009 Apr;1792(4):371-9
pubmed: 19419704
Mol Cell Biol. 1999 Jun;19(6):3989-97
pubmed: 10330139
Genes Dev. 2008 Jan 15;22(2):125-40
pubmed: 18198332
EMBO J. 2012 Jan 4;31(1):150-61
pubmed: 21989387
Science. 2009 Jan 30;323(5914):644-8
pubmed: 19179534
Nucleic Acids Res. 2018 Feb 16;46(3):1525-1540
pubmed: 29294091
J Exp Med. 2006 May 15;203(5):1307-17
pubmed: 16651385
Nucleic Acids Res. 2014 Jul;42(13):8565-77
pubmed: 24990373
Nature. 1989 Jan 26;337(6205):331-7
pubmed: 2463488
Proc Natl Acad Sci U S A. 1992 Nov 1;89(21):10114-8
pubmed: 1438199
J Virol. 2009 Oct;83(19):9844-53
pubmed: 19640998
Nat Struct Mol Biol. 2015 Nov;22(11):848-52
pubmed: 26581518
Immunity. 1996 Sep;5(3):207-16
pubmed: 8808676
J Cell Physiol. 1999 Jul;180(1):10-8
pubmed: 10362013
PLoS Pathog. 2010 Aug 26;6(8):e1001073
pubmed: 20865127
Mol Cell. 2009 Apr 10;34(1):47-57
pubmed: 19285445
Nucleic Acids Res. 2009 Oct;37(18):6105-15
pubmed: 19656952
Mol Cell. 2011 Nov 18;44(4):667-78
pubmed: 21963238
Cell. 1989 Nov 3;59(3):521-9
pubmed: 2805070
Cancer Res. 2014 Mar 15;74(6):1639-44
pubmed: 24599132
Mol Cell. 2000 Aug;6(2):361-71
pubmed: 10983983
Cell. 1987 Dec 24;51(6):887-98
pubmed: 3319189
J Virol. 2003 May;77(10):5985-96
pubmed: 12719590
EMBO J. 1991 Feb;10(2):459-66
pubmed: 1846807
Nat Struct Mol Biol. 2016 Apr;23(4):286-92
pubmed: 26950371
Sci Rep. 2019 Feb 8;9(1):1701
pubmed: 30737432
RNA Biol. 2016 Aug 2;13(8):720-32
pubmed: 27359343
EMBO Rep. 2005 Mar;6(3):268-74
pubmed: 15731767
Clin Cancer Res. 2003 Oct 15;9(13):4705-13
pubmed: 14581340
J Biol Chem. 2006 Dec 29;281(52):40503-14
pubmed: 17098743
J Biol Chem. 2005 Jun 24;280(25):23709-17
pubmed: 15831499
Nature. 2018 May;557(7704):190-195
pubmed: 29695869
Cell. 2013 Jul 3;154(1):240-51
pubmed: 23810193
BMC Mol Biol. 2013 Sep 21;14:23
pubmed: 24053768
Nat Commun. 2014;5:3228
pubmed: 24496182