Emerin Phosphorylation during the Early Phase of the Oxidative Stress Response Influences Emerin-BAF Interaction and BAF Nuclear Localization.
Cell Nucleus
/ metabolism
DNA Damage
DNA-Binding Proteins
/ metabolism
HEK293 Cells
HeLa Cells
Humans
Lamin Type A
/ deficiency
Membrane Proteins
/ metabolism
Molecular Weight
Muscular Dystrophy, Emery-Dreifuss
/ pathology
Nuclear Proteins
/ metabolism
Oxidative Stress
Phosphorylation
Protein Binding
Protein Transport
Reactive Oxygen Species
/ metabolism
BAF
BANF1
DNA-damage response
EDMD1
chromatin
emerin
laminA/C
laminopathies
oxidative stress
prelamin A
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
06 06 2020
06 06 2020
Historique:
received:
19
05
2020
revised:
04
06
2020
accepted:
04
06
2020
entrez:
11
6
2020
pubmed:
11
6
2020
medline:
3
3
2021
Statut:
epublish
Résumé
Reactive Oxygen Species (ROS) are reactive molecules required for the maintenance of physiological functions. Oxidative stress arises when ROS production exceeds the cellular ability to eliminate such molecules. In this study, we showed that oxidative stress induces post-translational modification of the inner nuclear membrane protein emerin. In particular, emerin is phosphorylated at the early stages of the oxidative stress response, while protein phosphorylation is abolished upon recovery from stress. A finely tuned balance between emerin phosphorylation and
Identifiants
pubmed: 32517247
pii: cells9061415
doi: 10.3390/cells9061415
pmc: PMC7349582
pii:
doi:
Substances chimiques
BANF1 protein, human
0
DNA-Binding Proteins
0
Lamin Type A
0
Membrane Proteins
0
Nuclear Proteins
0
Reactive Oxygen Species
0
emerin
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
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