Risk factors associated with the detection of pulmonary emphysema in older asymptomatic respiratory subjects.
Aged
Aged, 80 and over
Aging
Case-Control Studies
Cigarette Smoking
/ adverse effects
Female
Glucuronidase
/ blood
Humans
Klotho Proteins
Logistic Models
Lung
/ physiopathology
Male
Middle Aged
Multivariate Analysis
Pulmonary Emphysema
/ blood
Respiratory Function Tests
Risk Factors
Telomere
/ physiology
Tomography, X-Ray Computed
Aging
COPD
Klotho
Pulmonary emphysema
Risk factors
Telomere length
Journal
BMC pulmonary medicine
ISSN: 1471-2466
Titre abrégé: BMC Pulm Med
Pays: England
ID NLM: 100968563
Informations de publication
Date de publication:
09 Jun 2020
09 Jun 2020
Historique:
received:
28
02
2020
accepted:
01
06
2020
entrez:
11
6
2020
pubmed:
11
6
2020
medline:
9
3
2021
Statut:
epublish
Résumé
Several lung structural and functional abnormalities may occur associated with aging, including emphysema. In this study, we evaluated the frequency and risk factors associated with emphysema in respiratory asymptomatic individuals enrolled in our Lung Aging Program. From a cohort of 687 subjects, we found by high-resolution computed tomography (HRCT) 29 individuals (4%) with emphysematous changes that were compared with 87 controls (3:1) randomly selected from the same cohort. This was a transversal, observational, case-control study where we examined demographics and functional characteristics, as well as telomere length and serum Klotho concentration, two conditions that have been associated with aging and some aging-associated diseases including emphysema. Individuals with subclinical pulmonary emphysema were older (72 ± 9 versus 67 ± 6 years), and primarily smoker males with low body mass index. Despite that they were asymptomatic, two of them exhibited a decrease of forced expiratory volume in 1 s (FEV Our findings reveal that a small but important percentage of older people without respiratory symptoms, present pulmonary emphysema and indicate that smoking exposure and genetic background may contribute to etiological factors.
Sections du résumé
BACKGROUND
BACKGROUND
Several lung structural and functional abnormalities may occur associated with aging, including emphysema. In this study, we evaluated the frequency and risk factors associated with emphysema in respiratory asymptomatic individuals enrolled in our Lung Aging Program. From a cohort of 687 subjects, we found by high-resolution computed tomography (HRCT) 29 individuals (4%) with emphysematous changes that were compared with 87 controls (3:1) randomly selected from the same cohort.
METHODS
METHODS
This was a transversal, observational, case-control study where we examined demographics and functional characteristics, as well as telomere length and serum Klotho concentration, two conditions that have been associated with aging and some aging-associated diseases including emphysema.
RESULTS
RESULTS
Individuals with subclinical pulmonary emphysema were older (72 ± 9 versus 67 ± 6 years), and primarily smoker males with low body mass index. Despite that they were asymptomatic, two of them exhibited a decrease of forced expiratory volume in 1 s (FEV
CONCLUSION
CONCLUSIONS
Our findings reveal that a small but important percentage of older people without respiratory symptoms, present pulmonary emphysema and indicate that smoking exposure and genetic background may contribute to etiological factors.
Identifiants
pubmed: 32517728
doi: 10.1186/s12890-020-01204-9
pii: 10.1186/s12890-020-01204-9
pmc: PMC7285611
doi:
Substances chimiques
Glucuronidase
EC 3.2.1.31
Klotho Proteins
EC 3.2.1.31
Types de publication
Journal Article
Observational Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
164Subventions
Organisme : Secretaría de Educación, Ciencia, Tecnología e Innovación de la Ciudad de Mexico
ID : SECITI/115/2017
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