Epidemiology of the classical myeloproliferative neoplasms: The four corners of an expansive and complex map.

Animals Hematologic Neoplasms / diagnosis Humans Incidence Myeloproliferative Disorders / diagnosis Prognosis Risk Factors Survival Analysis
Epidemiology Etiology Incidence MPN Mortality Myeloproliferative Survival

Journal

Blood reviews
ISSN: 1532-1681
Titre abrégé: Blood Rev
Pays: England
ID NLM: 8708558

Informations de publication

Date de publication:
07 2020
Historique:
received: 21 10 2019
revised: 02 03 2020
accepted: 08 05 2020
pubmed: 11 6 2020
medline: 20 1 2021
entrez: 11 6 2020
Statut: ppublish

Résumé

The classical myeloproliferative neoplasms (MPNs), specifically chronic myeloid leukemia (CML), polycythemia vera (PV), essential thrombocythemia (ET) and primary myelofibrosis (PMF), represent clonal myeloid disorders whose pathogenesis is driven by well-defined molecular abnormalities. In this comprehensive review, we summarize the epidemiological literature and present our own analysis of the most recent the Surveillance, Epidemiology, and End Results (SEER) program data through 2016. Older age and male gender are known risk factors for MPNs, but the potential etiological role of other variables is less established. The incidences of CML, PV, and ET are relatively similar at 1.0-2.0 per 100,000 person-years in the United States, while PMF is rarer with an incidence of 0.3 per 100,000 person-years. The availability of tyrosine kinase inhibitor therapy has dramatically improved CML patient outcomes and yield a life expectancy similar to the general population. Patients with PV or ET have better survival than PMF patients.

Identifiants

DOI: 10.1016/j.blre.2020.100706 PMID: 32517877
pubmed: 32517877
pii: S0268-960X(20)30056-4
doi: 10.1016/j.blre.2020.100706
pii:
doi:

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

100706

Subventions

Organisme : NCI NIH HHS
ID : P30 CA016359
Pays : United States

Informations de copyright

Copyright © 2020 Elsevier Ltd. All rights reserved.

Auteurs

Rory M Shallis (RM)

Section of Hematology, Department of Internal Medicine, Yale University School of Medicine, New Haven, USA.

Rong Wang (R)

Cancer Outcomes, Public Policy, and Effectiveness Research (COPPER) Center, Yale University, New Haven, USA; Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, USA.

Amy Davidoff (A)

Cancer Outcomes, Public Policy, and Effectiveness Research (COPPER) Center, Yale University, New Haven, USA; Department of Health Policy and Management, Yale School of Public Health, New Haven, USA.

Xiaomei Ma (X)

Cancer Outcomes, Public Policy, and Effectiveness Research (COPPER) Center, Yale University, New Haven, USA; Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, USA.

Nikolai A Podoltsev (NA)

Section of Hematology, Department of Internal Medicine, Yale University School of Medicine, New Haven, USA; Cancer Outcomes, Public Policy, and Effectiveness Research (COPPER) Center, Yale University, New Haven, USA.

Amer M Zeidan (AM)

Section of Hematology, Department of Internal Medicine, Yale University School of Medicine, New Haven, USA; Cancer Outcomes, Public Policy, and Effectiveness Research (COPPER) Center, Yale University, New Haven, USA. Electronic address: amer.zeidan@yale.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Epidemiology of the classical...
questionsmedicales.fr › Hémopathies et maladies lymphatiques › Hémopathies › Tumeurs hématologiques › Epidemiology of the classical...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Epidemiology of the classical...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Collecte de données › Registre civil › Morbidité › Incidence › Epidemiology of the classical...
questionsmedicales.fr › Hémopathies et maladies lymphatiques › Hémopathies › Maladies de la moelle osseuse › Syndromes myéloprolifératifs › Epidemiology of the classical...
questionsmedicales.fr › Diagnostic › Pronostic › Epidemiology of the classical...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Probabilité › Risque › Facteurs de risque › Epidemiology of the classical...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Analyse de survie › Epidemiology of the classical...