The mitochondrial metal transporters mitoferrin1 and mitoferrin2 are required for liver regeneration and cell proliferation in mice.
Slc25a28
cell proliferation
gene knockout
iron metabolism
liver
membrane transport
metal homeostasis
mitochondria
mitoferrin (Mfrn)
solute carrier family 25 member 37 (Slc25a37)
Journal
The Journal of biological chemistry
ISSN: 1083-351X
Titre abrégé: J Biol Chem
Pays: United States
ID NLM: 2985121R
Informations de publication
Date de publication:
07 08 2020
07 08 2020
Historique:
received:
26
02
2020
revised:
04
06
2020
pubmed:
11
6
2020
medline:
20
2
2021
entrez:
11
6
2020
Statut:
ppublish
Résumé
Mitochondrial iron import is essential for iron-sulfur cluster formation and heme biosynthesis. Two nuclear-encoded vertebrate mitochondrial high-affinity iron importers, mitoferrin1 (Mfrn1) and Mfrn2, have been identified in mammals. In mice, the gene encoding Mfrn1,
Identifiants
pubmed: 32518166
pii: S0021-9258(17)49200-3
doi: 10.1074/jbc.RA120.013229
pmc: PMC7415990
doi:
Substances chimiques
Cation Transport Proteins
0
Membrane Transport Proteins
0
Slc25a28 protein, mouse
0
mitoferrin protein, mouse
0
Iron
E1UOL152H7
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
11002-11020Subventions
Organisme : NIDDK NIH HHS
ID : R01 DK092684
Pays : United States
Organisme : NIDDK NIH HHS
ID : U54 DK106829
Pays : United States
Organisme : NHLBI NIH HHS
ID : P01 HL032262
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK070838
Pays : United States
Organisme : NIDDK NIH HHS
ID : U54 DK110858
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK073462
Pays : United States
Informations de copyright
© 2020 Seguin et al.
Déclaration de conflit d'intérêts
Conflict of interest—The authors declare no competing interests.
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