Anaesthetic-dependent changes in gene expression following acute and chronic exposure in the rodent brain.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
09 06 2020
09 06 2020
Historique:
received:
29
11
2019
accepted:
13
05
2020
entrez:
11
6
2020
pubmed:
11
6
2020
medline:
15
12
2020
Statut:
epublish
Résumé
Anaesthesia has been predicted to affect gene expression of the memory-related regions of the brain including the primary visual cortex. It is also believed that anaesthesia causes inflammation of neural tissues, increasing elderly patients' chances of developing precursor lesions that lead to Alzheimer's disease and other neurodegeneration related diseases. We have analyzed the expression of over 22,000 genes and 129,800 transcripts using oligonucleotide microarrays to examine the brain expression profiles in Sprague Dawley rats following exposure to acute or chronic doses of the anaesthetics isoflurane, ketamine and propofol. Here we report for the first time molecular and genomic data on the effect on the rodent brain of chronic and acute exposure to isoflurane, ketamine and propofol. Our screen identified multiple genes that responded to all three anaesthetics. Although some of the genes were previously known to be anaesthesia responsive, we have for the most part identified novel genes involved in the acute and chronic rodent brain response to different anaesthesia treatments. The latter may be useful candidate genes in the search to elucidate the molecular pathways mediating anaesthetic effects in the brain and may allow us to identify mechanisms by which anaesthetics could impact on neurodegeneration.
Identifiants
pubmed: 32518252
doi: 10.1038/s41598-020-66122-6
pii: 10.1038/s41598-020-66122-6
pmc: PMC7283325
doi:
Substances chimiques
Anesthetics, General
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
9366Références
Front Behav Neurosci. 2016 Jan 12;9:363
pubmed: 26793081
Curr Drug Saf. 2009 Jan;4(1):11-6
pubmed: 19149520
J Neurosci. 2005 Feb 23;25(8):1935-42
pubmed: 15728833
Eur J Neurosci. 2013 Jun;37(11):1875-84
pubmed: 23431968
Anesthesiology. 2008 Feb;108(2):251-60
pubmed: 18212570
J Neurosci. 2000 Sep 15;20(18):7116-21
pubmed: 10995859
Curr Med Chem. 2000 Feb;7(2):249-71
pubmed: 10637364
Learn Mem. 2012 Nov 16;19(12):588-92
pubmed: 23161447
Biochem Pharmacol. 2001 Aug 1;62(3):375-82
pubmed: 11434912
Anesthesiology. 2004 Oct;101(4):912-7
pubmed: 15448524
Brain Res. 2011 Mar 24;1381:124-33
pubmed: 21241667
J Neurosurg Anesthesiol. 2002 Jan;14(1):66-79
pubmed: 11773828
Cell Rep. 2016 Aug 23;16(8):2116-2128
pubmed: 27524619
J Neurosci. 2001 Jul 15;21(14):5089-98
pubmed: 11438584
Neuroscience. 2010 Mar 31;166(3):852-63
pubmed: 20080153
Anesthesiology. 2004 Sep;101(3):703-9
pubmed: 15329595
Anesth Prog. 2001 Spring;48(2):66-71
pubmed: 11515950
Neurosci Lett. 2012 Oct 24;528(2):210-4
pubmed: 22884934
Nature. 2014 Feb 13;506(7487):179-84
pubmed: 24463507
Cell. 1993 Dec 17;75(6):1199-214
pubmed: 7903221
Endocrinol Metab (Seoul). 2013 Dec;28(4):288-96
pubmed: 24396694
Toxicol Sci. 2007 Jul;98(1):145-58
pubmed: 17426105
J Thromb Haemost. 2005 Jul;3(7):1379-84
pubmed: 15978095
Anesthesiology. 2009 Oct;111(4):741-52
pubmed: 19741497
J Biol Chem. 2008 May 2;283(18):11866-75
pubmed: 18326038
Neurobiol Aging. 2008 Jul;29(7):1002-10
pubmed: 17346857
Nat Neurosci. 1999 Dec;2(12):1120-4
pubmed: 10570490
Cell Death Dis. 2013 Apr 18;4:e595
pubmed: 23598407
Chin Med J (Engl). 2015 Jun 5;128(11):1510-5
pubmed: 26021509
J Microsc. 1998 Sep;191(3):238-248
pubmed: 9767488
Neuropsychopharmacology. 1997 Sep;17(3):141-50
pubmed: 9272481
J Neuroinflammation. 2012 Jun 29;9:149
pubmed: 22747686
Proc Natl Acad Sci U S A. 1998 May 26;95(11):6355-60
pubmed: 9600969
Cell Physiol Biochem. 2014;33(6):1715-32
pubmed: 24923288
Neuron. 2006 Nov 9;52(3):437-44
pubmed: 17088210
Sci Rep. 2016 Nov 23;6:37713
pubmed: 27876882
Brain Res Mol Brain Res. 2000 Mar 10;76(1):18-24
pubmed: 10719211
Trends Pharmacol Sci. 2005 Oct;26(10):503-10
pubmed: 16126282
Nature. 1999 Sep 16;401(6750):272-6
pubmed: 10499584
Learn Mem. 2006 Mar-Apr;13(2):135-42
pubmed: 16547164
J Neurosurg Anesthesiol. 2010 Apr;22(2):144-54
pubmed: 20118798
Anesth Analg. 2013 Mar;116(3):589-95
pubmed: 23400992
Genes Dev. 1993 Nov;7(11):2071-84
pubmed: 8224839
Nature. 2014 Feb 13;506(7487):185-90
pubmed: 24463508
Mol Med Rep. 2015 Dec;12(6):8071-6
pubmed: 26497548
Exp Brain Res. 2010 Jan;200(2):125-40
pubmed: 19690847
Mol Cell Neurosci. 2002 Dec;21(4):634-44
pubmed: 12504596
EMBO Rep. 2014 Nov;15(11):1113-8
pubmed: 25312808
Development. 1996 Jan;122(1):113-20
pubmed: 8565822
Neuron. 2006 Nov 9;52(3):475-84
pubmed: 17088213
Anesth Analg. 1998 Nov;87(5):1186-93
pubmed: 9806706
Neural Regen Res. 2017 Aug;12(8):1329-1337
pubmed: 28966649
J Neurochem. 2012 Feb;120(3):453-60
pubmed: 22097881
Nature. 1994 Feb 17;367(6464):607-14
pubmed: 7509043
FASEB J. 2009 Aug;23(8):2595-604
pubmed: 19279139
Nature. 1994 Oct 27;371(6500):796-9
pubmed: 7935840
EMBO J. 1997 Jan 15;16(2):221-9
pubmed: 9029143
Mol Med Rep. 2014 May;9(5):1715-22
pubmed: 24626427
Anesthesiology. 2002 May;96(5):1183-90
pubmed: 11981160
Biochim Biophys Acta. 2008 Nov;1778(11):2633-9
pubmed: 18639516
Mol Neurobiol. 2010 Oct;42(2):124-32
pubmed: 20514530
Neuroscience. 2003;117(1):147-56
pubmed: 12605901
Cell. 2011 Oct 28;147(3):615-28
pubmed: 22036569
Neurochem Res. 2011 Oct;36(10):1724-31
pubmed: 21556843
Anesth Analg. 1999 Nov;89(5):1250-6
pubmed: 10553845
J Neurosci. 2003 Feb 1;23(3):876-82
pubmed: 12574416
PLoS One. 2011 Jan 31;6(1):e16648
pubmed: 21304998
J Alzheimers Dis. 2009;16(3):619-26
pubmed: 19276556
Nat Neurosci. 2011 Mar;14(3):279-84
pubmed: 21278731
Curr Neuropharmacol. 2011 Mar;9(1):256-61
pubmed: 21886601
Front Mol Neurosci. 2017 Jul 28;10:234
pubmed: 28804447
Ann Neurol. 2008 Dec;64(6):618-27
pubmed: 19006075
Neuron. 2008 Jul 10;59(1):70-83
pubmed: 18614030
Blood. 2008 Jul 1;112(1):179-87
pubmed: 18314442
Neuropsychopharmacology. 2001 Oct;25(4):455-67
pubmed: 11557159
Anesthesiology. 1988 Sep;69(3):348-56
pubmed: 3261954
Genome Biol. 2010;11(5):R48
pubmed: 20459597
Toxicol Sci. 2009 Mar;108(1):149-58
pubmed: 19126600
Neuron. 2006 Nov 9;52(3):445-59
pubmed: 17088211
PLoS One. 2009;4(4):e5292
pubmed: 19390590
BMC Res Notes. 2010 Jul 17;3:201
pubmed: 20637119
Ann Emerg Med. 2009 Aug;54(2):181-90
pubmed: 18990467
Front Neurosci. 2008 Jul 07;2(1):47-55
pubmed: 18982106
Anesth Analg. 2000 May;90(5):1177-83
pubmed: 10781476
Anesthesiology. 1999 Jul;91(1):187-97
pubmed: 10422944
Nature. 1998 Nov 26;396(6709):324
pubmed: 9845069
PLoS One. 2013 May 30;8(5):e64480
pubmed: 23737984
Science. 2000 Feb 11;287(5455):1056-60
pubmed: 10669420
Science. 2011 Dec 23;334(6063):1669-75
pubmed: 22194569
Br J Pharmacol. 2010 Sep;161(2):288-307
pubmed: 20735416
Eur J Anaesthesiol. 1997 May;14(3):320-6
pubmed: 9202922
Anesthesiology. 2000 Sep;93(3):805-10
pubmed: 10969314
Circ Res. 2007 Feb 16;100(3):372-80
pubmed: 17234971
Neurobiol Learn Mem. 2000 Sep;74(2):161-78
pubmed: 10933901
J Pharmacol Exp Ther. 2006 Jan;316(1):315-24
pubmed: 16192313
Arch Neurol. 2009 May;66(5):620-31
pubmed: 19433662
Anesthesiology. 1999 May;90(5):1446-53
pubmed: 10319794
J Anim Sci. 2008 Nov;86(11):2897-902
pubmed: 18641171
Int J Dev Neurosci. 2009 May;27(3):279-87
pubmed: 19150648
Kidney Int. 2002 Nov;62(5):1601-10
pubmed: 12371960
Front Behav Neurosci. 2007 Dec 30;1:6
pubmed: 18958188
Nat Neurosci. 2010 Apr;13(4):450-7
pubmed: 20228806
Br J Anaesth. 1996 Oct;77(4):441-4
pubmed: 8942324
Science. 1999 Jan 1;283(5398):70-4
pubmed: 9872743
Cell. 2010 Mar 5;140(5):704-16
pubmed: 20211139
Brain Res Bull. 2011 Apr 25;85(1-2):21-9
pubmed: 21316423