Transplanting neural progenitor cells to restore connectivity after spinal cord injury.
Journal
Nature reviews. Neuroscience
ISSN: 1471-0048
Titre abrégé: Nat Rev Neurosci
Pays: England
ID NLM: 100962781
Informations de publication
Date de publication:
07 2020
07 2020
Historique:
accepted:
30
04
2020
pubmed:
11
6
2020
medline:
15
12
2020
entrez:
11
6
2020
Statut:
ppublish
Résumé
Spinal cord injury remains a scientific and therapeutic challenge with great cost to individuals and society. The goal of research in this field is to find a means of restoring lost function. Recently we have seen considerable progress in understanding the injury process and the capacity of CNS neurons to regenerate, as well as innovations in stem cell biology. This presents an opportunity to develop effective transplantation strategies to provide new neural cells to promote the formation of new neuronal networks and functional connectivity. Past and ongoing clinical studies have demonstrated the safety of cell therapy, and preclinical research has used models of spinal cord injury to better elucidate the underlying mechanisms through which donor cells interact with the host and thus increase long-term efficacy. While a variety of cell therapies have been explored, we focus here on the use of neural progenitor cells obtained or derived from different sources to promote connectivity in sensory, motor and autonomic systems.
Identifiants
pubmed: 32518349
doi: 10.1038/s41583-020-0314-2
pii: 10.1038/s41583-020-0314-2
pmc: PMC8384139
mid: NIHMS1732846
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
366-383Subventions
Organisme : NINDS NIH HHS
ID : P01 NS055976
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS104291
Pays : United States
Commentaires et corrections
Type : CommentIn
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