A Controlled Study on Efficacy and Egg Reappearance Period of Ivermectin in Donkeys Naturally Infected with Small Strongyles.
donkeys
efficacy
egg reappearance period
ivermectin
small strongyles
Journal
Helminthologia
ISSN: 0440-6605
Titre abrégé: Helminthologia
Pays: Germany
ID NLM: 0043764
Informations de publication
Date de publication:
01 Jun 2020
01 Jun 2020
Historique:
received:
04
10
2019
accepted:
09
01
2020
entrez:
11
6
2020
pubmed:
11
6
2020
medline:
11
6
2020
Statut:
epublish
Résumé
The aim of the present study was to investigate the efficacy and the egg reappearance period (ERP) of ivermectin (IVM) in donkeys during a 13-week period. The study involved a total of 14 adult Amiata breed donkeys, 7 - 13 years of age, and naturally infected with small strongyles. A group of 10 donkeys was treated with IVM oral paste at a dose rate of 200 mcg/kg BW. Another group of 4 donkeys was kept as untreated control group. Faecal samples were collected and examined for strongyle eggs on day 0 before treatment. IVM efficacy was based on the faecal egg count reduction test (FECRT) on day 14 post-treatment. Then individual faecal samples were collected and examined by FECRT at weekly intervals. A FECRT of 100 % was found after treatment with IVM and its ERP, defined as the week when the mean FECRT decreased until to become lower than 90 %efficacy, was estimated to be 11 weeks without signs of developing anthelmintic resistance. No adverse reactions were observed during the study period. Our findings may be useful to veterinary practitioners and breeders as they show that IVM, at the recommended dose rate, can be still considered a highly effective and safe pharmacological tool for the treatment of small strongyles in donkeys. Therefore, it is strongly recommended that all possible strategies are undertaken to avoid the risk of emergence of anthelmintic resistance to IVM in donkeys.
Identifiants
pubmed: 32518493
doi: 10.2478/helm-2020-0017
pii: helm-2020-0017
pmc: PMC7261031
doi:
Types de publication
Journal Article
Langues
eng
Pagination
163-170Informations de copyright
© 2020 R. A. Papini, C. Orsetti, M. Sgorbini, published by Sciendo.
Déclaration de conflit d'intérêts
Conflict of Interest Authors state no conflict of interest.
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