Role of immune cells in the removal of deleterious senescent cells.
Age-related pathology
Cell-based therapy
Cellular senescence
Immune surveillance
Inflammation
Macrophages
Natural killer cells
Journal
Immunity & ageing : I & A
ISSN: 1742-4933
Titre abrégé: Immun Ageing
Pays: England
ID NLM: 101235427
Informations de publication
Date de publication:
2020
2020
Historique:
received:
16
02
2020
accepted:
18
05
2020
entrez:
11
6
2020
pubmed:
11
6
2020
medline:
11
6
2020
Statut:
epublish
Résumé
Cellular senescence is an essentially irreversible arrest of cell proliferation coupled to a complex senescence-associated secretory phenotype (SASP). The senescence arrest prevents the development of cancer, and the SASP can promote tissue repair. Recent data suggest that the prolonged presence of senescent cells, and especially the SASP, could be deleterious, and their beneficial effects early in life can become maladaptive such that they drive aging phenotypes and pathologies late in life. It is therefore important to develop strategies to eliminate senescent cells. There are currently under development or approved several immune cell-based therapies for cancer, which could be redesigned to target senescent cells. This review focuses on this possible use of immune cells and discusses how current cell-based therapies could be used for senescent cell removal.
Identifiants
pubmed: 32518575
doi: 10.1186/s12979-020-00187-9
pii: 187
pmc: PMC7271494
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
16Informations de copyright
© The Author(s) 2020.
Déclaration de conflit d'intérêts
Competing interestsNone.
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