Molecular characterisation of ILRUN, a novel inhibitor of proinflammatory and antimicrobial cytokines.
Biochemistry
Biomolecules
C6orf106
CBP
ILRUN
Immune response
Immunolgy
Infectious disease
Inflammation
Innate immunity
Interferon
Viruses
p300
Journal
Heliyon
ISSN: 2405-8440
Titre abrégé: Heliyon
Pays: England
ID NLM: 101672560
Informations de publication
Date de publication:
Jun 2020
Jun 2020
Historique:
received:
28
01
2020
revised:
28
04
2020
accepted:
28
05
2020
entrez:
11
6
2020
pubmed:
11
6
2020
medline:
11
6
2020
Statut:
epublish
Résumé
Regulation of type-I interferon (IFN) production is essential to the balance between antimicrobial defence and autoimmune disorders. The human protein-coding gene ILRUN (inflammation and lipid regulator with UBA-like and NBR1-like domains, previously C6orf106) was recently characterised as an inhibitor of antiviral and proinflammatory cytokine (interferon-alpha/beta and tumor necrosis factor alpha) transcription. Currently there is a paucity of information about the molecular characteristics of ILRUN, despite it being associated with several diseases including virus infection, coronary artery disease, obesity and cancer. Here, we characterise ILRUN as a highly phylogenetically conserved protein containing UBA-like and a NBR1-like domains that are both essential for inhibition of type-I interferon and tumor necrosis factor alpha) transcription in human cells. We also solved the crystal structure of the NBR1-like domain, providing insights into its potential role in ILRUN function. This study provides critical information for future investigations into the role of ILRUN in health and disease.
Identifiants
pubmed: 32518853
doi: 10.1016/j.heliyon.2020.e04115
pii: S2405-8440(20)30959-2
pii: e04115
pmc: PMC7270589
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e04115Informations de copyright
Crown Copyright © 2020 Published by Elsevier Ltd.
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