Host glycan utilization within the Bacteroidetes Sus-like paradigm.
Bacteroides
N-linked glycans
gut microbiota
heparin
mucin
Journal
Glycobiology
ISSN: 1460-2423
Titre abrégé: Glycobiology
Pays: England
ID NLM: 9104124
Informations de publication
Date de publication:
29 06 2021
29 06 2021
Historique:
received:
27
04
2020
revised:
29
05
2020
accepted:
30
05
2020
pubmed:
11
6
2020
medline:
1
4
2022
entrez:
11
6
2020
Statut:
ppublish
Résumé
The Bacteroidetes are numerically abundant Gram-negative organisms of the distal human gut with a greatly expanded capacity to degrade complex glycans. A subset of these are adept at scavenging host glycans within this environment, including mucin O-linked glycans, N-linked glycoproteins and highly sulfated glycosaminoglycans (GAGs) such as heparin (Hep) and chondroitin sulfate (CS). Several recent biochemical studies have revealed the specific polysaccharide utilization loci (PULs) within the model symbiont Bacteroides thetaiotaomicron for the deconstruction of these host glycans. Here we discuss the Sus-like paradigm that defines glycan uptake by the Bacteroidetes and the salient details of the PULs that target heparin/heparan sulfate (HS) and chondroitin sulfate/dermatan sulfate (DS)/hyaluronic acid (HA), respectively, in B. thetaiotaomicron. The ability of the Bacteroidetes to target highly sulfated host glycans is key to their success in the gut environment but can lead to inflammation in susceptible hosts. Therefore, our continued understanding of the molecular strategies employed by these bacteria to scavenge carbohydrate nutrition is likely to lead to novel ways to alter their metabolism to promote host health.
Identifiants
pubmed: 32518945
pii: 5851810
doi: 10.1093/glycob/cwaa054
pmc: PMC8252860
doi:
Substances chimiques
Glycosaminoglycans
0
Polysaccharides
0
Heparitin Sulfate
9050-30-0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
697-706Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM118475
Pays : United States
Organisme : NIH HHS
ID : R01 GM118475
Pays : United States
Informations de copyright
© The Author(s) 2020. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
Références
Proc Natl Acad Sci U S A. 2017 Jul 3;114(27):7037-7042
pubmed: 28630303
Cell Mol Life Sci. 2021 Jan;78(2):675-693
pubmed: 32333083
mBio. 2014 Sep 09;5(5):e01441-14
pubmed: 25205092
Nat Microbiol. 2019 Sep;4(9):1571-1581
pubmed: 31160824
Nat Commun. 2020 Feb 14;11(1):899
pubmed: 32060313
J Bacteriol. 1996 Dec;178(24):7180-6
pubmed: 8955400
PLoS Biol. 2011 Dec;9(12):e1001221
pubmed: 22205877
Nucleic Acids Res. 2019 Jan 8;47(D1):D427-D432
pubmed: 30357350
J Biol Chem. 2018 Nov 16;293(46):17906-17916
pubmed: 30262663
Nature. 2017 Jan 19;541(7637):407-411
pubmed: 28077872
J Bacteriol. 1996 Dec;178(24):7173-9
pubmed: 8955399
Nature. 2012 Jun 13;486(7402):207-14
pubmed: 22699609
Cell Host Microbe. 2011 Nov 17;10(5):507-14
pubmed: 22036470
Nat Med. 2019 Jul;25(7):1096-1103
pubmed: 31263284
J Biol Chem. 2014 Aug 29;289(35):24289-303
pubmed: 25002587
J Bacteriol. 2001 Dec;183(24):7224-30
pubmed: 11717282
Handb Exp Pharmacol. 2012;(207):159-76
pubmed: 22566225
J Biol Chem. 2009 Dec 4;284(49):34019-27
pubmed: 19801541
Nat Rev Microbiol. 2012 Apr 11;10(5):323-35
pubmed: 22491358
Chem Commun (Camb). 2009 May 14;(18):2484-6
pubmed: 19532864
Mol Microbiol. 2018 Jun;108(5):551-566
pubmed: 29528148
J Clin Invest. 2011 Apr;121(4):1657-66
pubmed: 21383503
Biosci Biotechnol Biochem. 2012;76(5):1022-4
pubmed: 22738979
Annu Rev Microbiol. 2017 Sep 8;71:349-369
pubmed: 28657886
Biochemistry. 2009 Feb 24;48(7):1532-42
pubmed: 19191477
J Bacteriol. 1999 Dec;181(23):7206-11
pubmed: 10572122
Proc Natl Acad Sci U S A. 2019 Mar 26;116(13):6063-6068
pubmed: 30850540
Cell Host Microbe. 2015 May 13;17(5):672-80
pubmed: 25974305
Nat Chem Biol. 2010 Feb;6(2):125-32
pubmed: 20081828
J Bacteriol. 1997 Feb;179(3):643-9
pubmed: 9006015
J Bacteriol. 2017 Jul 11;199(15):
pubmed: 28138099
Nat Microbiol. 2018 Feb;3(2):210-219
pubmed: 29255254
PLoS Biol. 2013;11(8):e1001637
pubmed: 23976882
Dig Dis Sci. 2020 Mar;65(3):723-740
pubmed: 32060812
Nature. 2014 Jan 23;505(7484):559-63
pubmed: 24336217
Curr Opin Chem Biol. 2018 Dec;47:126-133
pubmed: 30326425
Mol Microbiol. 2013 Jun;88(5):876-90
pubmed: 23646867
Nat Commun. 2020 Jan 31;11(1):646
pubmed: 32005816
Nature. 2017 Apr 6;544(7648):65-70
pubmed: 28329766
Science. 2005 Mar 25;307(5717):1955-9
pubmed: 15790854
J Mol Biol. 2016 Aug 14;428(16):3230-3252
pubmed: 27393306
J Biol Chem. 2006 Aug 11;281(32):22464-70
pubmed: 16766528
Nat Commun. 2015 Sep 22;6:8292
pubmed: 26392213
Structure. 2010 Feb 10;18(2):200-15
pubmed: 20159465
Proc Natl Acad Sci U S A. 2017 Jan 31;114(5):E679-E688
pubmed: 28096352
Acta Crystallogr D Struct Biol. 2018 May 1;74(Pt 5):394-404
pubmed: 29717710
mBio. 2017 Oct 10;8(5):
pubmed: 29018117
Protein Cell. 2012 Dec;3(12):950-61
pubmed: 23011846
Glycobiology. 2017 Jan;27(2):176-187
pubmed: 27621378
Glycobiology. 2019 Dec 12;30(1):49-57
pubmed: 31701135
Glycobiology. 2008 Mar;18(3):270-7
pubmed: 18227125
Nature. 2014 May 15;509(7500):357-60
pubmed: 24739969
J Biol Chem. 2011 Jul 22;286(29):25973-82
pubmed: 21507958
J Biol Chem. 2015 Oct 9;290(41):25023-33
pubmed: 26286752
J Bacteriol. 1989 Jun;171(6):3199-204
pubmed: 2722748
Cell Host Microbe. 2008 Nov 13;4(5):447-57
pubmed: 18996345
Cell. 2016 Nov 17;167(5):1339-1353.e21
pubmed: 27863247
Nat Rev Microbiol. 2013 Jul;11(7):497-504
pubmed: 23748339
FEMS Microbiol Rev. 2018 Mar 1;42(2):146-164
pubmed: 29325042
Mucosal Immunol. 2017 Jan;10(1):91-103
pubmed: 27143302
Proc Natl Acad Sci U S A. 2012 Jan 17;109(3):781-6
pubmed: 22219371
J Biol Chem. 2007 Apr 13;282(15):11291-9
pubmed: 17287210
Biochim Biophys Acta. 2013 Aug;1834(8):1510-9
pubmed: 23665536
Expert Rev Gastroenterol Hepatol. 2019 Oct;13(10):963-976
pubmed: 31603356
Am J Gastroenterol. 2010 Nov;105(11):2420-8
pubmed: 20648002
Nature. 2015 Jan 8;517(7533):165-169
pubmed: 25567280
J Biol Chem. 2009 Sep 11;284(37):24673-7
pubmed: 19553672
Chem Biol Drug Des. 2008 Dec;72(6):455-82
pubmed: 19090915
mBio. 2015 Nov 10;6(6):e01282-15
pubmed: 26556271
PLoS One. 2012;7(1):e30287
pubmed: 22299034
Int J Syst Evol Microbiol. 2004 Sep;54(Pt 5):1469-1476
pubmed: 15388697
Mol Microbiol. 2014 Sep;93(5):1010-25
pubmed: 25041429
Cell Host Microbe. 2018 Jun 13;23(6):705-715
pubmed: 29902436
Nature. 2016 Jul 06;535(7610):56-64
pubmed: 27383980
PLoS One. 2016 Oct 17;11(10):e0164846
pubmed: 27749924
Proc Natl Acad Sci U S A. 2012 May 8;109(19):7298-303
pubmed: 22532667
Cell Host Microbe. 2011 May 19;9(5):390-403
pubmed: 21575910