GLOBAL AND TARGETED PROFILING OF GTP-BINDING PROTEINS IN BIOLOGICAL SAMPLES BY MASS SPECTROMETRY.
GTP-binding proteins
activity-based protein profiling
posttranslational modifications
shotgun proteomics
small GTPases
targeted proteomics
Journal
Mass spectrometry reviews
ISSN: 1098-2787
Titre abrégé: Mass Spectrom Rev
Pays: United States
ID NLM: 8219702
Informations de publication
Date de publication:
05 2021
05 2021
Historique:
revised:
04
05
2020
received:
25
02
2020
accepted:
15
05
2020
pubmed:
11
6
2020
medline:
23
11
2021
entrez:
11
6
2020
Statut:
ppublish
Résumé
GTP-binding proteins are among the most important enzyme families that are involved in a plethora of biological processes. However, owing to the enormous diversity of the nucleotide-binding protein family, comprehensive analyses of the expression level, structure, activity, and regulatory mechanisms of GTP-binding proteins remain challenging with the use of conventional approaches. The many advances in mass spectrometry (MS) instrumentation and data acquisition methods, together with a variety of enrichment approaches in sample preparation, render MS a powerful tool for the comprehensive characterizations of the activities and expression levels of various GTP-binding proteins. We review herein the recent developments in the application of MS-based techniques, together with general and widely used affinity enrichment approaches, for the proteome-wide and targeted capture, identification, and quantification of GTP-binding proteins. The working principles, advantages, and limitations of various strategies for profiling the expression level, activity, posttranslational modifications, and interactome of GTP-binding proteins are discussed. It can be envisaged that future applications of MS-based proteomics will lead to a better understanding about the roles of GTP-binding proteins in different biological processes and human diseases. © 2020 John Wiley & Sons Ltd. Mass Spec Rev.
Identifiants
pubmed: 32519381
doi: 10.1002/mas.21637
pmc: PMC7725852
mid: NIHMS1605985
doi:
Substances chimiques
Affinity Labels
0
Guanine
5Z93L87A1R
GTP-Binding Proteins
EC 3.6.1.-
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
215-235Subventions
Organisme : NCI NIH HHS
ID : R01 CA210072
Pays : United States
Organisme : NIEHS NIH HHS
ID : T32 ES018827
Pays : United States
Informations de copyright
© 2020 John Wiley & Sons Ltd.
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