Cerebrospinal Fluid Findings of 36 Adult Patients with Autism Spectrum Disorder.
Asperger syndrome
GAD65
adults
antibodies
autism spectrum disorder
blood–brain barrier
cerebrospinal fluid
Journal
Brain sciences
ISSN: 2076-3425
Titre abrégé: Brain Sci
Pays: Switzerland
ID NLM: 101598646
Informations de publication
Date de publication:
08 Jun 2020
08 Jun 2020
Historique:
received:
12
04
2020
revised:
01
06
2020
accepted:
01
06
2020
entrez:
12
6
2020
pubmed:
12
6
2020
medline:
12
6
2020
Statut:
epublish
Résumé
Autism spectrum disorder (ASD) is a common neurodevelopmental disorder characterized by difficulties with social interaction, repetitive behavior, and additional features, such as special interests. Its precise etiology is unclear. Recently, immunological mechanisms, such as maternal autoantibodies/infections, have increasingly been the subject of discussion. Cerebrospinal fluid (CSF) investigations play a decisive role in the detection of immunological processes in the brain. This study therefore retrospectively analyzed the CSF findings of adult patients with ASD. CSF basic measures (white blood cell count, total protein, albumin quotient, immunoglobulin G (IgG) index, and oligoclonal bands) and various antineuronal antibody findings of 36 adult patients with ASD, who had received lumbar puncture, were compared with an earlier described mentally healthy control group of 39 patients with idiopathic intracranial hypertension. CSF protein concentrations and albumin quotients of patients with ASD were significantly higher as compared to controls (age corrected:
Identifiants
pubmed: 32521749
pii: brainsci10060355
doi: 10.3390/brainsci10060355
pmc: PMC7349103
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Deutsche Forschungsgemeinschaft
ID : unknown
Organisme : Albert-Ludwigs-Universität Freiburg
ID : unknown
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