Notch-Mediated Generation of Monocyte-Derived Langerhans Cells: Phenotype and Function.
Journal
The Journal of investigative dermatology
ISSN: 1523-1747
Titre abrégé: J Invest Dermatol
Pays: United States
ID NLM: 0426720
Informations de publication
Date de publication:
01 2021
01 2021
Historique:
received:
27
11
2019
revised:
01
05
2020
accepted:
04
05
2020
pubmed:
12
6
2020
medline:
7
9
2021
entrez:
12
6
2020
Statut:
ppublish
Résumé
Langerhans cells (LCs) in the skin are a first line of defense against pathogens but also play an essential role in skin homeostasis. Their exclusive expression of the C-type lectin receptor Langerin makes them prominent candidates for immunotherapy. For vaccine testing, an easily accessible cell platform would be desirable as an alternative to the time-consuming purification of LCs from human skin. Here, we present such a model and demonstrate that monocytes in the presence of GM-CSF, TGF-β1, and the Notch ligand DLL4 differentiate within 3 days into CD1a
Identifiants
pubmed: 32522485
pii: S0022-202X(20)31663-8
doi: 10.1016/j.jid.2020.05.098
pmc: PMC7758629
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
84-94.e6Subventions
Organisme : Austrian Science Fund FWF
ID : P 29919
Pays : Austria
Informations de copyright
Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.