Coping with hypoxemia: Could erythropoietin (EPO) be an adjuvant treatment of COVID-19?
Acute respiratory distress
High-altitude hypoxia
Hypoxic acclimatization
Respiratory system
Silent hypoxemia
Journal
Respiratory physiology & neurobiology
ISSN: 1878-1519
Titre abrégé: Respir Physiol Neurobiol
Pays: Netherlands
ID NLM: 101140022
Informations de publication
Date de publication:
08 2020
08 2020
Historique:
received:
22
05
2020
revised:
29
05
2020
accepted:
30
05
2020
pubmed:
12
6
2020
medline:
5
8
2020
entrez:
12
6
2020
Statut:
ppublish
Résumé
A very recent epidemiological study provides preliminary evidence that living in habitats located at 2500 m above sea level (masl) might protect from the development of severe respiratory symptoms following infection with the novel SARS-CoV-2 virus. This epidemiological finding raises the question of whether physiological mechanisms underlying the acclimatization to high altitude identifies therapeutic targets for the effective treatment of severe acute respiratory syndrome pivotal to the reduction of global mortality during the COVID-19 pandemic. This article compares the symptoms of acute mountain sickness (AMS) with those of SARS-CoV-2 infection and explores overlapping patho-physiological mechanisms of the respiratory system including impaired oxygen transport, pulmonary gas exchange and brainstem circuits controlling respiration. In this context, we also discuss the potential impact of SARS-CoV-2 infection on oxygen sensing in the carotid body. Finally, since erythropoietin (EPO) is an effective prophylactic treatment for AMS, this article reviews the potential benefits of implementing FDA-approved erythropoietin-based (EPO) drug therapies to counteract a variety of acute respiratory and non-respiratory (e.g. excessive inflammation of vascular beds) symptoms of SARS-CoV-2 infection.
Identifiants
pubmed: 32522574
pii: S1569-9048(20)30134-8
doi: 10.1016/j.resp.2020.103476
pmc: PMC7275159
pii:
doi:
Substances chimiques
Erythropoietin
11096-26-7
Types de publication
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
103476Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.
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