The Inhibitory Effect of Gut Microbiota and Its Metabolites on Colorectal Cancer.


Journal

Journal of microbiology and biotechnology
ISSN: 1738-8872
Titre abrégé: J Microbiol Biotechnol
Pays: Korea (South)
ID NLM: 9431852

Informations de publication

Date de publication:
28 Nov 2020
Historique:
received: 17 02 2020
revised: 24 05 2020
accepted: 31 05 2020
pubmed: 12 6 2020
medline: 7 7 2021
entrez: 12 6 2020
Statut: ppublish

Résumé

Colorectal cancer (CRC) is regarded as one of the most common and deadly forms of cancer. Gut microbiota is vital to retain and promote several functions of intestinal. Although previous researches have shown that some gut microbiota have the abilities to inhibit tumorigenesis and prevent cancer from progressing, they have not yet clearly identified associative mechanisms. This review not only concentrates on the antitumor effects of metabolites produced by gut microbiota, for example, SCFA, ferrichrome, urolithins, equol and conjugated linoleic acids, but also the molecules which constituted the bacterial cell wall have the antitumor effect in the host, including lipopolysaccharide, lipoteichoic acid, β-glucans and peptidoglycan. The aim of our review is to develop a possible therapeutic method, which use the products of gut microbiota metabolism or gut microbiota constituents to help treat or prevent colorectal cancer.

Identifiants

pubmed: 32522960
pii: jmb.2002.02032
doi: 10.4014/jmb.2002.02032
pmc: PMC9728159
doi:

Substances chimiques

Antineoplastic Agents 0
Linoleic Acids 0
Ferrichrome 15630-64-5
Equol 531-95-3

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

1607-1613

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Auteurs

Chao Chen (C)

Department of Colorectal Surgery, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310000, Zhejiang Province, P.R. China.

Huajun Li (H)

Department of Microecology, College of Basic Medical Sciences, Dalian Medical University, Dalian, Liaoning 116044, P.R. China.

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Classifications MeSH