Eosinophil function in adipose tissue is regulated by Krüppel-like factor 3 (KLF3).
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
10 06 2020
10 06 2020
Historique:
received:
07
11
2018
accepted:
20
05
2020
entrez:
12
6
2020
pubmed:
12
6
2020
medline:
25
8
2020
Statut:
epublish
Résumé
The conversion of white adipocytes to thermogenic beige adipocytes represents a potential mechanism to treat obesity and related metabolic disorders. However, the mechanisms involved in converting white to beige adipose tissue remain incompletely understood. Here we show profound beiging in a genetic mouse model lacking the transcriptional repressor Krüppel-like factor 3 (KLF3). Bone marrow transplants from these animals confer the beige phenotype on wild type recipients. Analysis of the cellular and molecular changes reveal an accumulation of eosinophils in adipose tissue. We examine the transcriptomic profile of adipose-resident eosinophils and posit that KLF3 regulates adipose tissue function via transcriptional control of secreted molecules linked to beiging. Furthermore, we provide evidence that eosinophils may directly act on adipocytes to drive beiging and highlight the critical role of these little-understood immune cells in thermogenesis.
Identifiants
pubmed: 32523103
doi: 10.1038/s41467-020-16758-9
pii: 10.1038/s41467-020-16758-9
pmc: PMC7286919
doi:
Substances chimiques
Klf3 protein, mouse
0
Kruppel-Like Transcription Factors
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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